Mild and Efficient Preparation of N-Heterocyclic Organic Molecules by Catalyst-free and Solvent-free Methods

Title:Mild and Efficient Preparation of N-Heterocyclic Organic Molecules by Catalyst-free and Solvent-free Methods

Volume: 21

Author(s): Zhiqiang Wu*, Xuesong Li, Yueyi Li, Lin-an Cao, Zhenliang Li, Xuming Wang, Wanyi Liu and Enke Feng

Affiliation:

• School of Chemistry and Chemical Engineering; Key Laboratory of Green Catalytic Materials and Technology of Ningxia Province, Ningxia Normal University, Guyuan, 756000, P. R. China
• School of Civil and Hydraulic Engineering, Ningxia University, Yinchuan, 750021, P. R. China

Keywords: Catalyst-free, solvent-free, organic small molecules, synthetic preparation, N-heterocyclic derivatives.

Abstract: Aims: The small organic molecular compounds with biological activity containing C-C and C-N or C-O bonding were efficiently prepared without catalyst and solvent in the hydrothermal synthesis reactor.

Objectives: Our goal was to explore new applications for the more environmentally friendly and efficient synthesis of bis(indolyl)methyl, xanthene, quinazolinone, and N-heterocyclic derivatives in hydrothermal synthesis reactors under solvent-free and catalyst-free conditions.

Methods: A greener and more efficient method was successfully developed for the synthesis of bis(indolyl)methyl, heteroanthracene, quinazolinone, and N-heterocyclic derivatives using a hydrothermal synthesis reactor in a solvent- and catalyst-free manner.

Results: In a hydrothermal synthesis reactor, bis(indoyl)methyl, xanthene, quinazolinone, and N-heterocyclic derivatives were synthesized without catalysts and solvents.

Conclusion: Overall, it is proved once again that the catalyst-free and solvent-free synthesis method has universal value and is a more ideal and environmentally friendly new method, especially the hydrothermal reactor for synthesis.

Cite this article as:

Wu Zhiqiang*, Li Xuesong, Li Yueyi, Cao Lin-an, Li Zhenliang, Wang Xuming, Liu Wanyi and Feng Enke, Mild and Efficient Preparation of N-Heterocyclic Organic Molecules by Catalyst-free and Solvent-free Methods, Current Organic Synthesis 2024; 21 () . https://dx.doi.org/10.2174/0115701794285717240124053728