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Synthesis, Characterization, and Study of Anticancer Activities of New Schiff Bases and 1,3-Oxazepine Containing Drug

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Abstract

Objective: This study involved the synthesis of new Schiff bases and 1,3-oxazepine derivatives from the baclofen drug and study the anticancer activities. Methods: Baclofen was initially reacted with aromatic aldehydes to create Schiff base derivatives (Ia–Ib), which were then closed in the next step using anhydrous acids to form oxazepine derivatives (IIa–IId). Results: The title compounds were synthesized successfully and identified using FT-IR, 1H NMR, and 13C NMR spectroscopy. Additionally, compound (IIc)’s (3-(4-chloro-phenyl)-4-[2-(4nitro-phenyl)-4,7-dioxo-4,7-dihydro-[1,3] oxazepin-3-yl]butyric acid) anticancer activity was assessed using MTT assay against FTC-133 (thyroid cancer) compared with WRL-68 (normal cell line). Discussion: The results showed that the viability of the FTC-133 cell was found to be greatest at 12.5 g/mL (96.52 ± 0.70) and lowest at 400 g/mL (35.378 ± 5.07). The effect of compound (IIc) on the normalizing of the WRL-68 cell line resulted in an IC50 for 62.39 ϻg/mL. Conclusions: It has been found that the compound (IIc) has good efficiency against thyroid cancer (FTC-133).

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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ACKNOWLEDGMENTS

The authors is thankful to Department of Chemistry at the College of Science, Iraq, for their help and cooperation throughout this research, and to the Biotechnology research centre at Al-Nahrain University, Iraq, for assistance with an anti-cancer assay.

Funding

This work was supported by regular institutional funding, and no additional grants were obtained.

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Authors and Affiliations

  1. Chemistry Department, College of Science, Baghdad University, 10001, Baghdad, Iraq

    Rana Abid Ali & Luma S. Ahamed

  2. Chemistry Department, College of Education for Pure Sciences, Kirkuk University, 36001, Kirkuk, Iraq

    Shaima Ibraheem Chyad AL-Khazraji

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  1. Rana Abid Ali
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  2. Luma S. Ahamed
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  3. Shaima Ibraheem Chyad AL-Khazraji
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Contributions

The author RAA—designed the experiments. The authors RAA and LSA synthesized the samples and carried out their electrochemical study.

All authors participated in data processing and contributed to manuscript preparation, and participated in the discussions.

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Correspondence to Rana Abid Ali.

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Ali, R.A., Ahamed, L.S. & AL-Khazraji, S.I.C. Synthesis, Characterization, and Study of Anticancer Activities of New Schiff Bases and 1,3-Oxazepine Containing Drug. Russ J Bioorg Chem 50, 28–33 (2024). https://doi.org/10.1134/S1068162024010102

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