Abstract
In this paper, the lamellar liquid crystals formed in S1570-Brij97/isopropyl myristate/PEG400 aqueous system were prepared at 37 °C. The effects of PEG400 and curcumin on the S1570-Brij97 lyotropic liquid crystal systems were studied by phase diagram, polarized optical microscopy, small angle X-ray scattering, and rheology. The prepared lamellar liquid crystals show stable structures at 37 °C. The encapsulation of curcumin improves the structural stability of the lamellar liquid crystals, which can be confirmed by their higher η γ=0.013 and σ y values, suggesting that the S1570-Brij97 lamellar liquid crystals are good carriers for curcumin. In addition, the prepared lamellar liquid crystals can effectively protect curcumin from decomposition, and curcumin can be released slowly in the liquid crystals. Therefore, based on the structural stability, protective effect on curcumin, and slow-release behavior, the constructed S1570-Brij97 lamellar liquid crystals have good potential for drug delivery.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 31271933
About the authors
Mr. Fumin Guo, Mr. Xuepeng Li, and Mr. Jun Fan, all Masters, graduated from College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University.
Mr. Fumin Guo, Mr. Xuepeng Li, and Mr. Jun Fan, all Masters, graduated from College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University.
Mr. Fumin Guo, Mr. Xuepeng Li, and Mr. Jun Fan, all Masters, graduated from College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University.
Mr. Xuebin Ma, Ph.D., received his Ph.D. from Nanjing University of Science and Technology in 2019. His main research interests include drug carriers, wound dressings, tissue engineering, etc.
Mrs. Zhongni Wang, Professor, teaches at College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, and her main research interests are the preparation of surfactant-ordered aggregates and their applications in biomedicine.
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Research ethics: The local Institutional Review Board deemed the study exempt from review.
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Author contributions: Fumin Guo carried out all experiments, and wrote the first draft of the manuscript. Fumin Guo, Xuepeng Li, and Jun Fan analyzed all data. Xuebin Ma: Writing-review & editing. Zhongni Wang: Conceptualization, Supervision. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: This work was supported by the National Natural Science Foundation of China (31271933).
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Data availability: The raw data can be obtained on request from the corresponding author.
References
1. Rajabalaya, R., Musa, M. N., Kifli, N., David, S. R. Oral and Transdermal Drug Delivery Systems: Role of Lipid-Based Lyotropic Liquid Crystals. Drug Des. Dev. Ther. 2017, 11, 393–406; https://doi.org/10.2147/dddt.s103505.Search in Google Scholar PubMed PubMed Central
2. Kim, D., Jahn, A., Cho, S., Kim, J. S., Ki, M., Kim, D. Lyotropic Liquid Crystal Systems in Drug Delivery: A Review. J. Pharm. Invest. 2015, 45, 1–11; https://doi.org/10.1007/s40005-014-0165-9.Search in Google Scholar
3. Hu, J., Ni, Z., Zhu, H., Li, H., Chen, Y., Shang, Y., Chen, D., Liu, H. A Novel Drug Delivery System–Drug Crystallization Encapsulated Liquid Crystal Emulsion. Int. J. Pharm. 2021, 607, 121007; https://doi.org/10.1016/j.ijpharm.2021.121007.Search in Google Scholar PubMed
4. Silvestrini, A. V. P., Caron, A. L., Viegas, J., Praça, F. G., Bentley, M. V. L. B. Advances in Lyotropic Liquid Crystal Systems for Skin Drug Delivery. Expert Opin. Drug Deliv. 2020, 17, 1781–1805; https://doi.org/10.1080/17425247.2020.1819979.Search in Google Scholar PubMed
5. Sadtler, V. M., Guely, M., Marchal, P., Choplin, L. Shear-Induced Phase Transitions in Sucrose Ester Surfactant. J. Colloid Interface Sci. 2004, 270, 270–275; https://doi.org/10.1016/j.jcis.2003.10.038.Search in Google Scholar PubMed
6. Fanun, M. Propylene Glycol and Ethoxylated Surfactant Effects on the Phase Behavior of Water/Sucrose Stearate/Oil System. J. Dispers. Sci. Technol. 2007, 28, 1244–1253; https://doi.org/10.1080/01932690701528159.Search in Google Scholar
