Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions

Title:Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions

Volume: 21

Author(s): Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan and Zhi-Wei Chen*

Affiliation:

• College of Pharmaceutical Sciences, Zhejiang University of Technology. Hangzhou, Chao Wang Road 18th, 310014, China

Keywords: Cyclization;, radical cascade reaction, Electrooxidation, Coumarin, Quinolin-2-one

Abstract: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.

Cite this article as:

Zhang Shuo, Tang Wei, Zhou Kai, Huan Xiao-Xiao and Chen Zhi-Wei*, Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions, Mini-Reviews in Organic Chemistry 2024; 21 () . https://dx.doi.org/10.2174/0118756298278048231205053801