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Am J Perinatol
DOI: 10.1055/s-0044-1780531
Short Communication

NuMoM2b Study Insights: Primary Exposures, Outcomes, and Directions for Future Research

Leanna Kragenbrink
1   Department of Obstetrics and Gynaecology, Indiana University School of Medicine, Indianapolis, Indiana
,
Claire M. Schopper
1   Department of Obstetrics and Gynaecology, Indiana University School of Medicine, Indianapolis, Indiana
,
Rebecca B. McNeil
2   Research Triangle International, Raleigh, North Carolina
,
William A. Grobman
3   Department of Obstetrics and Gynaecology, The Ohio State University School of Medicine, Columbus, Ohio
,
Robert M. Silver
4   Department of Obstetrics and Gynaecology, University of Utah School of Medicine, Salt Lake City, Utah
,
David M. Haas 
1   Department of Obstetrics and Gynaecology, Indiana University School of Medicine, Indianapolis, Indiana
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Abstract

Objective To summarize the publications to date from a large obstetric cohort of nulliparous individuals.

Study design We summarized all of the publications from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b). We descriptively summarized the most common outcomes and exposures reported in current publications.

Results Fifty-six publications to date are discussed. The most common primary exposures reported are participant baseline characteristics such as body mass index (24%), sociodemographic characteristics (22%), and sleep factors (16%). These exposures were most commonly measured in the first trimester (77%). The most commonly reported primary outcomes were related to adverse pregnancy outcomes (APOs, 51.6%), with 25% using a composite of multiple APOs as the primary outcome. At least 8,000 participants were used in the analyses of over half of the publications.

Conclusion The nuMoM2b study has generated a diverse array of publications and conclusions on factors associated with APOs. The publicly available data set from the nuMoM2b study continues to hold potential for considerable advances, new insights, and future research opportunities to optimize pregnancy and pregnancy-related health.

Key Points

  • The nuMoM2b pregnancy cohort has generated 56 publications thus far.

  • The main findings of these publications are summarized and categorized in this work.

  • The data and specimens from this cohort are available and can answer many clinical questions.

Keywords

pregnancy - outcomes - publications - exposures - adverse pregnancy outcomes - nuMoM2b

Authors' Contribution

All authors contributed to the conceptualization, design, and writing/editing of this manuscript. All authors approved this final version.




Publication History

Received: 02 January 2024

Accepted: 28 January 2024

Article published online:
19 February 2024

© 2024. Thieme. All rights reserved.

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  • References

  • 1 ACOG Practice Bulletin No. 202: Gestational hypertension and preeclampsia. Obstet Gynecol 2019; 133 (01) e1-e25
    CrossrefPubMedGoogle Scholar
  • 2 Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Gestational diabetes: development of an early risk prediction tool to facilitate opportunities for prevention. Aust N Z J Obstet Gynaecol 2011; 51 (06) 499-504
    CrossrefPubMedGoogle Scholar
  • 3 Prediction and Prevention of Spontaneous Preterm Birth. Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234. Obstet Gynecol 2021; 138 (02) e65-e90
    CrossrefPubMedGoogle Scholar
  • 4 Haas DM, Parker CB, Wing DA. et al; NuMoM2b study. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol 2015; 212 (04) 539.e1-539.e24
    CrossrefPubMedGoogle Scholar
  • 5 Haas DM, Ehrenthal DB, Koch MA. et al; National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network. Pregnancy as a window to future cardiovascular health: design and implementation of the nuMoM2b Heart Health Study. Am J Epidemiol 2016; 183 (06) 519-530
    CrossrefPubMedGoogle Scholar