Skip to main content
SpringerLink
Log in

Evaluation of the contralateral hemisphere with DWI in pediatric patients with Dyke–Davidoff–Masson syndrome

  • Original article
  • Published:
Acta Neurologica Belgica Aims and scope Submit manuscript

Abstract

Introduction

Dyke–Davidoff–Masson Syndrome (DDMS) is a clinical syndrome that causes different clinical symptoms and is defined by volume decrement in one cerebral hemisphere. In this study, we aimed to evaluate the involvement of the normal-appearing contralateral hemisphere in 16 pediatric patients with DDMS using diffusion-weighted imaging (DWI).

Materials and methods

Brain MRIs were retrospectively reviewed between January 2014 and January 2023. Sixteen pediatric patients radiologically compatible with DDMS were included in the study. Sixteen children who had undergone brain MRI, most commonly for headaches and whose MRI findings had been completely normal, were included as the control group. Apparent diffusion coefficient (ADC) values of the deep gray and white matter of the normal-appearing hemisphere in the patient group were calculated and compared with that of the control group.

Results

The ADC values of the gray and white matters of the patient and control groups were not statistically different. However, in the patient group, the ADC values of the gray and white matters in males were remarkably lower than in females (p = 0.038, p = 0.037, respectively).

Conclusion

The difference in the ADC values of the contralateral hemisphere between females and males in the patient group suggests that the normal-appearing hemisphere may have been affected by DDMS. Although, the exact mechanism of this effect is not known. Therefore, in patients with DDMS, contralateral hemisphere involvement in cerebral hemiatrophy and hemispherectomy should be evaluated clinically and radiologically.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

The datasets used and analyzed during the present study are obtainable from the corresponding author upon rational demand.

Abbreviations

ACA:

Anterior cerebral artery

ADC:

Apparent diffusion coefficient

DWI:

Diffusion weighted imaging

DDMS:

Dyke–Davidoff–Masson syndrome

MCA:

Middle cerebral artery

MRI:

Magnetic resonance imaging

PSA:

Posterior cerebral artery

References

  1. Tan AP, Wong YLJ, Lin BJ, Yong HRC, Mankad K (2018) Clinico-radiological approach to cerebral hemiatrophy. Childs Nerv Syst 34:2377–2390

    Article  PubMed  Google Scholar 

  2. Atalar MH, Icagasioglu D, Tas F (2007) Cerebral hemiatrophy (Dyke–Davidoff–Masson syndrome) in childhood: clinicoradiological analysis of 19 cases. Pediatr Int 49:70–75

    Article  PubMed  Google Scholar 

  3. Gökçe E, Beyhan M, Sade R (2017) Radiological imaging findings of Dyke–Davidoff–Masson syndrome. Acta Neurol Belg 117:885–893

    Article  PubMed  Google Scholar 

  4. Drake-Pérez M, Boto J, Fitsiori A, Lovblad K, Vargas MI (2018) Clinical applications of diffusion weighted imaging in neuroradiology. Insights Imaging 9:535–547

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dyke CG, Davidoff LM, Masson CB (1933) Cerebral hemiatrophy with homolateral hypertrophy of the skull and sinuses. Surg Gynecol Obstet 57:588–600

    Google Scholar 

  6. Tasdemir HA, Incesu L, Yazicioglu AK, Belet U, Gungor L (2002) Dyke–Davidoff–Masson syndrome. Clin Imaging 26:13–17

    Article  PubMed  Google Scholar 

  7. Behera MR, Patnaik S, Mohanty AK (2012) Dyke–Davidoff–Masson syndrome. J Neurosci Rural Pract 3:411–413

    Article  PubMed  PubMed Central  Google Scholar 

  8. Aneja J, Jangli S, Singh M, Mittal A (2015) Acquired Dyke–Davidoff–Masson syndrome (DDMS). Int J Adv Med Health Res 2:55–58

    Article  Google Scholar 

  9. Uduma FU, Emejulu JK, Motah M, Okere PC, Ongolo PC, Muna W (2013) Differential diagnoses of cerebral hemiatrophy in childhood: a review of literatur with illustrative report of two cases. Glob J Health Sci 5:195–207

    Article  PubMed  Google Scholar 

  10. Piro E, Piccione M, Marrone G, Giuffre M, Corsello G (2013) Dyke–Davidoff–Masson syndrome: case report of fetal unilateral ventriculomegaly and hypoplastic left middle cerebral artery. Ital J Pediatr 14:32

    Article  Google Scholar 

  11. Zamora CA, Kontzialis M (2015) Teaching neuroimages: Dyke–Davidoff–Masson in Sturge–Weber syndrome. Neurology 85:e128

    Article  PubMed  Google Scholar 

  12. Bekci T, Bilgici MC, Turgut E, Aslan K (2016) A rare combination: Sturge–Weber syndrome and accompanying Dyke-Davidoff–Masson syndrome. Acta Neurol Belg 116:79–81

    Article  PubMed  Google Scholar 

  13. Corey SA, O’Donovan CA (2005) Sturge–Weber syndrome and accompanying Dyke–Davidoff–Masson syndrome. Arch Neurol 62(12):1928–1929

  14. Gaillard F, Yap J, Fortin F et al (2023) Sturge-Weber syndrome. Reference article, Radiopaedia.org. https://doi.org/10.53347/rID-8210. Accessed 19 Nov 2023

  15. Öztoprak B, Öztoprak İ, Bozkurt H, Çiğdem B, Yıldız ÖK (2016) A DWI study of the contralateral hemisphere in cerebral hemiatrophy. J Neurol Sci 363:253–257

    Article  PubMed  Google Scholar 

  16. Koliatsos VE, Alexandris AS (2019) Wallerian degeneration as a therapeutic target in traumatic brain injury. Curr Opin Neurol 32:786–795

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Wakamoto H, Eluvathingal TJ, Makki M, Juhász C, Chugani HT (2006) Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 21:566–571

    Article  PubMed  Google Scholar 

  18. Xin J, Zhang Y, Tang Y, Yang Y (2019) Brain differences between men and women: evidence from deep learning. Front Neurosci 8:185

    Article  Google Scholar 

  19. Adamson MM, Main K, Harris OA, Kang X (2022) Sex differences in cortical thickness and diffusion properties in patients with traumatic brain injury: a pilot study. Brain Inj 21:488–502

    Article  Google Scholar 

  20. Keçeli AM (2021) Diffusion changes in cerebral white matter: the effect of age and gender. Hitit Med J 3:63–70

    Google Scholar 

  21. Lebel C, Treit S, Beaulieu C (2019) A review of diffusion MRI of typical white matter development from early childhood to young adulthood. NMR Biomed 32:e3778

    Article  PubMed  Google Scholar 

Download references

Funding

This study did not receive any funding or financial support.

Author information

Authors and Affiliations

  1. Sivas Cumhuriyet Universitesi, Sivas, Sivas, Turkey

    Enes Gul, Mehmet Haydar Atalar & Irfan Atik

Authors
  1. Enes Gul
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehmet Haydar Atalar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Irfan Atik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Enes Gul.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gul, E., Atalar, M.H. & Atik, I. Evaluation of the contralateral hemisphere with DWI in pediatric patients with Dyke–Davidoff–Masson syndrome. Acta Neurol Belg (2024). https://doi.org/10.1007/s13760-024-02473-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s13760-024-02473-5

Keywords

Search

Navigation