Retrograde amnesia for the stress-induced impairment of extinction: time-dependent and not so forgotten
- Corresponding author: briggsj{at}susqu.edu
Abstract
We investigated whether retrograde amnesia for the stress-induced impairment of extinction retrieval shares similar characteristics with original acquisition memories. The first experiment demonstrated that cycloheximide administered shortly after a single restraint stress session alleviated the impairment of extinction retrieval but not when administered following a longer delay (i.e., the amnesia for stress is time-dependent). A second experiment showed that the retrograde amnesia for stress could be alleviated by a second brief exposure to the stressor. These results demonstrating that amnesia for stress shares characteristics similar to original memories are explained using a retrieval-based memory integration model of retrograde amnesia.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.053895.123.
- Received October 16, 2023.
- Accepted December 5, 2023.
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