Comprehensive insights into the understanding of hypoxia in ameloblastoma
Ronell Bologna-Molina1,2, Lauren Schuch1 and Sven Eric Niklander3
1Diagnostic in Oral Pathology and Oral Medicine Department, Faculty of Dentistry, Universidad de la República, Uruguay, 2Research Department, School of Dentistry, Universidad Juarez del Estado de Durango, Mexico and 3Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Viña del Mar, Chile
Corresponding Author: Prof. Dr. Ronell Bologna-Molina, Diagnostic in Oral Pathology and Oral Medicine Department, Faculty of Dentistry, Universidad de la República, Uruguay. e-mail: ronellbologna@odon.edu.uy
Summary. Hypoxia is characterized by a disparity between supply and demand of oxygen. The association between hypoxia and head and neck tumors is a topic of significant interest. Tumors frequently encounter areas with inadequate oxygen supply, resulting in a hypoxic microenvironment.
Ameloblastoma is one of the most common benign odontogenic tumors of the maxillofacial region. It is a slow-growing but locally invasive tumor with a high recurrence rate. The literature has demonstrated the correlation between hypoxia and ameloblastoma, revealing a discernible link between the heightened expression of hypoxic markers in low oxygen conditions. This association is intricately tied to the tumoral potential for invasion, progression, and malignant transformation.
Hypoxia profoundly influences the molecular and cellular landscape within ameloblastic lesions. The present review sheds light on the mechanisms, implications, and emerging perspectives in understanding this intriguing association to clarify the dynamic relationship between hypoxia and ameloblastoma. Histol Histopathol
Key words: Ameloblastoma, Hypoxia, HIF-1a, Odontogenic tumors
DOI: 10.14670/HH-18-718
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©The Author(s) 2024. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
