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New voltammetric sensing technique for determination of paracetamol by l-phenylalanine based carbon paste electrode

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Abstract

In this work, the carbon paste electrode was electro-polymerized using l-phenylalanine in 0.2 M phosphate buffer solution of pH 8.0. This l-phenylalanine modified carbon paste electrode (PLPAMCPE) was used for the study of paracetamol (PCL). The modified electrode was characterized by cyclic voltammetry, differential pulse voltammetry (DPV), scanning electron microscopy, and electrochemical impedance spectroscopy. The PLPAMCPE showed an excellent current response towards the oxidation of PCL. During the pH study ranging from 5.0 to 8.0 pH, pH 6.0 showed high peak current hence considered as the optimum pH. The scan rate study showed that the reaction was adsorption-controlled reaction. Further study i.e., by varying concentration of PCL in the linear range of 1.2 µM to 12 µM, the current increases linearly. The limit of quantification of 18.2 μM and the limit of detection of 5.4 μM was obtained for the DPV method. The study also showed that the presence of different metal ions did not hinder the PCL analysis. The developed electrode showed good repeatability, stability, and reproducibility. Simultaneous study of PCL with dopamine shows good selectivity for PCL. This method is desirable due to its quickness, low cost, ease of handling, and its applicability to real sample.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Rajendra NG, Sudhanshu PS (2006) Electrochim Acta 51:3008

    Article  Google Scholar 

  2. Espinosa Bosch M, Ruiz Sanchez AJ, Sanchez Rojas F, Bosch Ojeda C (2006) J Pharm Biom Anal 42:291

    Article  CAS  Google Scholar 

  3. Narayana PV, Madhusudana Reddy T, Gopala P, Ramakrishna Naidu G (2014) Anal Method 6:9459

    Article  CAS  Google Scholar 

  4. Pattan-Siddappa G, Ganesh S, Sang-Youn K, Seok-Han L, Savas K, Rajae S (2021) Microchem J 167:106260

    Article  Google Scholar 

  5. Rohini MH, Suresh MT, Sharanappa TN, Jayant IG (2020) Chem Data Collect 30:100540

    Article  Google Scholar 

  6. Charithra MM, Manjunatha JG (2020) J Electrochem Sci Eng 10:29

    Article  CAS  Google Scholar 

  7. Roohollah TK, Gregory GW, Richard GC (2008) Anal Chim Acta 618:54

    Article  Google Scholar 

  8. Charithra MM, Manjunatha JG (2020) ChemistrySelect 5:9323

    Article  Google Scholar 

  9. Mangaiyarkarasi R, Premlatha S, Rajkumar K, Pratibha R, Umadevi S (2020) J Mol Liq 319:114255

    Article  CAS  Google Scholar 

  10. Premlatha S, Ramesh Bapu GNK (2018) J Electroanal Chem 822:33

    Article  CAS  Google Scholar 

  11. Tuğba TC (2020) Electroanalysis 33:1049

    Google Scholar 

  12. Waleed AE, Osama N, Ahmed IAS, Emad AE, Ziya AK, Fatma K (2021) Appl Surf Sci Adv 4:100065

    Article  Google Scholar 

  13. Morelli B (1989) J Pharm Biomed Anal 7:577

    Article  CAS  PubMed  Google Scholar 

  14. Hong-gang L, Hong Y, Zou-rong R, Bo J (2010) J Chrom B 878:682

    Article  Google Scholar 

  15. Mahendra KS, Saeed A, Dhirendra S, Ishwar CS (1985) Analyst 110:735

    Article  Google Scholar 

  16. Simin E, Mohammad HS, Lynn D (2021) Analyst 146:1326

    Article  Google Scholar 

  17. Usifoh CO, Adelusi SA, Adebambo RF (2002) Pak J Sci lnd Res 45:7

    CAS  Google Scholar 

  18. Al-Zoubi N, Koundourellis JE, Malamataris S (2002) J Pharm Biomed Anal 29:459

    Article  CAS  PubMed  Google Scholar 

  19. Eddleston MD, Bithell EG, Jones W (2010) J Pharm Sci 99:4072

    Article  CAS  PubMed  Google Scholar 

  20. Speed DJ, Dickson SJ, Cairns ER, Kim ND (2001) J Anal Toxicol 25:198

    Article  CAS  PubMed  Google Scholar 

  21. Heitmeier S, Blaschke G (1999) J Chrom B: Biomed Sci Appl 721:93

    Article  CAS  Google Scholar 

  22. Knochen M, Giglio J, Reis BF (2003) J Pharm Biomed Anal 33:191

    Article  CAS  PubMed  Google Scholar 

  23. Kutloano ES, Reitumetse N, Tebello N (2020) ChemistrySelect 5:9857

    Article  Google Scholar 

  24. Guo H, Li Y, Chen X, Nie L, He N (2005) Sensors 5:284

    Article  ADS  CAS  PubMed Central  Google Scholar 

  25. Rajendrachari S, Kumaraswamy BE (2020) Phys Chem Res 8:1

    Google Scholar 

  26. Bahmanzadeh S, Noroozifar M (2018) J Electroanal Chem 809:153

    Article  CAS  Google Scholar 

  27. Beitollahi H, Nejad FG, Dourandish Z, Aflatoonian MR (2023) Chemosphere 337:139369

    Article  CAS  PubMed  Google Scholar 

  28. Beitollahi H, Tajik S, Bartolomeo AD (2022) Micromachines 13:598

    Article  PubMed  PubMed Central  Google Scholar 

  29. Tajik S, Beitollahi H, Nejad FG, Safaei M, Zhang K, Le QV, Varma RS, Jang HW, Shokouhimehr M (2020) RSC Adv 10:21561

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  30. Beitollahi H, Safaei M, Tajik S (2019) Anal Bioanal Chem Res 6:81

