Abstract
Background
Acceleration of atherogenesis is an aftermath of cardiovascular diseases (CVDs), which arise with mitochondrial dysfunction (MD). Endothelium restraint inflammation, repair and fluidic exchange with nearby tissues. Endothelium-mediated mitochondrial damage can trigger the molecular mechanisms of vasodilation, pro-inflammation and process of pro-thrombotic accumulation in microvascular endothelial layer. The oxidation of lipid particles generates modified lipoproteins. Modification of mitochondrial function recently emerged a great concern towards the atherosclerosis initiation and progression, because the powerhouse of energy production mitochondria mutation can release mtDNA into cytoplasm and it can be act as sensor for viral DNA or foreign DNA. Another cause is mitochondrial imbalance can lead to product excess amount of reactive oxygen species (ROS) which can cause cellular metabolism and respiration system.
Objectives
In previous some studies showed that mitochondrial dysfunction plays a vital role in term of cardiac diseases. However, very few studies provide evidence of endothelium-mediated mitochondrial imbalance. This study investigated the potential involvement of mitochondrial impairment in cardiotoxicity using a series of mechanistic endpoints, including mitochondrial respiration and endothelial suppression of inflammation, mitochondrial DNA. Our study provides some molecular mechanisms regarding mitochondrial role in endothelium function. In each section, we are trying to introduce key concepts and then analysis previous studies revealed the importance of that molecular mechanism regarding mitochondrial dysfunction.
Conclusions
The ultimate goal of our review is to find out the novel drug discovery or new approaches of therapy. Our review will target different aspects of mitochondrial protein function and their effect of endothelial and cause of atherosclerosis diseases. To evaluate the healthy lifestyle and better condition of mitochondrial balance nowadays it is urgent to utilize the proper function for therapeutical effect for future direction.
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Abbreviations
- CVD:
-
Cardiovascular diases
- MD:
-
Mitochondrial dysfunction
- LDL:
-
Low density lipoprotein
- Ox-LDL:
-
Oxidase low density lipoprotein
- NO:
-
Nitric oxide
- VSMC:
-
Vascular smooth muscle cell
- PLGA NP:
-
Poly (lactide–co-glycolide) copolymers nano particles
- HDL:
-
High-density lipoprotein
- IVUS:
-
Intravascular ultrasound
References
Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM (2007) L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis 192(1):56–66
Ahmed T, Islam MN, Monalisa R, Ehsan F, Huang SW (2023) Polysaccharides polymers for glaucoma treatment-a review. Eur J Ophthalmol. https://doi.org/10.1177/11206721231178057
Ait-Oufella H, Taleb S, Mallat Z, Tedgui A (2011) Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol 31(5):969–979
Akar FG, Aon MA, Tomaselli GF, O’Rourke B (2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest 115(12):3527–3535
Alonso R, Mata P, Muniz O, Fuentes-Jimenez F, Diaz JL, Zambon D, Tomas M, Martin C, Moyon T, Croyal M, Thedrez A, Lambert G (2016) PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia. Atherosclerosis 254:249–253
Anderson TJ (1999) Assessment and treatment of endothelial dysfunction in humans. J Am Coll Cardiol 34(3):631–638
Andrews HE, Bruckdorfer KR, Dunn RC, Jacobs M (1987) Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature 327(6119):237–239
Aon MA, Cortassa S, Maack C, O’Rourke B (2007) Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem 282(30):21889–21900
Asanuma Y, Oeser A, Shintani AK, Turner E, Olsen N, Fazio S, Linton MF, Raggi P, Stein CM (2003) Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med 349(25):2407–2415
Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL (2016) The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. Clin Sci (lond) 130(21):1861–1874
Ayoub C, Erthal F, Abdelsalam MA, Murad MH, Wang Z, Erwin PJ, Hillis GS, Kritharides L, Chow BJW (2017) Prognostic value of segment involvement score compared to other measures of coronary atherosclerosis by computed tomography: a systematic review and meta-analysis. J Cardiovasc Comput Tomogr 11(4):258–267
Back M (2009) Leukotriene signaling in atherosclerosis and ischemia. Cardiovasc Drugs Ther 23(1):41–48
Ballinger SW, Patterson C, Yan CN, Doan R, Burow DL, Young CG, Yakes FM, Van Houten B, Ballinger CA, Freeman BA, Runge MS (2000) Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res 86(9):960–966
Ballinger SW, Patterson C, Knight-Lozano CA, Burow DL, Conklin CA, Hu Z, Reuf J, Horaist C, Lebovitz R, Hunter GC, McIntyre K, Runge MS (2002) Mitochondrial integrity and function in atherogenesis. Circulation 106(5):544–549
Beer M, Seyfarth T, Sandstede J, Landschutz W, Lipke C, Kostler H, von Kienlin M, Harre K, Hahn D, Neubauer S (2002) Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol 40(7):1267–1274
Benard G, Karbowski M (2009) Mitochondrial fusion and division: regulation and role in cell viability. Semin Cell Dev Biol 20(3):365–374
Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ (2016) Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T Cell Exhaustion. Immunity 45(2):358–373
Benitez S, Ordonez-Llanos J, Franco M, Marin C, Paz E, Lopez-Miranda J, Otal C, Perez-Jimenez F, Sanchez-Quesada JL (2004) Effect of simvastatin in familial hypercholesterolemia on the affinity of electronegative low-density lipoprotein subfractions to the low-density lipoprotein receptor. Am J Cardiol 93(4):414–420
Benitez S, Camacho M, Bancells C, Vila L, Sanchez-Quesada JL, Ordonez-Llanos J (2006) Wide proinflammatory effect of electronegative low-density lipoprotein on human endothelial cells assayed by a protein array. Biochim Biophys Acta 1761(9):1014–1021
Benitez S, Bancells C, Ordonez-Llanos J, Sanchez-Quesada JL (2007) Pro-inflammatory action of LDL(-) on mononuclear cells is counteracted by increased IL10 production. Biochim Biophys Acta 1771(5):613–622
Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelan I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL (1995) Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. J Biol Chem 270(10):5191–5197
Berbee JF, Wong MC, Wang Y, van Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC (2013) Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE3-LeidenCETP mice. J Nutr Biochem 24(8):1423–1430
Berg AH, Scherer PE (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96(9):939–949
Bergman RN, Ader M (2000) Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11(9):351–356
Bertrand MJ, Tardif JC (2017) Inflammation and beyond: new directions and emerging drugs for treating atherosclerosis. Expert Opin Emerg Drugs 22(1):1–26
