Enhanced Physical Stability of L-Ascorbic Acid in an Ionic Liquid

Takeshi Oshizaka; Issei Takeuchi; Katsuya Mukae; Kenji Mori; Kenji Sugibayashi

doi:10.1248/cpb.c23-00861

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Enhanced Physical Stability of L-Ascorbic Acid in an Ionic Liquid

Takeshi Oshizaka , Issei Takeuchi, Katsuya Mukae, Kenji Mori, Kenji Sugibayashi

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Keywords: L-ascorbic acid, stability, ionic liquid, pyridoxine

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2024 Volume 72 Issue 2 Pages 209-212

DOI https://doi.org/10.1248/cpb.c23-00861

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Abstract

Ionic liquid (IL) technology was used to enhance the stability of L-ascorbic acid (AA). Pyridoxine was selected as the counter cation for anionic AA in IL. After AA was dissolved in water at 40 °C, its ratio decreased to 3.2% after 7 d. In contrast, the IL formulation showed negligible degradation, with almost no loss of AA even after 28 d. These results suggest that the use of IL enhances the stability of AA.

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