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Semin Respir Crit Care Med 2024; 45(02): 225-236
DOI: 10.1055/s-0043-1778139
Review Article

Treatment Failure and Clinical Stability in Severe Community-Acquired Pneumonia

Raúl Méndez
1   Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain
2   Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain
3   Department of Medicine, University of Valencia, Valencia, Spain
4   Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
,
Paula González-Jiménez
1   Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain
2   Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain
3   Department of Medicine, University of Valencia, Valencia, Spain
,
Noé Mengot
1   Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain
2   Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain
,
Rosario Menéndez
1   Pneumology Department, La Fe University and Polytechnic Hospital, Valencia, Spain
2   Respiratory Infections, Health Research Institute La Fe (IISLAFE), Valencia, Spain
3   Department of Medicine, University of Valencia, Valencia, Spain
4   Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
› Author Affiliations Funding R.M. is the recipient of a Juan Rodés grant, supported by the Instituto de Salud Carlos III (ISCIII [JR21/00051]). P.G.-J. is the recipient of a postresident research grant supported by the Health Research Institute La Fe (2019-053-1).
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Abstract

Treatment failure and clinical stability are important outcomes in community-acquired pneumonia (CAP). It is essential to know the causes and risk factors for treatment failure and delay in reaching clinical stability in CAP. The study of both as well as the associated underlying mechanisms and host response are key to improving outcomes in pneumonia.

Keywords

CAP - inflammatory-immune response - microbiologic treatment


Publication History

Article published online:
15 January 2024

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