Bhatt MP, Lim YC, Kim YM, Ha KS (2013) C-peptide activates AMPKalpha and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes 62(11):3851–3862
Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta Mol Basis Dis 1863(5):1066–1077
Boden G, Chen X, Ruiz J, White JV, Rossetti L (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93(6):2438–2446
Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin MA, Morio B, Vidal H, Rieusset J (2008) Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 118(2):789–800
Bosc C, Broin N, Fanjul M, Saland E, Farge T, Courdy C, Batut A, Masoud R, Larrue C, Skuli S, Espagnolle N, Pages JC, Carrier A, Bost F, Bertrand-Michel J, Tamburini J, Recher C, Bertoli S, Mansat-De Mas V, Manenti S, Sarry JE, Joffre C (2020) Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites. Nat Commun 11(1):4056
Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhausl W, Roden M (2006) Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 55(1):136–140
Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232(4746):34–47
Brown DA, Aon MA, Frasier CR, Sloan RC, Maloney AH, Anderson EJ, O’Rourke B (2010) Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. J Mol Cell Cardiol 48(4):673–679
Buck MD, O’Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O’Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL (2016) Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 166(1):63–76
Bugger H, Abel ED (2010) Mitochondria in the diabetic heart. Cardiovasc Res 88(2):229–240
Camara AK, Bienengraeber M, Stowe DF (2011) Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol 2:13
Cannon RO 3rd (1998) Role of nitric oxide in cardiovascular disease: focus on the endothelium. Clin Chem 44(8 Pt 2):1809–1819
Carmena R, Duriez P, Fruchart JC (2004) Atherogenic lipoprotein particles in atherosclerosis. Circulation 109(23):2–7
Chan DC (2012) Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 46:265–287
Chang PY, Chen YJ, Chang FH, Lu J, Huang WH, Yang TC, Lee YT, Chang SF, Lu SC, Chen CH (2013) Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction. Cardiovasc Res 99(1):137–145
Charo IF, Taub R (2011) Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov 10(5):365–376
Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294(5548):1866–1870
Chen M, Nagase M, Fujita T, Narumiya S, Masaki T, Sawamura T (2001) Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun 287(4):962–968
Chen M, Masaki T, Sawamura T (2002) LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 95(1):89–100
Chen CH, Jiang T, Yang JH, Jiang W, Lu J, Marathe GK, Pownall HJ, Ballantyne CM, McIntyre TM, Henry PD, Yang CY (2003) Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation 107(16):2102–2108
Chen XP, Xun KL, Wu Q, Zhang TT, Shi JS, Du GH (2007) Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species. Vascul Pharmacol 47(1):1–9
Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA (2012) OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc 1(5):e003012
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303(5660):1010–1014
Chourasia AH, Boland ML, Macleod KF (2015) Mitophagy and cancer. Cancer Metab 3:4
Chu CS, Ke LY, Chan HC, Chan HC, Chen CC, Cheng KH, Lee HC, Kuo HF, Chang CT, Chang KC, Sheu SH, Chen CH, Lai WT (2016) Four statin benefit groups defined by the 2013 ACC/AHA new cholesterol guideline are characterized by increased plasma level of electronegative low-density lipoprotein. Acta Cardiol Sin 32(6):667–675
Chung CP, Solus JF, Oeser A, Li C, Raggi P, Smith JR, Stein CM (2014) Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus. Lupus 23(9):876–880
Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD (1988) Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res 63(5):903–910
Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, Rigoni A, Pastorino AM, Lo Cascio V, Sawamura T (2000) Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 275(17):12633–12638
Cui Y, Xu X, Bi H, Zhu Q, Wu J, Xia X, Qiushi R, Ho PC (2006) Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy. Exp Eye Res 83(4):807–816
Currie B, Kevau I, Naraqi S (1989) Acute myocardial infarction in a young Papuan woman with systemic lupus erythematosus. P N G Med J 32(3):181–184
Dai L, Zhang Z, Winyard PG, Gaffney K, Jones H, Blake DR, Morris CJ (1997) A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radic Biol Med 22(4):705–710
Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116(2):205–219
Daniele G, Guardado Mendoza R, Winnier D, Fiorentino TV, Pengou Z, Cornell J, Andreozzi F, Jenkinson C, Cersosimo E, Federici M, Tripathy D, Folli F (2014) The inflammatory status score including IL-6, TNF-alpha, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetol 51(1):123–131
Davignon J, Ganz P (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109(23):III27-32
De Castellarnau C, Sanchez-Quesada JL, Benitez S, Rosa R, Caveda L, Vila L, Ordonez-Llanos J (2000) Electronegative LDL from normolipemic subjects induces IL-8 and monocyte chemotactic protein secretion by human endothelial cells. Arterioscler Thromb Vasc Biol 20(10):2281–2287
de Grey AD (1997) A proposed refinement of the mitochondrial free radical theory of aging. BioEssays 19(2):161–166
de Grey AD (2002) The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief. Eur J Biochem 269(8):2003–2009
de Sousa IF, Pedroso AP, de Andrade IS, Boldarine VT, Tashima AK, Oyama LM, Lionetti L, Ribeiro EB (2021) High-fat but not normal-fat intake of extra virgin olive oil modulates the liver proteome of mice. Eur J Nutr 60(3):1375–1388
Dedonder-Decoopman E, Fievet-Desreumaux C, Campos E, Moulin S, Dewailly P, Sezille G, Jaillard J (1980) Plasma levels of VLDL- + LDL-cholesterol, HDL-cholesterol, triglycerides and apoproteins B and A-I in a healthy population–influence of several risk factors. Atherosclerosis 37(4):559–568
Denk A, Goebeler M, Schmid S, Berberich I, Ritz O, Lindemann D, Ludwig S, Wirth T (2001) Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J Biol Chem 276(30):28451–28458
Dhananjayan R, Koundinya KS, Malati T, Kutala VK (2016) Endothelial dysfunction in type 2 diabetes mellitus. Indian J Clin Biochem 31(4):372–379
Di Pietro N, Formoso G, Pandolfi A (2016) Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis. Vascul Pharmacol 84:1–7
Dirkx E, Schwenk RW, Coumans WA, Hoebers N, Angin Y, Viollet B, Bonen A, van Eys GJ, Glatz JF, Luiken JJ (2012) Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes. J Biol Chem 287(8):5871–5881
Doi K, Noiri E (2016) Mitochondrial dysfunction in cardiorenal syndrome. Antioxid Redox Signal 25(4):200–207
Dose J, Huebbe P, Nebel A, Rimbach G (2016) APOE genotype and stress response - a mini review. Lipids Health Dis 15:121
