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Invasive disease caused simultaneously by two different serotypes of Streptococcus pneumoniae: a microbiological appreciation

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Abstract

We report a clinical case of a child with an invasive pneumococcal disease caused by two different pneumococcal serotypes that belonged to different sequence types. She was a 15-month-old girl with pneumonia and pleural effusion in which S. pneumoniae colonies with different morphologies grew, one from the blood culture (characteristic greyish appearance) and the other from the pleural fluid (mucoid appearance). The isolate from blood was serotype 22 F (ST698/CC698/GPSC61), while the isolate from the pleural fluid was serotype 3 (ST180/CC180/GPSC12). The patient fully recovered after treatment with intravenous ampicillin followed by oral amoxicillin.

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All data that support the findings of this study are presented in the manuscript.

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Acknowledgements

To the members of the Paediatric services who cared for the patient.

Funding

This project was partially funded by Ministerio de Ciencia e Innovación (MICINN) [grant PID2020-119298RB-I00].

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Authors and Affiliations

  1. Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain

    Emilia Cercenado

  2. CIBER of Respiratory Diseases (CIBERES), Madrid, 28029, Spain

    Emilia Cercenado, Julio Sempere & Jose Yuste

  3. Clinical Microbiology Unit, Public Health Regional Laboratory of the Community of Madrid, Directorate General of Public Health, Regional Ministry of Health of Madrid, Madrid, 28055, Spain

    Belén Ramos, Marta Pérez-Abeledo & Juan Carlos Sanz

  4. Spanish Pneumococcal Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain

    Julio Sempere & Jose Yuste

  5. CIBER of Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain

    Juan Carlos Sanz

Authors
  1. Emilia Cercenado
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  2. Belén Ramos
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  3. Marta Pérez-Abeledo
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  4. Julio Sempere
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  5. Jose Yuste
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  6. Juan Carlos Sanz
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Contributions

All authors participated in the conceptualization, methodology, preparation of the first and final drafts, final review, and editing.

Corresponding author

Correspondence to Juan Carlos Sanz.

Ethics declarations

Ethics approval

Not applicable. This report describes a microbiological appreciation during a routine laboratory testing.

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Not applicable. The findings reported in this study are the result of routine laboratory testing.

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Not applicable. This report describes a microbiological appreciation during a routine laboratory testing.

Conflicts of interest/Competing interests

The authors declare no conflict of interest related to this work. This case was presented in part at the 33th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Copenhagen (Denmark). April 2023.

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Cercenado, E., Ramos, B., Pérez-Abeledo, M. et al. Invasive disease caused simultaneously by two different serotypes of Streptococcus pneumoniae: a microbiological appreciation. Eur J Clin Microbiol Infect Dis (2024). https://doi.org/10.1007/s10096-024-04787-x

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