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Genomic Imprinting and Random Monoallelic Expression

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Abstract

The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.

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Abbreviations

DMR:

differentially methylated region

ICR:

imprinting control region

SNP:

single nucleotide polymorphism

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Funding

This work was supported by the Russian Science Foundation (project no. 19-74-30026-P; genomic imprinting) and Ministry of Science and Higher Education of the Russian Federation (122041100149-7; random monoallelic expression).

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Authors and Affiliations

  1. Federal Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia

    Yaroslava V. Lobanova & Svetlana V. Zhenilo

  2. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    Yaroslava V. Lobanova

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  1. Yaroslava V. Lobanova
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  2. Svetlana V. Zhenilo
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Both authors wrote and edited the manuscript.

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Correspondence to Svetlana V. Zhenilo.

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Lobanova, Y.V., Zhenilo, S.V. Genomic Imprinting and Random Monoallelic Expression. Biochemistry Moscow 89, 84–96 (2024). https://doi.org/10.1134/S000629792401005X

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