Dromparis P, Michelakis ED (2013) Mitochondria in vascular health and disease. Annu Rev Physiol 75:95–126
Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M (2000) Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA 97(22):12222–12226
Duchen MR (2004) Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med 25(4):365–451
Dymkowska D, Drabarek B, Podszywalow-Bartnicka P, Szczepanowska J, Zablocki K (2014) Hyperglycaemia modifies energy metabolism and reactive oxygen species formation in endothelial cells in vitro. Arch Biochem Biophys 542:7–13
Faelber K, Posor Y, Gao S, Held M, Roske Y, Schulze D, Haucke V, Noe F, Daumke O (2011) Crystal structure of nucleotide-free dynamin. Nature 477(7366):556–560
Favero G, Paganelli C, Buffoli B, Rodella LF, Rezzani R (2014) Endothelium and its alterations in cardiovascular diseases: life style intervention. Biomed Res Int 2014:801896
Fernyhough P, Roy Chowdhury SK, Schmidt RE (2010) Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Rev Endocrinol Metab 5(1):39–49
Ferrari R (1996) The role of mitochondria in ischemic heart disease. J Cardiovasc Pharmacol 28(Suppl 1):S1-10
Filadi R, Pendin D, Pizzo P (2018) Mitofusin 2: from functions to disease. Cell Death Dis 9(3):330
Fishman AP (1982) Endothelium: a distributed organ of diverse capabilities. Ann N Y Acad Sci 401:1–8
Forner F, Foster LJ, Campanaro S, Valle G, Mann M (2006) Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver. Mol Cell Proteomics 5(4):608–619
Fors Nieves CE, Izmirly PM (2016) Mortality in Systemic Lupus Erythematosus: an Updated Review. Curr Rheumatol Rep 18(4):21
Fu Z, Yuskavage J, Liu D (2013) Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J Agric Food Chem 61(18):4303–4309
Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG (2012) Role of mitofusin 2 in the renal stress response. PLoS ONE 7(1):e31074
Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G (2006) Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 13(9):1423–1433
Giacomello M, Pyakurel A, Glytsou C, Scorrano L (2020) The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21(4):204–224
Gimbrone MA Jr (1976) Culture of vascular endothelium. Prog Hemost Thromb 3:1–28
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics, C., Stroke Statistics, S (2013) Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 127(1):e6–e245
Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D’Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O’Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC Jr, Sorlie P, Stone NJ, Wilson PW, Jordan HS, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF, American College of Cardiology/American Heart Association Task Force on Practice, G (2014a) 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 129(25 Suppl 2):S49-73
Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D’Agostino RB Sr, Gibbons R, Greenland P, Lackland DT, Levy D, O’Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC Jr, Sorlie P, Stone NJ, Wilson PWF (2014b) 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63(25):2935–2959
Goldstein JL, Brown MS (2001) Molecular medicine. The cholesterol quartet. Science 292(5520):1310–1312
Gorman GS, Chinnery PF, DiMauro S, Hirano M, Koga Y, McFarland R, Suomalainen A, Thorburn DR, Zeviani M, Turnbull DM (2016) Mitochondrial diseases. Nat Rev Dis Primers 2:16080
Granger DN, Rodrigues SF, Yildirim A, Senchenkova EY (2010) Microvascular responses to cardiovascular risk factors. Microcirculation 17(3):192–205
Green DR, Galluzzi L, Kroemer G (2011) Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333(6046):1109–1112
Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SC Jr, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Smith SC Jr, Anderson JL, Albert N, Buller CE, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Nishimura R, Ohman EM, Page RL, Stevenson WG, Tarkington LG, Yancy CW, American College of Cardiology, F., American Heart, A (2010) 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 56(25):e50-103
Guo H, Callaway JB, Ting JP (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21(7):677–687
Hahn BH (2003) Systemic lupus erythematosus and accelerated atherosclerosis. N Engl J Med 349(25):2379–2380
Hall AR, Burke N, Dongworth RK, Hausenloy DJ (2014) Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease. Br J Pharmacol 171(8):1890–1906
Hamblin M, Smith HM, Hill MF (2007) Dietary supplementation with vitamin E ameliorates cardiac failure in type I diabetic cardiomyopathy by suppressing myocardial generation of 8-iso-prostaglandin F2alpha and oxidized glutathione. J Card Fail 13(10):884–892
Han CB, Ma JM, Xin Y, Mao XY, Zhao YJ, Wu DY, Zhang SM, Zhang YK (2005) Mutations of mitochondrial 12S rRNA in gastric carcinoma and their significance. World J Gastroenterol 11(1):31–35
Handschin C, Spiegelman BM (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27(7):728–735
Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16):1685–1695
Heidari MM, Derakhshani M, Sedighi F, Foruzan-Nia SK (2017) Mutation analysis of the mitochondrial tRNA Genes in Iranian coronary atherosclerosis patients. Iran J Public Health 46(10):1379–1385
Henne WM, Reese ML, Goodman JM (2018) The assembly of lipid droplets and their roles in challenged cells. EMBO J. https://doi.org/10.15252/embj.201898947
Higashi Y (2015) Assessment of endothelial function. History, methodological aspects, and clinical perspectives. Int Heart J 56(2):125–134
Hirowatari Y, Homma Y, Yoshizawa J, Homma K (2012) Increase of electronegative-LDL-fraction ratio and IDL-cholesterol in chronic kidney disease patients with hemodialysis treatment. Lipids Health Dis 11:111
Hoogeboom D, Burgering BM (2009) Should I stay or should I go: beta-catenin decides under stress. Biochim Biophys Acta 1796(2):63–74
Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109(9):1125–1131
Hu CL, Nydes M, Shanley KL, Morales Pantoja IE, Howard TA, Bizzozero OA (2019) Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurochem 148(3):426–439
Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J (2014) New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev 2014:210934
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J (2015) Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res 116(2):264–278
Ikegami Y, Inoue I, Inoue K, Shinoda Y, Iida S, Goto S, Nakano T, Shimada A, Noda M (2018) The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy. NPJ Aging Mech Dis 4:7
Inoue T, Yaguchi I, Uchida T, Kamishirado H, Nakahara S, Hayashi T, Morooka S (2002) Clinical significance of the antibody against oxidized low-density lipoprotein in acute myocardial infarction. Cardiology 98(1–2):13–17
Ippolito A, Petri M (2008) An update on mortality in systemic lupus erythematosus. Clin Exp Rheumatol 26(5 Suppl 51):S72-79