7. Li, Z., Zhao, X., Wang, Z. Study on the Formation and Rheological Properties of Sucrose Stearate Lamellar Liquid Crystals. J. Dispers. Sci. Technol. 2017, 38, 152–158; https://doi.org/10.1080/01932691.2016.1147360.Search in Google Scholar
8. Liu, J., Wang, Z., Wang, M., Liu, X. The Effects of Some Factors on the Rheological Properties of the Lyotropic Liquid Crystals Formed in Brij97/NaDC/IPM/Water System: Compositions, Temperature and Polyphenols. J. Dispers. Sci. Technol. 2019, 40, 103–111; https://doi.org/10.1080/01932691.2018.1464471.Search in Google Scholar
9. Ma, X., Wang, Z., Guo, F., Li, Z., Wang, M., Zhou, W. Phase Behavior and Rheological Properties of Concentrated Lecithin Aqueous Solutions with Additives. J. Dispers. Sci. Technol. 2013, 34, 1540–1547; https://doi.org/10.1080/01932691.2012.752330.Search in Google Scholar
10. Wang, Z., Zhou, W. Lamellar Liquid Crystals of Brij 97 Aqueous Solutions Containing Different Additives. J. Solut. Chem. 2009, 38, 659–668; https://doi.org/10.1007/s10953-009-9399-y.Search in Google Scholar
11. Moniruzzaman, M., Min, T. Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition. Pharmaceutics 2020, 12, 447; https://doi.org/10.3390/pharmaceutics12050447.Search in Google Scholar PubMed PubMed Central
12. Setthacheewakul, S., Mahattanadul, S., Phadoongsombut, N., Pichayakorn, W., Wiwattanapatapee, R. Development and Evaluation of Self-Microemulsifying Liquid and Pellet Formulations of Curcumin, and Absorption Studies in Rats. Eur. J. Pharm. Biopharm. 2010, 76, 475–485; https://doi.org/10.1016/j.ejpb.2010.07.011.Search in Google Scholar PubMed
13. Zhang, H., Wang, Z. Phase Transition and Release Kinetics of Polyphenols Encapsulated Lyotropic Liquid Crystals. Int. J. Pharm. 2019, 565, 283–293; https://doi.org/10.1016/j.ijpharm.2019.05.021.Search in Google Scholar PubMed
14. Ke, W., Lin, S., Ho, H., Sheu, M. Physical Characterizations of Microemulsion Systems Using Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) as a Surfactant for the Oral Delivery of Protein Drugs. J. Control. Release 2005, 102, 489–507; https://doi.org/10.1016/j.jconrel.2004.10.030.Search in Google Scholar PubMed
15. Zheng, M., Wang, Z., Liu, F., Mi, Q., Wu, J. Study on the Microstructure and Rheological Property of Fish Oil Lyotropic Liquid Crystal. Colloids Surf. A Physicochem. Eng. Aspects 2011, 385, 47–54; https://doi.org/10.1016/j.colsurfa.2011.05.040.Search in Google Scholar
16. Almeida, P., Janmey, P. A., Kouwer, P. H. J. Fibrous Hydrogels under Multi-Axial Deformation: Persistence Length as the Main Determinant of Compression Softening. Adv. Funct. Mater. 2021, 31, 2010527; https://doi.org/10.1002/adfm.202010527.Search in Google Scholar
17. Youssrya, M., Coppolaa, L., Nicoteraa, I., Moránb, C. Swollen and Collapsed Lyotropic Lamellar Rheology. J. Colloid Interface Sci. 2008, 321, 459–467; https://doi.org/10.1016/j.jcis.2008.02.023.Search in Google Scholar PubMed
18. Ma, X., Ye, Z., Wang, Z. Lyotropic Liquid Crystal Formed in Aqueous Lecithin Solutions with IPM and AEO20 Additives. Tenside Surf. Det 2016, 53, 534–539; https://doi.org/10.3139/113.110468.Search in Google Scholar
19. Rochefort, W. E., Middleman, S. Rheology of Xanthan Gum: Salt, Temperature, and Strain Effects in Oscillatory and Steady Shear Experiments. J. Rheol. 1987, 31, 337–369; https://doi.org/10.1122/1.549953.Search in Google Scholar
20. Mongondry, P., Macosko, C. W., Moaddel, T. Rheology of Highly Concentrated Anionic Surfactants. Rheol. Acta 2006, 45, 891–898; https://doi.org/10.1007/s00397-006-0090-6.Search in Google Scholar
21. Wang, Z., Liu, F., Zhang, T., Wei, X., Zhou, W., Tang, X. Lyotropic Liquid Crystals Formed in Brij35/Copolymer/Water System. Tenside Surf. Det. 2012, 49, 225–230; https://doi.org/10.3139/113.110186.Search in Google Scholar
22. Dash, S., Murthy, P. N., Nath, L., Chowdhury, P. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Pol. Pharm. 2010, 67, 217–223.Search in Google Scholar
Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/tsd-2023-2569).
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