References
Guo H, Li Y, Hou W, Cai Y. Brain glycogen: An angel or a devil for ischemic stroke? Neurosci Bull 2023, 39: 690–694.
Xu J, Zhang W, Dong J, Cao L, Huang Z. A new potential strategy for treatment of ischemic stroke: Targeting TRPM2-NMDAR association. Neurosci Bull 2023, 39: 703–706.
Liddelow SA, Sofroniew MV. Astrocytes usurp neurons as a disease focus. Nat Neurosci 2019, 22: 512–513.
Boghdadi AG, Spurrier J, Teo L, Li M, Skarica M, Cao B. NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in Primates. Nat Commun 2021, 12: 6906.
Wang T, Xiong JQ, Ren XB, Sun W. The role of Nogo-a in neuroregeneration: A review. Brain Res Bull 2012, 87: 499–503.
Krienen FM, Goldman M, Zhang Q, Del Rosario RCH, Florio M, Machold R, et al. Innovations present in the primate interneuron repertoire. Nature 2020, 586: 262–269.
Xie YX, Zhang M, Zhang CR, Chen F. Relationship between NogoA/NgR1/RhoA signaling pathway and the apoptosis of cerebral neurons after cerebral infarction in rats. Eur Rev Med Pharmacol Sci 2020, 24: 295–303.
Pernet V, Schwab ME. The role of Nogo-a in axonal plasticity, regrowth and repair. Cell Tissue Res 2012, 349: 97–104.
Liu Y, Ma C, Li H, Shen H, Li X, Fu XA, et al. Nogo-A/pir-B/TrkB signaling pathway activation inhibits neuronal survival and axonal regeneration after experimental intracerebral hemorrhage in rats. J Mol Neurosci 2019, 69: 360–370.
Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, et al. Nogo-a is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000, 403: 434–439.
GrandPré T, Nakamura F, Vartanian T, Strittmatter SM. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403: 439–444.
Teo L, Boghdadi AG, de Souza M, Bourne JA. Reduced post-stroke glial scarring in the infant primate brain reflects age-related differences in the regulation of astrogliosis. Neurobiol Dis 2018, 111: 1–11.
Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, et al. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature 2013, 494: 90–94.
Otero-Ortega L, Frutos MCGD, Laso-García F, Sánchez-Gonzalo A, Martínez-Arroyo A, Díez-Tejedor E, et al. NogoA neutralization promotes axonal restoration after white matter injury in subcortical stroke. Sci Rep 2017, 7: 9431.
Wang J, Ni G, Liu Y, Han Y, Jia L, Wang Y. Tanshinone IIA promotes axonal regeneration in rats with focal cerebral ischemia through the inhibition of nogo-A/NgR1/RhoA/ROCKII/MLC signaling. Drug Des Devel Ther 2020, 14: 2775–2787.
Huang S, Huang D, Zhao J, Chen L. Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling. Exp Ther Med 2017, 14: 905–912.
Mao R, Zong N, Hu Y, Chen Y, Xu Y. Neuronal death mechanisms and therapeutic strategy in ischemic stroke. Neurosci Bull 2022, 38: 1229–1247.
Elliott Donaghue I, Tator CH, Shoichet MS. Local delivery of neurotrophin-3 and anti-NogoA promotes repair after spinal cord injury. Tissue Eng Part A 2016, 22: 733–741.
Ueno R, Takase H, Suenaga J, Kishimoto M, Kurihara Y, Takei K, et al. Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy. Exp Neurol 2020, 323: 113068.
Acknowledgments
This Insight article was supported by the Science and Technology Developmental Plan of Henan Province, China (232102520025), and The National Foreign Expert Program of China (QN2022026001L).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The author declares that there are no conflicts of interest.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Khan, S., Nasir, A. Can NogoA Be a Suitable Target to Treat Ischemic Stroke?. Neurosci. Bull. 40, 557–560 (2024). https://doi.org/10.1007/s12264-023-01164-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12264-023-01164-0