Ishihara N, Otera H, Oka T, Mihara K (2013) Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammals. Antioxid Redox Signal 19(4):389–399
Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J, Egashira K (2016) Nanoparticle-mediated delivery of mitochondrial division inhibitor 1 to the myocardium protects the heart from ischemia-reperfusion injury through inhibition of mitochondria outer membrane permeabilization: a new therapeutic modality for acute myocardial infarction. J Am Heart Assoc. https://doi.org/10.1161/JAHA.116.003872
Ivanov S, Roy CR (2009) NDP52: the missing link between ubiquitinated bacteria and autophagy. Nat Immunol 10(11):1137–1139
James DI, Parone PA, Mattenberger Y, Martinou JC (2003) hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 278(38):36373–36379
Jana BA, Chintamaneni PK, Krishnamurthy PT, Wadhwani A, Mohankumar SK (2019) Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: a molecular insight. Mol Biol Rep 46(1):957–963
Jin Y, Fu J (2019) Novel Insights Into the NLRP 3 Inflammasome in Atherosclerosis. J Am Heart Assoc 8(12):e012219
Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, Ma S, Zhu H, Ren J, Zhou H (2018) DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol 14:576–587
Jin JY, Wei XX, Zhi XL, Wang XH, Meng D (2021) Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacol Sin 42(5):655–664
Jornot L, Maechler P, Wollheim CB, Junod AF (1999) Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger. J Cell Sci 112(Pt 7):1013–1022
Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444(7121):840–846
Kaludercic N, Giorgio V (2016) The dual function of reactive oxygen/nitrogen species in bioenergetics and cell death: the role of ATP synthase. Oxid Med Cell Longev 2016:3869610
Kandel-Kfir M, Almog T, Shaish A, Shlomai G, Anafi L, Avivi C, Barshack I, Grosskopf I, Harats D, Kamari Y (2015) Interleukin-1alpha deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice. J Hepatol 63(4):926–933
Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A, Di Angelantonio E, Gudnason V, Rumley A, Lowe GD, Jorgensen T, Danesh J (2014) Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J 35(9):578–589
Karbowski M, Arnoult D, Chen H, Chan DC, Smith CL, Youle RJ (2004) Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol 164(4):493–499
Karnovsky MJ (1967) The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J Cell Biol 35(1):213–236
Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA, Murphy MP (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 276(7):4588–4596
Kim JA (2008) Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial dysfunction. Endocr Metab Immune Disord Drug Targets 8(2):82–88
Kjekshus J, Apetrei E, Barrios V, Bohm M, Cleland JG, Cornel JH, Dunselman P, Fonseca C, Goudev A, Grande P, Gullestad L, Hjalmarson A, Hradec J, Janosi A, Kamensky G, Komajda M, Korewicki J, Kuusi T, Mach F, Mareev V, McMurray JJ, Ranjith N, Schaufelberger M, Vanhaecke J, van Veldhuisen DJ, Waagstein F, Wedel H, Wikstrand J, Group C (2007) Rosuvastatin in older patients with systolic heart failure. N Engl J Med 357(22):2248–2261
Kleemann R, Zadelaar S, Kooistra T (2008) Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res 79(3):360–376
Knowlton AA, Chen L, Malik ZA (2014) Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies. J Cardiovasc Pharmacol 63(3):196–206
Koba S, Hirano T, Ito Y, Tsunoda F, Yokota Y, Ban Y, Iso Y, Suzuki H, Katagiri T (2006) Significance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseases. Atherosclerosis 189(1):206–214
Kok BP, Venkatraman G, Capatos D, Brindley DN (2012) Unlike two peas in a pod: lipid phosphate phosphatases and phosphatidate phosphatases. Chem Rev 112(10):5121–5146
Kopsidas G, Kovalenko SA, Heffernan DR, Yarovaya N, Kramarova L, Stojanovski D, Borg J, Islam MM, Caragounis A, Linnane AW (2000) Tissue mitochondrial DNA changes. A stochastic system. Ann N Y Acad Sci 908:226–243
Korkmaz C, Cansu DU, Kasifoglu T (2007) Myocardial infarction in young patients (< or =35 years of age) with systemic lupus erythematosus: a case report and clinical analysis of the literature. Lupus 16(4):289–297
Koziel A, Woyda-Ploszczyca A, Kicinska A, Jarmuszkiewicz W (2012) The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells. Pflug Arch 464(6):657–669
Koziel R, Pircher H, Kratochwil M, Lener B, Hermann M, Dencher NA, Jansen-Durr P (2013) Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4. Biochem J 452(2):231–239
Krintus M, Kozinski M, Kubica J, Sypniewska G (2014) Critical appraisal of inflammatory markers in cardiovascular risk stratification. Crit Rev Clin Lab Sci 51(5):263–279
Kruszynska YT, Mulford MI, Yu JG, Armstrong DA, Olefsky JM (1997) Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion. Diabetes 46(10):1586–1593
Kubera M, Obuchowicz E, Goehler L, Brzeszcz J, Maes M (2011) In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry 35(3):744–759
Kuhnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, Peyman A, Schafer HL, Schwahn U, Jukema JW, Princen HM (2014) Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. J Lipid Res 55(10):2103–2112
Kumar S, Lombard DB (2015) Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal 22(12):1060–1077
Kundu M, Thompson CB (2008) Autophagy: basic principles and relevance to disease. Annu Rev Pathol 3:427–455
Kuznetsov AV, Hermann M, Saks V, Hengster P, Margreiter R (2009) The cell-type specificity of mitochondrial dynamics. Int J Biochem Cell Biol 41(10):1928–1939
Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM (1999) C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 4(5):815–826
Lacy M, Atzler D, Liu R, de Winther M, Weber C, Lutgens E (2019) Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis. Pharmacol Ther 193:50–62
Leaw B, Nair S, Lim R, Thornton C, Mallard C, Hagberg H (2017) Mitochondria, bioenergetics and excitotoxicity: new therapeutic targets in perinatal brain injury. Front Cell Neurosci 11:199
Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ (2004) Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 15(11):5001–5011
Lee SJ, Zhang J, Choi AM, Kim HP (2013) Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress. Oxid Med Cell Longev 2013:327167
Li H, Forstermann U (2000) Nitric oxide in the pathogenesis of vascular disease. J Pathol 190(3):244–254
Li D, Mehta JL (2009) Intracellular signaling of LOX-1 in endothelial cell apoptosis. Circ Res 104(5):566–568
Li D, Yang B, Mehta JL (1998) Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am J Physiol 275(2):H568-576
Li D, Williams V, Liu L, Chen H, Sawamura T, Romeo F, Mehta JL (2003) Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction. J Am Coll Cardiol 41(6):1048–1055
Li B, Li W, Li X, Zhou H (2017) Inflammation: a novel therapeutic target/direction in atherosclerosis. Curr Pharm Des 23(8):1216–1227
