How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy triggered by phosphate starvation. This demonstrates the plasticity of the autophagy-initiating Atg1 complex.
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References
Zhang, H. Annu. Rev. Genet. 56, 17–39 (2022).
Suzuki, K. et al. Genes Cells 12, 209–218 (2007).
Fujioka, Y. et al. Nature 578, 301–305 (2020).
Matscheko, N. et al. PLoS Biol. 17, e3000377 (2019).
Farre, J. C. et al. Nat. Rev. Mol. Cell Biol. 17, 537–552 (2016).
Yao, W. et al. Autophagy 16, 2206–2218 (2020).
Gross, A. S. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01348-4 (2024).
Wang, Z. et al. Plant Physiol. 187, 2043–2055 (2021).
Motley, A. M. et al. EMBO J. 31, 2852–2868 (2012).
Hickey, K. L. et al. Nature 623, 167–174 (2023).
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Ma, X., Zhang, H. Compositional plasticity of the Atg1 complex. Nat Cell Biol 26, 313–315 (2024). https://doi.org/10.1038/s41556-023-01340-4
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DOI: https://doi.org/10.1038/s41556-023-01340-4
