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Intermolecular Interactions of Cefotaxime with Sodium Alginate Biopolymer in Aqueous Solutions

  • Macromolecular Compounds and Polymeric Materials
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Abstract

The complexation of cefotaxime with an anionic polysaccharide, sodium alginate, in aqueous solutions with different pH values was studied by conductometry and by UV and IR spectroscopy. The compositions and stability constants of the complexes were determined. At pH 2.0, 5.6, and 7.2, the composition of the complex of cefotaxime with alginate corresponds to the [cefotaxime] : [alginate] molar ratio of 4.0 : 1.0, 2.3 : 1.0, and 1.0 : 1.0, respectively. The cefotaxime–alginate complex is most stable in strongly acidic media.

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Funding

The study was performed using the equipment of the Nanomaterials and Nanotechnologies Center for Shared Use, Kazan National Research University of Technology, and was financially supported by the Ministry of Science and Higher Education of the Russian Federation, project no. 0751520216999.

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Authors and Affiliations

  1. Kazan National Research University of Technology, Kazan, 420015, Tatarstan, Russia

    G. M. Mirgaleev, S. V. Shilova & V. P. Barabanov

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  1. G. M. Mirgaleev
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  2. S. V. Shilova
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  3. V. P. Barabanov
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Correspondence to S. V. Shilova.

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Translated from Zhurnal Prikladnoi Khimii, No. 4, pp. 350–357, August, 2023 https://doi.org/10.31857/S0044461823040047

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Mirgaleev, G.M., Shilova, S.V. & Barabanov, V.P. Intermolecular Interactions of Cefotaxime with Sodium Alginate Biopolymer in Aqueous Solutions. Russ J Appl Chem 96, 422–428 (2023). https://doi.org/10.1134/S1070427223040043

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  • DOI: https://doi.org/10.1134/S1070427223040043

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