An Overview of Diverse Biological Activities of Cinnoline Scaffold

Title:An Overview of Diverse Biological Activities of Cinnoline Scaffold

Volume: 21

Author(s): Mohammad Asif*, Mamdouh Allahyani, Abdulelah Aljuaid, Mazen M. Almehmadi, Ahad Alsaiari and Abdulaziz Alsharif

Affiliation:

• Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Keywords: Cinnoline, heterocyclic compounds, cyclization, biological activities.

Abstract: The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural subunit in various compounds with attractive medicinal and chemical properties. In this review, we focus on the biological activities of cinnoline analogs with various substitutions.

Cite this article as:

Asif Mohammad*, Allahyani Mamdouh, Aljuaid Abdulelah, M. Almehmadi Mazen, Alsaiari Ahad and Alsharif Abdulaziz, An Overview of Diverse Biological Activities of Cinnoline Scaffold, Mini-Reviews in Organic Chemistry 2024; 21 () . https://dx.doi.org/10.2174/0118756298265037231119063008