Liao Y, Dong Y, Cheng J (2017) The function of the mitochondrial calcium uniporter in neurodegenerative disorders. Int J Mol Sci 18(2):248
Libby P (2002) Inflammation in atherosclerosis. Nature 420(6917):868–874
Lin J, Kakkar V, Lu X (2014) Impact of MCP-1 in atherosclerosis. Curr Pharm Des 20(28):4580–4588
Lin P, Liu J, Ren M, Ji K, Li L, Zhang B, Gong Y, Yan C (2015) Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3beta/beta-catenin signalling pathways. Biochem Biophys Res Commun 465(3):548–555
Liu YJ, McIntyre RL, Janssens GE, Houtkooper RH (2020) Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease. Mech Ageing Dev 186:111212
Lobo JC, Mafra D, Farage NE, Faulin Tdo E, Abdalla DS, de Nobrega AC, Torres JP (2011) Increased electronegative LDL and decreased antibodies against electronegative LDL levels correlate with inflammatory markers and adhesion molecules in hemodialysed patients. Clin Chim Acta 412(19–20):1788–1792
Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF (2016) Intermedin1-53 attenuates abdominal aortic aneurysm by inhibiting oxidative stress. Arterioscler Thromb Vasc Biol 36(11):2176–2190
Lubrano V, Balzan S (2015) Consolidated and emerging inflammatory markers in coronary artery disease. World J Exp Med 5(1):21–32
Lum H, Roebuck KA (2001) Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 280(4):C719-741
Ma K, Chen G, Li W, Kepp O, Zhu Y, Chen Q (2020) Mitophagy, Mitochondrial Homeostasis, and Cell Fate. Front Cell Dev Biol 8:467
Mahley RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240(4852):622–630
Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM (2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J 23(2):586–604
Mallat Z, Taleb S, Ait-Oufella H, Tedgui A (2009) The role of adaptive T cell immunity in atherosclerosis. J Lipid Res 50(Suppl):S364-369
Manderson AP, Botto M, Walport MJ (2004) The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 22:431–456
Manolis AS, Manolis AA, Manolis TA, Apostolaki NE, Apostolopoulos EJ, Melita H, Katsiki N (2021) Mitochondrial dysfunction in cardiovascular disease: current status of translational research/clinical and therapeutic implications. Med Res Rev 41(1):275–313
Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM (2008) Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 44(7):1259–1272
Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium 69:62–72
Marian AJ (2012) The enigma of genetics etiology of atherosclerosis in the post-GWAS era. Curr Atheroscler Rep 14(4):295–299
Marin-Garcia J, Akhmedov AT (2016) Mitochondrial dynamics and cell death in heart failure. Heart Fail Rev 21(2):123–136
Mattu A, Petrini J, Swencki S, Chaudhari C, Brady WJ (2005) Premature atherosclerosis and acute coronary syndrome in systemic lupus erythematosus. Am J Emerg Med 23(5):696–703
McKenzie M, Liolitsa D, Hanna MG (2004) Mitochondrial disease: mutations and mechanisms. Neurochem Res 29(3):589–600
McLeod DS, Lefer DJ, Merges C, Lutty GA (1995) Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol 147(3):642–653
McNew JA, Sondermann H, Lee T, Stern M, Brandizzi F (2013) GTP-dependent membrane fusion. Annu Rev Cell Dev Biol 29:529–550
Meeusen S, McCaffery JM, Nunnari J (2004) Mitochondrial fusion intermediates revealed in vitro. Science 305(5691):1747–1752
Mishra VK, Shih HH, Parveen F, Lenzen D, Ito E, Chan TF, Ke LY (2020) Identifying the therapeutic significance of mesenchymal stem cells. Cells 9(5):1145
Missiroli S, Perrone M, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943
Moreira OC, Estebanez B, Martinez-Florez S, de Paz JA, Cuevas MJ, Gonzalez-Gallego J (2017) Mitochondrial function and mitophagy in the elderly: effects of exercise. Oxid Med Cell Longev 2017:2012798
Mudau M, Genis A, Lochner A, Strijdom H (2012) Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc J Afr 23(4):222–231
Munzel T, Daiber A (2015) Redox regulation of dihydrofolate reductase: friend or troublemaker? Arterioscler Thromb Vasc Biol 35(11):2261–2262
Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417(1):1–13
Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93(2):229–240
Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183(5):795–803
Niccoli G, Baca M, De Spirito M, Parasassi T, Cosentino N, Greco G, Conte M, Montone RA, Arcovito G, Crea F (2012) Impact of electronegative low-density lipoprotein on angiographic coronary atherosclerotic burden. Atherosclerosis 223(1):166–170
Nunez MT, Hidalgo C (2019) Noxious iron-calcium connections in neurodegeneration. Front Neurosci 13:48
Nuttall SL, Heaton S, Piper MK, Martin U, Gordon C (2003) Cardiovascular risk in systemic lupus erythematosus–evidence of increased oxidative stress and dyslipidaemia. Rheumatology (oxford) 42(6):758–762
Ogura S, Kakino A, Sato Y, Fujita Y, Iwamoto S, Otsui K, Yoshimoto R, Sawamura T (2009) Lox-1: the multifunctional receptor underlying cardiovascular dysfunction. Circ J 73(11):1993–1999
Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K (2012) Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485(7397):251–255
Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S (2005) Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med 202(10):1333–1339
Okamoto K, Shaw JM (2005) Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu Rev Genet 39:503–536
Olzmann JA, Carvalho P (2019) Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol 20(3):137–155
Osipov RM, Bianchi C, Feng J, Clements RT, Liu Y, Robich MP, Glazer HP, Sodha NR, Sellke FW (2009) Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion. Circulation 120(11 Suppl):S22-30
Pangare M, Makino A (2012) Mitochondrial function in vascular endothelial cell in diabetes. J Smooth Muscle Res 48(1):1–26
Papapanagiotou A, Siasos G, Kassi E, Gargalionis AN, Papavassiliou AG (2015) Novel inflammatory markers in hyperlipidemia: clinical implications. Curr Med Chem 22(23):2727–2743
Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J (2009) Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol 29(4):1007–1016
Parsons MJ, Green DR (2010) Mitochondria in cell death. Essays Biochem 47:99–114
Parthasarathy S, Wieland E, Steinberg D (1989) A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc Natl Acad Sci USA 86(3):1046–1050
Pasceri V, Willerson JT, Yeh ET (2000) Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102(18):2165–2168
Pasceri V, Cheng JS, Willerson JT, Yeh ET (2001) Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation 103(21):2531–2534
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100(14):8466–8471
Peng W, Cai G, Xia Y, Chen J, Wu P, Wang Z, Li G, Wei D (2019) Mitochondrial dysfunction in atherosclerosis. DNA Cell Biol 38(7):597–606
