The chemoresistant and immunoevasive characteristics of leukaemia stem cells (LSCs) impede the treatment efficacy for acute myeloid leukaemia (AML). We find that inhibiting the tyrosine phosphatase SHP-1 effectively alters the metabolic state of LSCs, making them more susceptible to chemotherapy and immune surveillance in AML.
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References
Hope, K. J., Jin, L. & Dick, J. E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 5, 738–743 (2004). This paper reports the heterogeneity of LSCs.
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Jiang, L. et al. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-beta signaling. J. Exp. Med. 215, 1337–1347 (2018). This paper reports the role of SHP-1 in haematopoietic stem cells.
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This is a summary of: Xu, X. et al. SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01349-3 (2024).
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Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1. Nat Cell Biol 26, 329–330 (2024). https://doi.org/10.1038/s41556-024-01350-w
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DOI: https://doi.org/10.1038/s41556-024-01350-w
