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Durable ventricular assist device in adult patients with single ventricle: a systematic literature review

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Abstract

The worldwide experience with mechanical circulatory support in adult patients with single ventricle and Fontan palliation is limited. We aimed to see the outcomes in such patients on durable left ventricular assist device. We systematically reviewed the English language literature found on PubMed and Google Scholar, searching the terms “Fontan,” “single ventricle,” “ventricular assist device,” “LVAD,” and “mechanical circulatory support,” and selected all individual cases with reported outcomes. We identified 4 patients on pulsatile left ventricular assist device, all of whom were successfully bridged to transplant, and 15 patients on continuous flow LVAD, age 25.9 ± 5.8, predominantly males. Mean time on LVAD support was 718.6 ± 616.5 days, and only 2 patients (13.3%) died. Durable left ventricular assist device support in adult patients with Fontan provides excellent results and should be used more frequently.

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Authors and Affiliations

  1. Krannert Institute of Cardiology, Indiana University School of Medicine, 1801 Senate Blvd Suite 2000, Indianapolis, IN, 46202, USA

    Kengo Z. Soghoyan & Maya Guglin

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  1. Kengo Z. Soghoyan
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  2. Maya Guglin
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Both authors independently reviewed the literature.  Kengo: first draft.  Guglin editing and adding sources.

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Correspondence to Maya Guglin.

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Soghoyan, K.Z., Guglin, M. Durable ventricular assist device in adult patients with single ventricle: a systematic literature review. Heart Fail Rev 29, 707–711 (2024). https://doi.org/10.1007/s10741-024-10391-0

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