Petan T, Jarc E, Jusovic M (2018) Lipid droplets in cancer: guardians of fat in a stressful world. Molecules 23(8):1941
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350(7):664–671
Petri M, Roubenoff R, Dallal GE, Nadeau MR, Selhub J, Rosenberg IH (1996) Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet 348(9035):1120–1124
Pickrell AM, Youle RJ (2015) The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson’s disease. Neuron 85(2):257–273
Pieper GM (1999) Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 42(2):204–213
Pouwer MG, Pieterman EJ, Worms N, Keijzer N, Jukema JW, Gromada J, Gusarova V, Princen HMG (2020) Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice. J Lipid Res 61(3):365–375
Poznyak AV, Ivanova EA, Sobenin IA, Yet SF, Orekhov AN (2020) The role of mitochondria in cardiovascular diseases. Biology (basel) 9(6):137
Prentki M, Matschinsky FM, Madiraju SR (2013) Metabolic signaling in fuel-induced insulin secretion. Cell Metab 18(2):162–185
Puri R, Nissen SE, Shao M, Elshazly MB, Kataoka Y, Kapadia SR, Tuzcu EM, Nicholls SJ (2016) Non-HDL cholesterol and triglycerides: implications for coronary atheroma progression and clinical events. Arterioscler Thromb Vasc Biol 36(11):2220–2228
Qian S, Huo D, Wang S, Qian Q (2011) Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress. J Ethnopharmacol 137(2):985–991
Quinn MT, Parthasarathy S, Fong LG, Steinberg D (1987) Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 84(9):2995–2998
Raggi P, Genest J, Giles JT, Rayner KJ, Dwivedi G, Beanlands RS, Gupta M (2018) Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions. Atherosclerosis 276:98–108
Ramji DP, Davies TS (2015) Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets. Cytokine Growth Factor Rev 26(6):673–685
Reddy PH (2014) Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction. J Alzheimers Dis 40(2):245–256
Refai TM, Al-Salem IH, Nkansa-Dwamena D, Al-Salem MH (2002) Hyperhomocysteinaemia and risk of thrombosis in systemic lupus erythematosus patients. Clin Rheumatol 21(6):457–461
Reubold TF, Eschenburg S, Becker A, Leonard M, Schmid SL, Vallee RB, Kull FJ, Manstein DJ (2005) Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A 102(37):13093–13098
Rhew EY, Ramsey-Goldman R (2006) Premature atherosclerotic disease in systemic lupus erythematosus–role of inflammatory mechanisms. Autoimmun Rev 5(2):101–105
Rhoads JP, Major AS (2018) How oxidized low-density lipoprotein activates inflammatory responses. Crit Rev Immunol 38(4):333–342
Riccioni G, Zanasi A, Vitulano N, Mancini B, D’Orazio N (2009) Leukotrienes in atherosclerosis: new target insights and future therapy perspectives. Mediators Inflamm 2009:737282
Roman MJ, Shanker BA, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE (2003) Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus. N Engl J Med 349(25):2399–2406
Rosenson RS, Brewer HB Jr, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR (2016) Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol 13(1):48–60
Ross R (1999a) Atherosclerosis–an inflammatory disease. N Engl J Med 340(2):115–126
Ross R (1999b) Atherosclerosis is an inflammatory disease. Am Heart J 138(5 Pt 2):S419-420
Ruiz-Limon P, Barbarroja N, Perez-Sanchez C, Aguirre MA, Bertolaccini ML, Khamashta MA, Rodriguez-Ariza A, Almaden Y, Segui P, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Collantes-Estevez E, Cuadrado MJ, Lopez-Pedrera C (2015) Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment. Ann Rheum Dis 74(7):1450–1458
Saez-Atienzar S, Bonet-Ponce L, Blesa JR, Romero FJ, Murphy MP, Jordan J, Galindo MF (2014) The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis 5:e1368
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456(7219):264–268
Salabei JK, Hill BG (2013) Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation. Redox Biol 1:542–551
Sanchez-Quesada JL, Perez A, Caixas A, Ordonmez-Llanos J, Carreras G, Payes A, Gonzalez-Sastre F, de Leiva A (1996) Electronegative low density lipoprotein subform is increased in patients with short-duration IDDM and is closely related to glycaemic control. Diabetologia 39(12):1469–1476
Sanchez-Quesada JL, Perez A, Caixas A, Rigla M, Payes A, Benitez S, Ordonez-Llanos J (2001) Effect of glycemic optimization on electronegative low-density lipoprotein in diabetes: relation to nonenzymatic glycosylation and oxidative modification. J Clin Endocrinol Metab 86(7):3243–3249
Sanchez-Quesada JL, Benitez S, Otal C, Franco M, Blanco-Vaca F, Ordonez-Llanos J (2002) Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects. J Lipid Res 43(5):699–705
Sanda GM, Stancu CS, Deleanu M, Toma L, Niculescu LS, Sima AV (2021) Aggregated LDL turn human macrophages into foam cells and induce mitochondrial dysfunction without triggering oxidative or endoplasmic reticulum stress. PLoS ONE 16(1):e0245797
Santel A, Fuller MT (2001) Control of mitochondrial morphology by a human mitofusin. J Cell Sci 114(Pt 5):867–874
Satoh M, Takahashi Y, Tabuchi T, Minami Y, Tamada M, Takahashi K, Itoh T, Morino Y, Nakamura M (2015) Cellular and molecular mechanisms of statins: an update on pleiotropic effects. Clin Sci (lond) 129(2):93–105
Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386(6620):73–77
Scheffler IE (2001) Mitochondria make a come back. Adv Drug Deliv Rev 49(1–2):3–26
Schwandt P, Liepold E, Bertsch T, Haas GM (2010) Lifestyle, cardiovascular drugs and risk factors in younger and elder adults: the PEP family heart study. Int J Prev Med 1(1):56–61
Seifert PS, Kazatchkine MD (1988) The complement system in atherosclerosis. Atherosclerosis 73(2–3):91–104
Shapiro MD, Fazio S (2017) PCSK9 and atherosclerosis - lipids and beyond. J Atheroscler Thromb 24(5):462–472
Sharma N, Okere IC, Brunengraber DZ, McElfresh TA, King KL, Sterk JP, Huang H, Chandler MP, Stanley WC (2005) Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation. J Physiol 562(Pt 2):593–603
Shemiakova T, Ivanova E, Grechko AV, Gerasimova EV, Sobenin IA, Orekhov AN (2020) Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis. Biomedicines 8(6):166
Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A (2014) Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1beta in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol 192(5):2029–2033
Sheridan C, Martin SJ (2010) Mitochondrial fission/fusion dynamics and apoptosis. Mitochondrion 10(6):640–648
Shibu MA, Lin YJ, Chiang CY, Lu CY, Goswami D, Sundhar N, Agarwal S, Islam MN, Lin PY, Lin SZ, Ho TJ, Tsai WT, Kuo WW, Huang CY (2022) Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders. Biomed Pharmacother 146:112427
Siasos G, Tsigkou V, Kosmopoulos M, Theodosiadis D, Simantiris S, Tagkou NM, Tsimpiktsioglou A, Stampouloglou PK, Oikonomou E, Mourouzis K, Philippou A, Vavuranakis M, Stefanadis C, Tousoulis D, Papavassiliou AG (2018) Mitochondria and cardiovascular diseases-from pathophysiology to treatment. Ann Transl Med 6(12):256
