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Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018

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Abstract

Hypertension and osteoporosis are common geriatric diseases, sharing similar risk factors. This study aims to investigate this association and explore relatively mixed variables. Our study included 12,787 eligible participants from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Included participants had valid data on hypertension and osteoporosis, without tumors, liver diseases, gout or thyroid diseases. We explored the association between hypertension and osteoporosis by logistic regression and examined blood pressure and BMD/BMC by linear and non-linear regression. Moreover, we used machine learning models to predict the importance of various factors in the occurrence of osteoporosis and evaluated causality by mendelian randomization. Our study found that osteoporosis is significantly associated with hypertension [OR 2.072 (95% CI 2.067–2.077), p < 0.001]. After adjusting for co-variances, the association remained significant [OR 1.223 (95% CI 1.220–1.227), p < 0.001]. Our study showed that osteoporosis is positively associated with hypertension in the US population. A variety of factors influence this relationship. Specific regulatory mechanisms and confounding factors need to be further investigated.

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Data Availability

The data that support the findings of this study are openly available in NHANES (NHANES Questionnaires, Datasets, and Related Documentation (cdc.gov)).

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Funding

This research was funded by the Special Support Project for High-level Talents of Shaanxi Province (2020), the Shaanxi Provincial Key Research and Development Project(2020GXLH-Y-027), the Scientific Research Project of Xi’an Health Commission(2020qn16).

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Author notes

  1. Shixuan Liu, Shaobo Wu and Xueyuan Bao have contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, 710054, China

    Shixuan Liu, Shaobo Wu, Jiajia Ji, Yuxing Ye, Jinniu Guo, Jiateng Liu, Xi Wang, Dingjun Hao & Dageng Huang

  2. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China

    Xueyuan Bao

  3. Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Yan Zhang

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  1. Shixuan Liu
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Contributions

SL, SW, and XB were major contributors in methodology, investigation, and writing. JJ, YY, JG, JL, and XW were responsible for the formal analysis and data curation. DH, DH, and YZ were responsible for the conceptualization and production of this study. All authors wrote the original draft and approved the final manuscript.

Corresponding authors

Correspondence to Yan Zhang, Dingjun Hao or Dageng Huang.

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Disclosure

Shixuan Liu, Shaobo Wu, Xueyuan Bao, Jiajia Ji, Yuxing Ye, Jinniu Guo, Jiateng Liu, Xi Wang, Yan Zhang, Dingjun Hao, Dageng Huang declare that they have no conflicts of interest.

Informed Consent

The NHANES data were reviewed by an ethics committee (https://www.cdc.gov/nchs/nhanes/irba98.htm). For this type of study formal consent is not required.

Human and Animal Rights

All participants of the original studies included in the NHANES database have provided the informed consent.

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Liu, S., Wu, S., Bao, X. et al. Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018. Calcif Tissue Int 114, 276–285 (2024). https://doi.org/10.1007/s00223-023-01176-y

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