Abstract
Background
Behcet’s disease (BD) is a multisystem autoimmune relapsing vasculitis with an almost unknown etiology involving both large and small vessels. The neurological involvement called neuro-Behcet’s disease (NBD) is rare. NBD can be responsible for tumor-like masses mimicking low-grade gliomas in only a few cases.
Methods
We report here the main characteristics, treatment, and outcome of 43 patients (4 personal cases and 39 patients from the literature) with a pseudotumoral presentation of NBD (PT NBD). We compared our findings with those of the classical form of NBD.
Results
The median age was 35.86 (12–59 years) years, with a male predominance (67.4%). PT NBD was the inaugural of the disease in 51.2% of cases. The neurological manifestations included headache (n = 31), pyramidal syndrome (n = 28), cerebellar syndrome (n = 5), behavioral changes (n = 5), and pseudobulbar signs (n = 2). Ophthalmologic examination revealed papilledema in 3 cases. On cerebral imaging, the most affected regions of the brain were the capsulothalamic region (n = 15, 37.5%) and the brainstem (n = 14, 35). Histological analysis revealed necrotic lesions with perivascular inflammatory infiltrate without signs of tumoral or infectious lesions. Treatment consisted of corticosteroids (n = 40, 93%) and immunosuppressive agents (n = 28, 65.11%), leading to complete clinical and imaging remission in 41.5% of patients.
Conclusion
PT NBD is a rare but life-threatening condition.
Similar content being viewed by others
References
Rodríguez-Carrio J, Nucera V, Masala IF, Atzeni F (2021) Behçet disease: from pathogenesis to novel therapeutic options. Pharmacol Res Mai 167:105593
Borhani-Haghighi A, Kardeh B, Banerjee S, Yadollahikhales G, Safari A, Sahraian MA et al (2019) Neuro-Behcet’s disease: an update on diagnosis, differential diagnoses, and treatment. Mult Scler Relat Disord 39:101906
Sarac ME, Oktay K, Guzel E, Mammadov M, Sari I, Guzel A (2021) Neuro-behçet’s disease mimicking low-grade Glioma presenting with drop foot. Neurol India 69(5):1427–1429
Bennett DLH, McCabe DJH, Stevens JM, Mifsud V, Kitchen ND, Giovannoni G (2004) Tumefactive neuro-Behcet disease. Neurology 63(4):709
Kır S (2018) Ptosis and mass like lesions in behçet’s disease: a rare presentation. Arch Rheumatol 33(2):221–224
Tsalta-Mladenov ME, Georgieva DK, Andonova SP (2020) Neuro-Behcet´s disease—case report and review. Acta Reumatol Port 45(2):137–142
Zhang L, Wang X, Liu F, Zhang Z (2021) Neuro-Behcet disease. Arch Med Sci AMS 17(2):569–573
Mousa A, Okasha M, Isaacs J, Price D, Bhatnagar P, Joshi A et al (2019) Brain pseudotumour secondary to Behçet’s disease. Ann R Coll Surg Engl 101(8):e164–e168
Guini M et al (2019) Une forme pseudo-tumorale du neuro-Behçet: à propos d’un cas et revue de la littérature. Pan African Medl J 33:194. https://doi.org/10.11604/pamj.2019.33.194.18719
Noel N, Hutie M, Wechsler B, Vignes S, Le Thi H-BD, Amoura Z et al (2012) Pseudotumoural presentation of neuro-Behcet’s disease: case series and review of literature. Rheumatology 51(7):1216–1225
Kalra S, Silman A, Akman-Demir G, Bohlega S, Borhani-Haghighi A, Constantinescu CS et al (2014) Diagnosis and management of Neuro-Behçet’s disease: international consensus recommendations. J Neurol sept 261(9):1662–1676
Ghribi M et al (2020) Une maladie de Behçet révélée par une atteinte neurologique pseudotumorale. PAMJ Clin Med 3:191. https://doi.org/10.11604/pamj-cm.2020.3.191.24400
Noel N, Bernard R, Wechsler B, Resche-Rigon M, Depaz R, Boutin Le DTH et al (2014) Long-term outcome of neuro-Behçet’s disease. Arthritis Rheumatol Hoboken NJ Mai 66(5):1306–1314
Bozca BC, Alpsoy E (2021) Experimental therapeutic solutions for Behcet’s disease. J Exp Pharmacol 13:127–145
Litvan I, Roig C, Rovira A, Ruscalleda J (1987) Behçet’s syndrome masquerading as tumor. Neuroradiology 29(1):103
