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Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia

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Abstract

The term “juvenile-like (inflammatory/hyperplastic) mucosal polyps” (JLIHMP) has been recently introduced to describe a spectrum of polypoid lesions in patients with neurofibromatosis type 1 (NF-1). Due to the scarce number of reported cases and histopathological similarities with entities such as sporadic/syndromic juvenile polyps or inflammatory fibroid polyps, this entity remains a subject of debate. We describe herein a case of multiple JLIHMPs in a patient with NF-1, and we document the presence of low-grade dysplasia within one of these polyps.

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References

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Authors and Affiliations

  1. Department of Pathology, Saint-Antoine Hospital, AP-HP, Sorbonne Université, Paris, France

    Diana Enea, Matthieu Yver, Pascale Cervera & Magali Svrcek

  2. Centre for Digestive Endoscopy, Saint-Antoine Hospital, AP-HP, Sorbonne Université, Paris, France

    Xavier Dray & Antoine Guilloux

  3. Department of Genetics, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France

    Erell Guillerm

Authors
  1. Diana Enea
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  2. Xavier Dray
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  3. Erell Guillerm
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  4. Antoine Guilloux
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  5. Matthieu Yver
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  6. Pascale Cervera
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  7. Magali Svrcek
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Contributions

DE, XD, and MS conducted the literature research and participated in writing and revision of the manuscript. XD and AG provided clinical information and endoscopic images. MS contributed in establishing the pathological diagnosis and providing microscopic images. MY provided histopathological images. EG and PC performed the molecular analysis. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Diana Enea.

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The authors declare no competing interests.

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Enea, D., Dray, X., Guillerm, E. et al. Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia. Virchows Arch (2024). https://doi.org/10.1007/s00428-024-03769-w

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  • DOI: https://doi.org/10.1007/s00428-024-03769-w

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