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Systemic immune- inflammation index predicts post-MI left ventricular remodeling

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Abstract

Aims

Previous studies demonstrated that remodeling after successful percutaneous coronary intervention (PCI) depends on the inflammatory response triggered by myocardial infarction (MI). The systemic immune-inflammation index (SII) is a novel inflammation index strongly associated with coronary artery disease. In our study, we sought to determine whether SII could predict Post-MI LV remodeling.

Methods and results

The study population included 528 patients (mean age 62.5 ± 10.2, 73% male) diagnosed with STEMI. Based on the increase in LVEDV within the first 12 months after STEMI, patients were divided into two groups. We categorized the ≥ 20% increase in LVEDV among remodelers (257 patients, 49%), and the other 271 patients (51%), as non-remodelers. To determine the relationship between laboratory parameters and LV remodeling, univariate and multivariate logistic regression models were used. In a univariate model, higher hs-CRP and SII values were associated with increased LVEDV. In a multivariate analysis, SII independently correlated with LV remodeling A cut-off value of 613.3 or higher for SII was significantly correlated with LV remodeling based on ROC analysis.

Conclusion

SII provides an easy-to-calculate and affordable biomarker for cardiovascular diseases. It may be used as a new biomarker to predict LV remodeling in patients with STEMI.

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Abbreviations

CAD:

Coronary artery disease

LV:

Left ventricle

ACS:

Acute coronary syndrome

DM:

Diabetes mellitus

HT:

Hypertension

PCI:

Percutaneous coronary intervention

ROC:

Receiver operating characteristic curve

ANOVA:

Analysis of variance

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Ankara Etlik Research Hospital, Ankara, Turkey

    Haci Ali Kurklu

  2. Department of Cardiovascular Medicine, Ankara University School of Medicine, Cebeci Kalp Merkezi, Mamak, Ankara, Turkey

    Turkan Seda Tan

Authors
  1. Haci Ali Kurklu
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  2. Turkan Seda Tan
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Contributions

All authors contributed to substantial contributions to conceptionand design of the data TST and HAK wrote the manucript and TST and HAK reviewed the manuscript.

Corresponding author

Correspondence to Turkan Seda Tan.

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conflicts of interest

The authors have no relevant relationships with the industry to disclose. No funding was received for this work. All authors declare that they do not have any conflicts of interest.

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We further confirm that any aspect of the work covered in this manuscript that has involved human patients has been conducted with the ethical approval of all relevant bodies and that such approvals are acknowledged within the manuscript. We confirm that the manuscript has been read and approved by all named authors.

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Kurklu, H.A., Tan, T.S. Systemic immune- inflammation index predicts post-MI left ventricular remodeling. Int J Cardiovasc Imaging (2024). https://doi.org/10.1007/s10554-024-03064-4

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