Simoneau JA, Kelley DE (1997) Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol 83(1):166–171
Skaggs BJ, Hahn BH, McMahon M (2012) Accelerated atherosclerosis in patients with SLE–mechanisms and management. Nat Rev Rheumatol 8(4):214–223
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ (2018) Parkin and PINK1 mitigate STING-induced inflammation. Nature 561(7722):258–262
Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR (2005) A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54(7):1926–1933
Springer MZ, Macleod KF (2016) In brief: mitophagy: mechanisms and role in human disease. J Pathol 240(3):253–255
Sproston NR, Ashworth JJ (2018) Role of C-reactive protein at sites of inflammation and infection. Front Immunol 9:754
Staehr P, Hother-Nielsen O, Landau BR, Chandramouli V, Holst JJ, Beck-Nielsen H (2003) Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis. Diabetes 52(2):260–267
Stalenhoef AF, van’t Laar A (1986) Clinical significance of current perspectives in cholesterol metabolism. Ned Tijdschr Geneeskd 130(21):951–955
Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH (2016) Interplay between CRP, Atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem 62(2):320–327
Stannard AK, Riddell DR, Sacre SM, Tagalakis AD, Langer C, von Eckardstein A, Cullen P, Athanasopoulos T, Dickson G, Owen JS (2001) Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. J Biol Chem 276(49):46011–46016
Steinberg D (1997) Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 272(34):20963–20966
Steinberg D (2002) Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 8(11):1211–1217
Steinberg D (2009) The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 50(Suppl):S376-381
Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, Bayazeed B, Baron AD (1997) Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100(5):1230–1239
Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (2004) Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci 117(Pt 7):1201–1210
Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, Eddleman KM, Jarrett NM, LaBresh K, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF, American College of Cardiology/American Heart Association Task Force on Practice, G (2014) 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 129(25 Suppl 2):S1-45
Suarez-Rivero JM, Villanueva-Paz M, de la Cruz-Ojeda P, de la Mata M, Cotan D, Oropesa-Avila M, de Lavera I, Alvarez-Cordoba M, Luzon-Hidalgo R, Sanchez-Alcazar JA (2016) Mitochondrial dynamics in mitochondrial diseases. Diseases 5(1):5
Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y (2009) LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res 84(1):127–136
Tabas I, Bornfeldt KE (2016) Macrophage phenotype and function in different stages of atherosclerosis. Circ Res 118(4):653–667
Tahrir FG, Langford D, Amini S, Mohseni Ahooyi T, Khalili K (2019) Mitochondrial quality control in cardiac cells: mechanisms and role in cardiac cell injury and disease. J Cell Physiol 234(6):8122–8133
Talukder MA, Yang F, Nishijima Y, Chen CA, Kalyanasundaram A, Periasamy M, Zweier JL (2009) Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery. J Mol Cell Cardiol 46(2):285–287
Tan KT, Watson SP, Lip GY (2004) The endothelium and platelets in cardiovascular disease: potential targets for therapeutic intervention. Curr Med Chem Cardiovasc Hematol Agents 2(2):169–178
Tang X, Luo YX, Chen HZ, Liu DP (2014) Mitochondria, endothelial cell function, and vascular diseases. Front Physiol 5:175
Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G, Gissi HFI (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372(9645):1223–1230
Taylor RW, Turnbull DM (2005) Mitochondrial DNA mutations in human disease. Nat Rev Genet 6(5):389–402
Taylor F, Ward K, Moore TH, Burke M, Davey Smith G, Casas JP, Ebrahim S (2011) Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 1:CD004816
Tedesco F, Fischetti F, Pausa M, Dobrina A, Sim RB, Daha MR (1999) Complement-endothelial cell interactions: pathophysiological implications. Mol Immunol 36(4–5):261–268
Tedesco F, Fischetti F, Pausa M, Dobrina A, Sim RB, Daha MR (2000) Complement-endothelial cell interactions: pathophysiological implications. Mol Immunol 37(1–2):91
Tedgui A, Mallat Z (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 86(2):515–581
Terman A, Brunk UT (2004) Myocyte aging and mitochondrial turnover. Exp Gerontol 39(5):701–705
Tilokani L, Nagashima S, Paupe V, Prudent J (2018) Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem 62(3):341–360
Tousoulis D, Oikonomou E, Economou EK, Crea F, Kaski JC (2016) Inflammatory cytokines in atherosclerosis: current therapeutic approaches. Eur Heart J 37(22):1723–1732
Touyz RM, Montezano AC (2012) Vascular Nox4: a multifarious NADPH oxidase. Circ Res 110(9):1159–1161
Tsokos GC, Fleming SD (2004) Autoimmunity, complement activation, tissue injury and reciprocal effects. Curr Dir Autoimmun 7:149–164
Tuttolomondo A (2012) Editorial: treatment of atherosclerosis as an inflammatory disease. Curr Pharm Des 18(28):4265
Umezu R, Koga JI, Matoba T, Katsuki S, Wang L, Hasuzawa N, Nomura M, Tsutsui H, Egashira K (2020) Macrophage (Drp1) dynamin-related protein 1 accelerates intimal thickening after vascular injury. Arterioscler Thromb Vasc Biol 40(7):e214–e226
Valanti EK, Dalakoura-Karagkouni K, Sanoudou D (2018) Current and emerging reconstituted HDL-apoA-I and HDL-apoE approaches to treat atherosclerosis. J Pers Med 8(4):34
van der Bliek AM, Shen Q, Kawajiri S (2013) Mechanisms of mitochondrial fission and fusion. Cold Spring Harb Perspect Biol 5(6):a011072
van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL (2012) Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36(1):68–78
van Opbergen CJM, den Braven L, Delmar M, van Veen TAB (2019) Mitochondrial dysfunction as substrate for arrhythmogenic cardiomyopathy: a search for new disease mechanisms. Front Physiol 10:1496
Violi F, Carnevale R, Loffredo L, Pignatelli P, Gallin JI (2017) NADPH oxidase-2 and atherothrombosis: insight from chronic granulomatous disease. Arterioscler Thromb Vasc Biol 37(2):218–225
Vita JA, Keaney JF Jr (2002) Endothelial function: a barometer for cardiovascular risk? Circulation 106(6):640–642
von Muhlinen N, Thurston T, Ryzhakov G, Bloor S, Randow F (2010) NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria. Autophagy 6(2):288–289
Vyas S, Zaganjor E, Haigis MC (2016) Mitochondria and cancer. Cell 166(3):555–566
Wadhera RK, Steen DL, Khan I, Giugliano RP, Foody JM (2016) A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. J Clin Lipidol 10(3):472–489
Wang K, Klionsky DJ (2011) Mitochondria removal by autophagy. Autophagy 7(3):297–300