    CAS  Google Scholar 

  31. Nejad HS, Nejad FG, Beitollahi H (2023) ADMET DMPK 11:361

    PubMed  PubMed Central  Google Scholar 

  32. Hareesha N, Manjunatha JG (2020) J Electroanal Chem 878:114533

    Article  CAS  Google Scholar 

  33. Manjunatha JG, Raril C, Hareesha N, Charithra MM, Pushpanjali PA, Tigari G, Ravishankar TK, Mallappaji SC, Gowda J (2020) Open Chem Eng J 14:90

    Article  CAS  Google Scholar 

  34. Shashanka R, Kumara Swamy BE (2020) SN Appl Sci 2:956

    Article  CAS  Google Scholar 

  35. Beigmoradi F, Beitollahi H (2022) J Electrochem Sci Eng 12:1205

    CAS  Google Scholar 

  36. Rajendrachari S, Basavegowda N, Adimule VM, Avar B, Somu P, Saravana Kumar RM, Baek KH (2022) Biosensors 12:1173

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Rajendrachari S, Arslanoglu H, Yaras A, Golabhanvi SM (2023) ACS Omega 8:46946

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Pattan SG, Kumara Swamy BE, Feyami OE, Ebenso EE (2018) J Electroanal Chem 813:193

    Article  Google Scholar 

  39. Rajendrachari S, Jayaprakash GK, Prakashaiah BG, Kumar M, Kumaraswamy BE (2022) Mater Res Innov 26:229

    Article  Google Scholar 

  40. Beitollahi H (2022) J Electrochem Sci Eng 12:1

    Article  Google Scholar 

  41. Manjunatha JG, Kanthappa B, Hareesha N, Raril C, Tighezza AM, Albaqami MD (2023). Chem Africa. https://doi.org/10.1007/s42250-023-00808-y

    Article  Google Scholar 

  42. Bhimaraya K, Manjunatha JG, Hareesha N, Tighezza AM, Albaqami MD, Sillanpää M (2023) Heliyon 9:11

    Article  Google Scholar 

  43. Amrutha BM, Manjunatha JG, Nagarajappa H, Tighezza AM, Albaqami MD, Sillanpää M (2022) Diagnostics 12:3113

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Manjunatha JG, Raril C, Prinith NS, Pushpanjali PA, Charithra MM, Girish T, Hareesha N, Edwin SD, Amrutha BM (2021) Fabrication, characterization and application of poly(acriflavine) modified carbon nanotube paste electrode for the electrochemical determination of catechol. In: Hussain CM, Kailasa SK (eds) Handbook of Nanomaterials for Sensing Applications. Elsevier, pp 105–117

    Chapter  Google Scholar 

  45. Laviron E (1972) Electroanal Chem Interf Electrochem 39:1

    Article  CAS  Google Scholar 

  46. Hareesha N, Manjunatha JG, Amrutha BM, Sreeharsha N, Basheeruddin Asdaq SM, Md Khalid A (2021) Colloids Surf A Physicochem Eng Asp 626:127042

    Article  CAS  Google Scholar 

  47. Ruiz CC, Bayona AH, Sanchez FG (1990) J Agric Food Chem 38:178

    Article  Google Scholar 

  48. Kumar SA, Tang CF, Chen SM (2008) Talanta 76:997

    Article  CAS  PubMed  Google Scholar 

  49. Manali MP, Nagaraj PS, Shweta JM, Deepti SN, Tirumal RC (2019) Mater Today: Proc 18:986

    Google Scholar 

  50. Mahesh A (2011) Pharm Methods 2:61

    Article  Google Scholar 

  51. Bouabi YE, Farahi A, Labjar N, El Hajjaji S, Bakasse M, El Mhammedi MA (2016) Mater Sci Eng C 58:70

    Article  Google Scholar 

  52. Doulache M, Saidat B, Trari M (2017) Russ J Electrochem 53:461

    Article  CAS  Google Scholar 

  53. Shang XG, Zhang H, Zheng J (2008) Anal Bioanal Chem 391:1049

    Article  Google Scholar 

  54. Amanda BL, Lívia MF, Carlos FR, Rodrigo MV, Leonardo M, Álvaro DC, Wallans TP (2014) J Braz Chem Soc 25:478

    Google Scholar 

  55. Jiang L, Shuqing G, Yaping D, Feng J, Zhen Z (2014) Nanoscale 6(1):207–214

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

J.G. Manjunatha gratefully acknowledges the financial support from VGST, Bangalore under Research project. No. K-FIST (L2)/GRD-1020/2021-22/430. Sameh M. Osman gratefully acknowledge the financial support from Researchers Supporting Project number (RSP2023R405), King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Chemistry, FMKMC College, Constituent College of Mangalore University, Madikeri, Karnataka, India

    Swathi Nayak, J. G. Manjunatha & K. P. Moulya

  2. Department of Chemistry, SDM College, University in Ujire, Ujire, Karnataka, India

    Swathi Nayak

  3. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia

    Sameh M. Osman

  4. Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano, 77, 38123, Trento, Italy

    N. Ataollahi

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  1. Swathi Nayak
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  2. J. G. Manjunatha
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  3. K. P. Moulya
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  4. Sameh M. Osman
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  5. N. Ataollahi
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Correspondence to J. G. Manjunatha.

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Nayak, S., Manjunatha, J.G., Moulya, K.P. et al. New voltammetric sensing technique for determination of paracetamol by l-phenylalanine based carbon paste electrode. Monatsh Chem 155, 155–163 (2024). https://doi.org/10.1007/s00706-024-03172-w

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  • DOI: https://doi.org/10.1007/s00706-024-03172-w

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