Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels

Title:Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels

Volume: 25

Author(s): Tat'yana Grigorievna Khonina*, Denis Sergeevich Tishin, Leonid Petrovich Larionov, Artur Vasilevich Osipenko, Maria Nikolaevna Dobrinskaya, Ekaterina Anatolievna Bogdanova, Maxim Sergeevich Karabanalov, Maria Alekseevna Bulatova, Elena Vladimirovna Shadrina and Oleg Nikolaevich Chupakhin

Affiliation:

• Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia
• Ural State Agrarian University, Yekaterinburg, Russia

Keywords: Silicon glycerolates, iron(III) monoglycerolate, sol-gel processing, biocompatible precursors, nanocomposite glycerohydrogel, hemostatic activity.

Abstract: Background: Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications.

Objective: Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method.

Methods: The composition and structural features of the hydrogel were studied using a complex of modern analytical techniques, including TEM, XRD, and AES. On the example of experimental animals hemostatic activity of the hydrogel was studied, as well as primary toxicological studies were carried out.

Results: The composition of dispersed phase and dispersion medium of silicon‒iron glycerolates hydrogel was determined. The structural features of hydrogel were revealed and its structure model was proposed. It was shown that silcon-iron glycerolates hydrogel is nontoxic, and exhibits pronounced hemostatic activity.

Conclusion: Silicon-iron glycerolates hydrogel is a potential hemostatic agent for topical application in medical and veterinary practice.

Cite this article as:

Khonina Grigorievna Tat'yana*, Tishin Sergeevich Denis, Larionov Petrovich Leonid, Osipenko Vasilevich Artur, Dobrinskaya Nikolaevna Maria, Bogdanova Anatolievna Ekaterina, Karabanalov Sergeevich Maxim, Bulatova Alekseevna Maria, Shadrina Vladimirovna Elena and Chupakhin Nikolaevich Oleg, Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels, Current Pharmaceutical Biotechnology 2024; 25 () . https://dx.doi.org/10.2174/0113892010269503231229100317