Wang C, Youle RJ (2009) The role of mitochondria in apoptosis*. Annu Rev Genet 43:95–118
Welte MA, Gould AP (2017) Lipid droplet functions beyond energy storage. Biochim Biophys Acta Mol Cell Biol Lipids 1862(10 Pt B):1260–1272
Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC (2015) CHOP links endoplasmic reticulum stress to NF-kappaB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell 26(12):2190–2204
Witztum JL, Steinberg D (2001) The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc Med 11(3–4):93–102
Wu D, Sharan C, Yang H, Goodwin JS, Zhou L, Grabowski GA, Du H, Guo Z (2007) Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res 48(12):2571–2578
Wurzel J, Goldman BI (2004) Premature coronary disease in systemic lupus. N Engl J Med 350(15):1571–1575 (author reply 1571-1575)
Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Munzel T, Daiber A, Forstermann U, Li H (2016) Uncoupling of endothelial nitric oxide synthase in perivascular adipose tissue of diet-induced obese mice. Arterioscler Thromb Vasc Biol 36(1):78–85
Xie Z, Zhang J, Wu J, Viollet B, Zou MH (2008) Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. Diabetes 57(12):3222–3230
Xie LL, Shi F, Tan Z, Li Y, Bode AM, Cao Y (2018) Mitochondrial network structure homeostasis and cell death. Cancer Sci 109(12):3686–3694
Xu X, Zhang A, Li N, Li PL, Zhang F (2015) Concentration-dependent diversifcation effects of free cholesterol loading on macrophage viability and polarization. Cell Physiol Biochem 37(2):419–431
Yang Z, Ming XF (2006) Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin Med Res 4(1):53–65
Yang CY, Raya JL, Chen HH, Chen CH, Abe Y, Pownall HJ, Taylor AA, Smith CV (2003) Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arterioscler Thromb Vasc Biol 23(6):1083–1090
Yasue H, Hirai N, Mizuno Y, Harada E, Itoh T, Yoshimura M, Kugiyama K, Ogawa H (2006) Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokers. Circ J 70(1):8–13
Yau JW, Teoh H, Verma S (2015) Endothelial cell control of thrombosis. BMC Cardiovasc Disord 15:130
Ylikallio E, Suomalainen A (2012) Mechanisms of mitochondrial diseases. Ann Med 44(1):41–59
Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003) The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 23(15):5409–5420
Yoshida H, Quehenberger O, Kondratenko N, Green S, Steinberg D (1998) Minimally oxidized low-density lipoprotein increases expression of scavenger receptor A, CD36, and macrosialin in resident mouse peritoneal macrophages. Arterioscler Thromb Vasc Biol 18(5):794–802
Yoshida H, Ishikawa T, Hosoai H, Suzukawa M, Ayaori M, Hisada T, Sawada S, Yonemura A, Higashi K, Ito T, Nakajima K, Yamashita T, Tomiyasu K, Nishiwaki M, Ohsuzu F, Nakamura H (1999) Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem Pharmacol 58(11):1695–1703
Yoshida H, Sasaki K, Namiki Y, Sato N, Tada N (2005) Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase. Atherosclerosis 179(1):97–102
Yu EP, Bennett MR (2014) Mitochondrial DNA damage and atherosclerosis. Trends Endocrinol Metab 25(9):481–487
Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR (2013) Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation 128(7):702–712
Yuan Hsieh DJ, Islam MN, Kuo WW, Shibu MA, Lai CH, Lin PY, Lin SZ, Chen MY, Huang CY (2023) A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho-1 signaling pathways in SD rats with doxorubicin-induced acute cardiotoxicity. Environ Toxicol 38(12):3026–3042
Yue L, Bian JT, Grizelj I, Cavka A, Phillips SA, Makino A, Mazzone T (2012) Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase. Hypertension 60(4):1040–1046
Zeleny M, Swertfeger DK, Weisgraber KH, Hui DY (2002) Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry 41(39):11820–11823
Zha X, Yue Y, Dong N, Xiong S (2015) Endoplasmic reticulum stress aggravates viral myocarditis by raising inflammation through the IRE1-associated NF-kappaB pathway. Can J Cardiol 31(8):1032–1040
Zhang M, Deng Q, Wang L, Huang Z, Zhou M, Li Y, Zhao Z, Zhang Y, Wang L (2018) Prevalence of dyslipidemia and achievement of low-density lipoprotein cholesterol targets in Chinese adults: A nationally representative survey of 163,641 adults. Int J Cardiol 260:196–203
Zhao H, Luo Y, Chen L, Zhang Z, Shen C, Li Y, Xu R (2018) Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/beta-catenin pathway and blocking mitochondrial fission. Cell Stress Chaperones 23(5):1079–1092
Zheng J, Lu C (2020) Oxidized LDL causes endothelial apoptosis by inhibiting mitochondrial fusion and mitochondria autophagy. Front Cell Dev Biol 8:600950
Zheng Z, Chen H, Zhao H, Liu K, Luo D, Chen Y, Chen Y, Yang X, Gu Q, Xu X (2010) Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro. Invest Ophthalmol vis Sci 51(1):64–71
Zhou H, Du W, Li Y, Shi C, Hu N, Ma S, Wang W, Ren J (2018a) Effects of melatonin on fatty liver disease: the role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy. J Pineal Res. https://doi.org/10.1111/jpi.12450
Zhou H, Shi C, Hu S, Zhu H, Ren J, Chen Y (2018b) BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways. Angiogenesis 21(3):599–615
Zhu L, Chen Z, Han K, Zhao Y, Li Y, Li D, Wang X, Li X, Sun S, Lin F, Zhao G (2020) Correlation between mitochondrial dysfunction, cardiovascular diseases, and traditional Chinese medicine. Evid Based Complement Alternat Med 2020:2902136
Ziouzenkova O, Asatryan L, Sahady D, Orasanu G, Perrey S, Cutak B, Hassell T, Akiyama TE, Berger JP, Sevanian A, Plutzky J (2003) Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. J Biol Chem 278(41):39874–39881
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We want to give thanks our Tzu Chi University, Microbiology and Immunology department, Tzu Chi Hospital, Taiwan and Kaohsiung Medical University regarding contribution giving some idea when writing manuscript.
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This review study was supported by the Ministry of Science and Technology, Taiwan. Funding number is MOST 111-2314-B-303-008-MY3.
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Conceptualization, V.K.M; formal analysis, V.K.M, M.N.I, R.M, S.F.A, K.A; investigation, V.K.M, M.N.I, C.Y.H; writing—original draft preparation, V.K.M, M.NI, F.P, R.M, S.F.A, K.A; writing—review and editing, V.K.M, M.N.I. T.A,T.J.H; supervision, V.K.M & M.N.I.; All authors have read and agreed to the published version of the manuscript.
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Islam, M.N., Mishra, V.K., Munalisa, R. et al. Mechanistic insight of mitochondrial dysfunctions in cardiovascular diseases with potential biomarkers. Mol. Cell. Toxicol. (2024). https://doi.org/10.1007/s13273-023-00424-4
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DOI: https://doi.org/10.1007/s13273-023-00424-4