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Preparation and Physicochemical Characterizations of Niosomal Benzoyl Peroxide and Clindamycin Phosphate Formulation for Acne Vulgaris

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Abstract

Purpose

This study aimed to prepare and characterize a topical niosomal formulation of benzoyl peroxide (BP) and clindamycin phosphate (CMP) for the treatment of acne vulgaris.

Methods

Different combinations of Polyoxyethylene Alkyl Ethers (Brij), sorbitan esters (Span), and their ethoxylated derivatives (Tween), and cholesterol were used to produce the niosomes. Encapsulation, release, chemical and physical stabilities of the prepared formulations were studied.

Results

The studied niosomes exhibited high physical stability, as evidenced by unchanged size distribution over a six-month storage period. Formulations composed of Brij-52 combined with 50 mol% of cholesterol showed the highest encapsulation efficiency for both CMP (81.5 ± 7.4%) and BP (95.6 ± 3.5%). The release rate of CMP was found to be greater than BP.

Conclusions

It was concluded that niosomes could serve as stable carriers for topical drug delivery of CMP and BP, specifically in the treatment of acne vulgaris.

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Authors and Affiliations

  1. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, 08854, USA

    Maryam Rezaeizadeh

  2. John and Willie Leone Family Department of Energy and Mineral Engineering, College of Earth and Mineral Science, Pennsylvania State University, University Park, State College, Pennsylvania, 16802, USA

    Amir Eskanlou

  3. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, Iran

    Abbas Pardakhty, Mostafa Pournamdari & Mohammad Daneshpajooh

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  1. Maryam Rezaeizadeh
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Correspondence to Maryam Rezaeizadeh.

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Rezaeizadeh, M., Eskanlou, A., Pardakhty, A. et al. Preparation and Physicochemical Characterizations of Niosomal Benzoyl Peroxide and Clindamycin Phosphate Formulation for Acne Vulgaris. J Pharm Innov 19, 1 (2024). https://doi.org/10.1007/s12247-024-09807-z

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