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The green synthesis of biocompatible nanocomposites and its application for the on-target delivery of the anticancer drugs

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Abstract

The main obstacle in the treatment of cancer is the non-selectivity of chemotherapy between infected and healthy cells. The purpose of the study was to develop on target drug delivery system for the Rhabdomyosarcoma cells (RD cells). The co-precipitation method was employed for the synthesis of Cobalt ferrite nanoparticles (CFNPs) and Polyvinyl alcohol (PVA) coated CFNPs. The cytotoxicity of these nanomaterials was tested against the RD cell lines. The photosensitizer was used as an initiator of photodamage on RD cell lines. The cellular uptake of 5-Aminolaevulinic Acid (ALA) was maximum after 5 h of in vitro incubation. The PVA/CFNPs loaded with ALA (250 nM) and a laser dose of 55 J/cm2, showed 52% cell viability, while PVA/CFNPs loaded with both ALA and Dacarbazine (DTIC) followed by a laser dose showed 35% cell viability. This confirms the plausibility of DTIC-loaded CFNPs as a drug delivery agent for cancer drugs.

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Authors and Affiliations

  1. Department of Chemistry, Kohat University of Science and Technology, Kohat, 26000, Pakistan

    Muhammad Zakir, Muhammad Iqbal Khan & Murad Ali Khan

  2. Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, 45650, Pakistan

    Ahmat Khurshid & Muhammad Asim Rasheed

  3. Department of Zoology, Kohat University of Science and Technology, Kohat, 26000, Pakistan

    Asma Khattak & Noor ul Akbar

  4. Department of Physics, Islamia College University Peshawar, Peshawar, Pakistan

    Niqab Khan

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  1. Muhammad Zakir
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Zakir, M., Khurshid, A., Rasheed, M.A. et al. The green synthesis of biocompatible nanocomposites and its application for the on-target delivery of the anticancer drugs. Journal of Materials Research 39, 325–341 (2024). https://doi.org/10.1557/s43578-023-01208-1

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