Microbiome diversity has been associated with improved outcomes after allogeneic stem-cell transplantation in patients with hematological cancers. Multimodal analysis of intestinal microbiome and metabolome data helped identify immunomodulatory microbial metabolites that were predictive of survival, transplant-related mortality and cancer relapse. These metabolites were products of short-chain-fatty-acid-synthesis pathways, and their associated genes were expressed by both bacterial species and bacteriophages.
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References
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This is a summary of: Thiele Orberg, E. et al. Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nat. Cancer https://doi.org/10.1038/s43018-023-00669-x (2024).
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Immunomodulatory microbial metabolites as potential predictors of stem-cell transplantation outcomes. Nat Cancer 5, 14–15 (2024). https://doi.org/10.1038/s43018-023-00670-4
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DOI: https://doi.org/10.1038/s43018-023-00670-4
