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Effect of Patient Characteristics, Including Cardiothoracic Ratio, on Vessel Enhancement in Coronary Computed Tomography Angiography

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Abstract

This retrospective study aimed to evaluate the effects of various patient characteristics, including cardiothoracic ratio (CTR), on vessel enhancement in coronary computed tomography (CT) angiography (CCTA). We screened the 306 patients who underwent CCTA with 80-detector row CT for clinical assessment due to suspected or confirmed coronary artery disease. The change in iodine dose per contrast enhancement (IDCE) (mgI/HU) was calculated as the product of 300 mgI multiplied by total body weight (TBW), divided by the change in Hounsfield unit (HU) obtained by subtracting the HU value. CTR was measured on CT images in scout view. Subsequently, we conducted linear regression analyses among age, sex, body size, CTR, heart rate, scan length, and scan start on IDCE. To evaluate the effects of age, sex, BSA, heart rate, scan length, scan start, and CTR on the IDCE, we used multivariate regression analysis. A significant positive correlation was observed between coronary artery IDCE and patient age (r2 = 0.07, p < 0.01). Linear regression analysis revealed inverse correlations between coronary artery IDCE and height (r2 =  − 0.30), total body weight (r2 =  − 0.53), body mass index (r2 =  − 0.23), body surface area (BSA; r2 =  − 0.56), lean body weight (r2 =  − 0.50), scan length (r2 =  − 0.01), and CTR (r2 =  − 0.02). There was no significant correlation between coronary artery IDCE and heart rate (r2 = 0.00, p = 0.74) or scan start (r2 =  − 0.01, p = 0.10). Standardized regression coefficients showed that the effect of BSA (− 0.71) was greater than that of other variables (CTR − 0.14, scan start − 0.10). The results of this study showed that patient BSA, CTR, and start scan significantly affect the IDCE of the coronary artery on CCTA images.

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Data Availability

Clinical data use cannot be disclosed due to ethical concerns.

Code Availability

Not applicable.

Abbreviations

CCTA:

Coronary CT angiography

CE:

Contrast enhancement

CT:

Computed tomography

CTR:

Cardiothoracic ratio

IDCE:

Iodine dose per contrast enhancement

BSA:

Body surface area

HU:

Hounsfield units

LBW:

Lean body weight

TBW:

Total body weight

BMI:

Body mass index

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Authors and Affiliations

  1. Department of Radiological Technology, Kawasaki Medical School Hospital, 577, Matsushima, Kurashiki City, Okayama, 701-0192, Japan

    Tetsuya Ishikawa, Hiroyuki Ikenaga, Hiroyasu Sanai, Ryo Moriwake, Daiki Yao & Koji Yoshida

  2. Department of Radiological Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288, Matsushima, Kurashiki, Okayama, 701-0193, Japan

    Takanori Masuda, Atsushi Ono & Junichi Hiratsuka

  3. Department of Radiology, Kawasaki Medical School, 577, Matsushima, Kurashiki City, Okayama, 701-0192, Japan

    Tsutomu Tamada

Authors
  1. Tetsuya Ishikawa
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  2. Takanori Masuda
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  3. Hiroyuki Ikenaga
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  4. Hiroyasu Sanai
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Contributions

TM: conceived and designed the analysis, collected the data, contributed data or analysis tools, performed the analysis, wrote the paper.

TI: conceived and designed the analysis, collected the data, contributed data or analysis tools, wrote the paper.

HI: conceived and designed the analysis, collected the data.

HS: conceived and designed the analysis, collected the data.

RM: conceived and designed the analysis, collected the data.

DY: conceived and designed the analysis, collected the data.

KY: conceived and designed the analysis, collected the data.

AO: conceived and designed the analysis, collected the data.

JH: conceived and designed the analysis, collected the data.

TT: conceived and designed the analysis, collected the data.

Corresponding author

Correspondence to Takanori Masuda.

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Ethics Approval

This retrospective study was approved by the institutional review board of the Kawasaki Medical School Hospital (No. 5606–00), with the requirement for informed patient consent being waived.

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Not applicable.

Competing Interests

The authors declare no competing interests.

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Ishikawa, T., Masuda, T., Ikenaga, H. et al. Effect of Patient Characteristics, Including Cardiothoracic Ratio, on Vessel Enhancement in Coronary Computed Tomography Angiography. SN Compr. Clin. Med. 6, 9 (2024). https://doi.org/10.1007/s42399-024-01639-9

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