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An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing

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Abstract

Introduction

High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).

Objectives

In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.

Methods

Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.

Results

The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.

Conclusion

The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.

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Funding

This research was funded by the Natural Science Foundation Innovation and Development Joint Fund Project of Chongqing (2023NSCQ-LZX0187) and the Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0712).

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Author notes

  1. Zeng Liu and Chunling Liu contributed equally to this work.

Authors and Affiliations

  1. Chongqing Key Laboratory of Industrial Fermentation Microorganisms, College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, 401331, China

    Zeng Liu, Renyu Fan, Yuting Wang, Linxiu Luo, Yanling Jiang, Jincao Tang, Zheng Lu, Libo Chen, Shuangkou Chen, Tianbing Guan & Chuanyun Dai

  2. Chongqing Public Health Medical Center, Chongqing, 400036, China

    Chunling Liu

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  1. Zeng Liu
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Correspondence to Tianbing Guan.

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Liu, Z., Liu, C., Fan, R. et al. An Understanding of the Relationship Between Mixing Performance and Power Consumption in a High-Shear Wet Granulation Pre-mixing. J Pharm Innov 19, 10 (2024). https://doi.org/10.1007/s12247-024-09816-y

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