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Histopathological analysis of the wall enhancement of the spinal dural arteriovenous fistulae’s draining veins

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Abstract

Objective

The mechanism behind SDAVF is still unclear. We discovered that the vessel wall of the SDAVF-DV occasionally showed enhancement in MRI, and this study assessed the relationship between the enhancement of the draining vein’s wall and its histology.

Methods

For histopathologic analysis, 16 draining vein samples from 16 patients with SDAVF were included, 3 normal arteries and 3 normal veins were chosen as comparison. We assessed the imaging and microscopic characteristics of the draining veins in SDAVF patients. The former included the presence of significant enhancement of the wall of the draining vein in MRI, and the latter included the adherence, aggregation, infiltration of pro-inflammatory factors and inflammatory cells. Immuno-histochemical staining was performed using IL-1β, IL-8, TGF-β as well as MPO and MMP-9, and positive results were counted. Multiple logistic regression analysis was used to determine whether the infiltration of inflammatory cells was connected to vessel wall enhancement in the SDAVF-DV.

Results

Infiltration of inflammatory cells was significantly higher in SDAVF-DV compared to normal vessels, 7 out of 16 patients significantly had enhancement of the vessel wall of SDAVF-DV, and logistic regression analysis showed that samples with more infiltration of inflammatory cells were more likely to show enhancement of the SDAVF-DV walls.

Conclusion

There was considerable inflammatory cells infiltration in SDAVF-DV, and this may explain why their vessel wall had such a significant enhancement in MRI.

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Availability of data and materials

The datasets generated or analyzed during the study are included in this published article and its supplement.

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Authors and Affiliations

  1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China

    Xiaojun Hu, Yuhang Diao, Zhenghao Hao, Mingyu Hao, Minghao Xie, Hongtao Rong & Tao Zhu

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  1. Xiaojun Hu
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  2. Yuhang Diao
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  3. Zhenghao Hao
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  4. Mingyu Hao
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  5. Minghao Xie
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  6. Hongtao Rong
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  7. Tao Zhu
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Contributions

XH: writing—original draft editing. YD, MH, MX: writing—review & editing. HR: conceptualization. TZ: supervision.

Corresponding author

Correspondence to Tao Zhu.

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Hu, X., Diao, Y., Hao, Z. et al. Histopathological analysis of the wall enhancement of the spinal dural arteriovenous fistulae’s draining veins. Acta Neurol Belg (2024). https://doi.org/10.1007/s13760-024-02483-3

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