Kermode AG, Plant GT, MacManus DG, Kendall BE, Kingsley DP, Moseley IF (1989) Behçet’s disease with slowly enlarging midbrain mass on MRI: resolution following steroid therapy. Neurology 39(9):1251–1252
Neudorfer M, Feiler-Ofri V, Geyer O, Reider I (1993) Behçet’s disease presenting as a cerebral tumour. Neuroradiology 35(2):145
Geny C, Cesaro P, Heran F, Nguyen JP, Poirier J, Degos JD (1993) Pseudotumoral neuro-Behçet’s disease. Surg Neurol mai 39(5):374–376
Dupin M, Zimmermann R, Flocard F, Guennoc B, Antoniotti O, Flechaire A et al (1996) Neuro-Behçet disease with solitary cerebral pseudotumor disclosed by headaches. Ann Med Interne 147(7):524–526
Yoshimura J, Toyama M, Sekihara Y, Tamatani S, Nagai H, Fujita S et al (2001) Neuro-Behcet disease mimicking a thalamic tumor. No Shinkei Geka 29(6):527–531
Imoto H, Nishizaki T, Nogami K, Sakamoto K, Nomura S, Akimura T et al (2002) Neuro-Behçet’s disease manifesting as a neoplasm-like lesion–case report. Neurol Med Chir 42(9):406–409
Ben Taarit C, Turki S, Ben MH (2002) Pseudotumoral neurobehçet: a case report. J Mal Vasc Avr 27(2):93–95
Park JH, Jung MK, Bang CO, Park HK, Sung KB, Ahn MY et al (2002) Neuro-Behçet’s disease mimicking a cerebral tumor: a case report. J Korean Med Sci 17(5):718–722
Tuzgen S, Kaya AH, Erdincler D, Oguzoglu SA, Ulu O, Saip S (2003) Two cases of neuro-Behcet’s disease mimicking cerebral tumor. Neurol India 51(3):376–378
Schmolck H (2005) Large thalamic mass due to neuro-Behcet disease. Neurology 65(3):436
Matsuo K, Yamada K, Nakajima K, Nakagawa M (2005) Neuro-Behçet disease mimicking brain tumor. AJNR Am J Neuroradiol 26(3):650–653
Appenzeller S, de Castro R, de Queiroz SL, Madegan L, Soledade C, de Zanardi VA et al (2006) Brain tumor-like lesion in Behçet disease. Rheumatol Int 26(6):577–580
Darmoul M, Habib Bouhaouala M, Smida H, Hedi DM (2006) Pseudo-tumoral neuro-Behçet’s disease. Rev Neurol 162(5):643–647
Heo JH, Lee ST, Chu K, Kim M (2008) Neuro-Behcet’s disease mimicking multiple brain tumors: diffusion-weighted MR study and literature review. J Neurol Sci 264(1–2):177–181
Varoglu AO (2010) A case of Neuro-Behcet disease mimicking gliomatosis cerebri. AJNR Am J Neuroradiol 31(1):E1
Bouomrani S, Hammami S, Braham R, Mahjoub S (2010) Ciclosporin-associated cerebral tumor-like location of Behçet’s disease. Rev Neurol 166(10):849–854
Shapiro LS, Farrell J, Borhani HA (2012) Tocilizumab treatment for neuro-Behcet’s disease, the first report. Clin Neurol Neurosurg 114(3):297–298
Bilge NŞY, Şaylısoy S, Kaşifoglu T, Korkmaz C (2014) Mass-like lesions as a rare form of neuro-Behçet’s disease: a case report and review of the literature. Eur J Rheumatol 1(1):34–38
Martínez-Estupiñán L, López-Longo FJ, Monteagudo I, Carreño PL (2015) Pseudotumoral neurobehçet in a patient treated with anti-tumor necrosis factor alpha. Med Clin 144(5):235–236
Alfedaghi AS, Masters Y, Mourou M, Eshak O (2015) A brain mass in a patient with Behcet’s disease: a case report. J Med Case Reports 9(1):209
Jade J, Chung K, Arendse M, Hussain Z, White D (2016) Neuro-Behçet’s disease presenting with tumour-like lesions and responding to rituximab. J Clin Neurosci 32:139–141
Acknowledgements
Not applicable
Funding
Not applicable.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval and consent to participate
This study was approved by the ethical committee of our hospital Fattouma Bourguiba Monastir, Tunisia.
Conflict of interest
The authors declare that they have no conflicts of interest concerning this article.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Hadj Taieb, M., Slimane, H., Mhiri, M. et al. Pseudotumoral neuro-behcet’s disease: case series and review of literature. Acta Neurol Belg 124, 431–445 (2024). https://doi.org/10.1007/s13760-024-02477-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13760-024-02477-1