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Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders

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Abstract

Neuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain–Barré syndrome, are characterized by the dysfunction of both the immune system and the nervous system. Increasing evidence suggests that extracellular vesicles and autophagy are closely associated with the pathogenesis of these disorders. In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications. Here we highlight the need for further research to fully understand the mechanisms underlying these disorders, and to develop new diagnostic and therapeutic strategies.

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Acknowledgements

This review was supported by the National Key Research and Development Project of Stem Cell and Translational Research by the Ministry of Science and Technology (2020YFA0113100), Innovative Research Team of High-Level Local Universities in Shanghai (SHSMU-ZDCX20211901), the National Natural Science Foundation of China (82071341), and the Key Projects of Basic Research of Shanghai Municipal Science and Technology Commission (20JC1412000).

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  1. Xiwen Ai and Haojun Yu contributed equally to this review.

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  1. Department of Neurology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, 200127, China

    Xiwen Ai, Haojun Yu & Yangtai Guan

  2. Department of Neurology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA

    Yu Cai

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Ai, X., Yu, H., Cai, Y. et al. Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01183-5

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