Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria
Hitoshi Kamauchi , Mayu Tanaka, Mitsuaki Suzuki, Miho Furukawa, Atsushi Ikeda, Chihiro Sasho, Yuka Kiba, Masashi Kitamura, Koichi Takao, Yoshiaki Sugita
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Keywords: aromatic polyketide, fungal metabolite, Curvularia species, cyclopentabenzopyran-4-one, acetate-malonate pathway
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2024 Volume 72 Issue 1 Pages 98-101

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Abstract

A novel tricyclic polyketide, curvulanone (1), was isolated from the marine-derived fungus Curvularia aeria. The structure of 1 was determined by NMR and single-crystal X-ray crystallography. 1 had a cyclopentabenzopyranone with 3-acetic acid structure that is rarely found in natural compounds. Monoamine oxidase and sirtuin 1 inhibitory test was exhibited and 1 showed their inhibitory activity.

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© 2024 The Pharmaceutical Society of Japan
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