We have developed the capability to elucidate interfacial reaction dynamics using an arguably unique combination of supersonic molecular beams combined with in situ STM visualization. These capabilities have been implemented in order to reveal the complex spatiotemporal correlations that govern the oxidation of graphitic systems spanning atomic-, nano-, and meso-length scales. In this study, the 3 nm periodic moiré pattern of monolayer and bilayer graphene on Ru(0001) provides a diverse palette of potential scattering and binding sites at the interface for ground state atomic oxygen. We resolve the site-specificity of atomic oxygen placement on the moiré lattice for both monolayer and bilayer graphene on Ru(0001) with atomic resolution. Angle- and energy-controlled scattering of O(3P) on these interfaces reveals an incisive side-by-side comparison of preferential reactivity of the monolayer surface compared to a more free-standing bilayer graphene ruthenium interface. Morphologically dependent reactivity of many layered graphene (HOPG) and monolayer graphene on Ru(0001) reveal anisotropic on-surface reactivity dependent on the presence of proximal reacted sites or local regions. The kinetics of on-surface oxidation are additionally shown to influence the morphology of surface products by varying the temperature of the interface and flux of reactant species. Such correlations are important in chemisorption, catalysis, materials oxidation and erosion, and film processing—and tunable moiré templated adsorption is a route to well-ordered self-assembled 2D materials for use in next-generation platforms for quantum devices and catalysis. Taken together, these results highlight a new direction in the examination of interfacial reaction dynamics where incident beam kinetic energy and angle of incidence can be used for reaction control parameters with outcomes such as site-specific reactivity, changes for overall time-evolving mechanisms, and the relative importance of non-adiabatic channels in adsorption all linked to the on-surface fate of chemisorbed species.