Despite a growing understanding of the immunostimulatory properties of mitochondrial DNA (mtDNA), little is known about how and why mtDNA escapes its mitochondrial confines. A study now describes an endosomal trafficking pathway that facilitates mtDNA egress and provides an additional mechanism of mtDNA release in vitro.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Riley, J. S. & Tait, S. W. EMBO Rep. 21, e49799 (2020).
Mahmoodpoor, A. et al. Gene 836, 146681–146681 (2022).
McArthur, K. et al. Science 359, eaao6047 (2018).
Kim, J. et al. Science 366, 1531–1536 (2019).
Rogers, C. et al. Nat. Commun. 10, 1689 (2019).
Newman, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01343-1 (2024).
West, A. P. et al. Nature 520, 553–557 (2015).
Zecchini, V. et al. Nature 615, 499–506 (2023).
White, M. J. et al. Cell 159, 1549–1562 (2014).
Moriyama, M., Koshiba, T. & Ichinohe, T. Nat. Commun. 10, 4624 (2019).
He, B. et al. Cell Rep. 41, 111774 (2022).
Sliter, D. A. et al. Nature 561, 258–262 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
McArthur, K., Kile, B.T. mtDNA caught in the act again. Nat Cell Biol 26, 177–178 (2024). https://doi.org/10.1038/s41556-024-01345-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-024-01345-7
