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Could an increased risk of obstructive sleep apnoea be one of the determinants associated with disability in individuals with cardiovascular and cerebrovascular diseases?

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

To investigate a possible association between the risk of obstructive sleep apnoea (OSA) and disability in individuals with cardiovascular or cerebrovascular diseases.

Methods

Cross-sectional study was conducted with 373 individuals (313 with cardiovascular or cerebrovascular diseases and 60 healthy). Disability was assessed by the 12-item World Health Organization Disability Assessment Schedule (WHODAS), and the risk of OSA was assessed by STOP-BANG. Anxiety and depression symptoms, daytime sleepiness, and cognition were assessed by the Hospital Anxiety and Depression Scale (HADS), Epworth Sleepiness Scale (ESS), and Mini Mental State Examination (MMSE).

Results

Greater disability was found in individuals with intermediate or high risk of OSA, considering healthy individuals (p=0.03), or individuals diagnosed with arrhythmia (p<0.01) or coronary artery disease (p=0.04). A high risk of OSA and higher WHODAS scores was significant among women as well as between OSA risk categories (p<0.01). Cognitive deficit and level of education also showed differences between OSA risk categories. Age, depression, and sleepiness were also associated with the subjects’ disability (p<0.01). Gamma regression model showed higher WHODAS scores in female, in those with intermediate and high risk of OSA, and in those with depressive symptoms and cognitive deficit. Age also showed a correlation with higher WHODAS scores. The presence of all investigated cardio and cerebrovascular diseases showed an increase in the WHODAS score, implying a greater disability compared to healthy individuals.

Conclusion

Moderate and high risk of OSA is associated with disability, as well as gender, age, depressive symptoms, cognitive deficit, and cardiovascular diseases.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors thank the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES), and the Brazilian National Council for Scientific and Technological Development (CNPq – Conselho Nacional de Desenvolvimento Científico e Tecnológico).

Funding

This study was financed in part by the National Council for Scientific and Technological Development (CNPq – Conselho Nacional de Desenvolvimento Científico e Tecnológico), approved in grant 409321/2021-4.

Author information

Authors and Affiliations

  1. Graduate Program in Cardiovascular Sciences, Federal University of Ceara, Fortaleza, Ceara, Brazil

    Eriádina Alves de Lima & Camila Ferreira Leite

  2. Master Program in Physiotherapy and Functioning, Federal University of Ceara, Fortaleza, Ceara, Brazil

    Shamyr Sulyvan Castro & Camila Ferreira Leite

  3. Clinical Research Unit of Hospital Universitário Walter Cantidio, Federal University of Ceara/EBSERH, Fortaleza, Ceara, Brazil

    Antonio Brazil Viana-Júnior

  4. Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil

    Manoel Alves Sobreira-Neto

Authors
  1. Eriádina Alves de Lima
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  2. Shamyr Sulyvan Castro
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  3. Antonio Brazil Viana-Júnior
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  4. Manoel Alves Sobreira-Neto
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  5. Camila Ferreira Leite
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Contributions

EAL: preparation and planning of work, data acquisition, and drafting of manuscript. SSC; MAS-N: critical revision of the work for important intellectual content. ABVJ: methodological review and statistical analysis. CFL: draft preparation, revision, and study conceptualization.

Corresponding author

Correspondence to Camila Ferreira Leite.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Resolution 466/12 of the Brazilian National Health Council, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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de Lima, E.A., Castro, S.S., Viana-Júnior, A.B. et al. Could an increased risk of obstructive sleep apnoea be one of the determinants associated with disability in individuals with cardiovascular and cerebrovascular diseases?. Sleep Breath (2024). https://doi.org/10.1007/s11325-024-02989-3

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  • DOI: https://doi.org/10.1007/s11325-024-02989-3

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