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MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations

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Abstract

In this work, a sensitive and reproducible voltammetric methodology using a modified carbon paste electrode has been established for the determination of the non-steroidal anti-inflammatory drug ibuprofen. MWCNTs-supported Ni electrocatalyst was applied as a bulk carbon paste modifier to fabricate the Ni-MWCNTs-CPE sensor, while square-wave voltammetry was utilized as an electroanalytical technique. Besides, cyclic voltammetry was used to study the electrochemical behavior of ibuprofen on the proposed sensor. Parameters of square-wave voltammetry were optimized using acetate buffer pH 4.5 as an optimal electrolyte. In addition, the sensitivity of the modified carbon paste electrode, as a sensing element, was compared to the unmodified one. Under optimized conditions, a wide linear range was obtained with LOD and LOQ values of 0.86 and 2.61 µM, and 0.13 and 0.39 µM, for bare CPE and Ni-MWCNTs-CPE, respectively. The presence of the modifier in the paste improved the sensitivity of the carbon paste electrode by almost 7 times. In addition, the newly fabricated Ni-MWCNTs-CPE sensor showed better results in terms of precision (RSD up to 2.49%). Finally, the validated voltammetric methodology was successfully applied for the determination of ibuprofen content in pharmaceutical formulations, without any complicated preliminary preparation steps, with recovery values between 94.4 and 98.1%.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (project number 451-03-47/2023-01/ 200134).

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Authors and Affiliations

  1. Faculty of Technology Novi Sad, Department of Applied and Engineering Chemistry, University of Novi Sad, Bulevar cara Lazara 1, 21000, Novi Sad, Serbia

    Ana D. Đurović, Vuk V. Gudelj, Snežana Ž. Kravić & Zorica S. Stojanović

  2. Faculty of Technology Novi Sad, Department of Basic Engineering Disciplines, University of Novi Sad, Bulevar cara Lazara 1, 21000, Novi Sad, Serbia

    Sanja N. Panić

  3. Department of Chemistry and Biochemistry, Mendel University in Brno, Zemědělská 1, 613 00, Brno, Czech Republic

    Lukáš Richtera

  4. Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 612 00, Brno, Czech Republic

    Lukáš Richtera

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  1. Ana D. Đurović
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  2. Vuk V. Gudelj
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  3. Sanja N. Panić
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  4. Snežana Ž. Kravić
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  5. Lukáš Richtera
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  6. Zorica S. Stojanović
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Correspondence to Ana D. Đurović.

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Đurović, A.D., Gudelj, V.V., Panić, S.N. et al. MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations. Monatsh Chem 155, 131–141 (2024). https://doi.org/10.1007/s00706-023-03158-0

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