Abstract
During the last five decades, there has been tremendous development in our understanding of cancer biology and the development of new and novel therapeutics to target cancer. However, despite these advances, cancer remains the second leading cause of death across the globe. Most cancer deaths are attributed to the development of resistance to current therapies. There is an urgent and unmet need to address cancer therapy resistance. Tetrandrine, a bis-benzyl iso-quinoline, has shown a promising role as an anti-cancer agent. Recent work from our laboratory and others suggests that tetrandrine and its derivatives could be an excellent adjuvant to the current arsenal of anti-cancer drugs. Herein, we provide an overview of resistance mechanisms to current therapeutics and review the existing literature on the anti-cancer effects of tetrandrine and its potential use for overcoming therapy resistance in cancer.
Keywords: Tetrandrine, Drug resistance, MDR/ ABCB1 transporter, Trail, Cancer, Nano-therapeutics.
Current Topics in Medicinal Chemistry
Title:Tetrandrine for Targeting Therapy Resistance in Cancer
Volume: 24 Issue: 12
Author(s): Ellen Nogueira Lima, Santosh Lamichhane, Pramod Bahadur K. C, Elisa Silva Ferreira, Sweaty Koul and Hari K. Koul*
Affiliation:
- Departments of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
- Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA
- LSU-LCMC Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
- Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
- Urology, LSUHSC-New Orleans, USA
Keywords: Tetrandrine, Drug resistance, MDR/ ABCB1 transporter, Trail, Cancer, Nano-therapeutics.
Abstract: During the last five decades, there has been tremendous development in our understanding of cancer biology and the development of new and novel therapeutics to target cancer. However, despite these advances, cancer remains the second leading cause of death across the globe. Most cancer deaths are attributed to the development of resistance to current therapies. There is an urgent and unmet need to address cancer therapy resistance. Tetrandrine, a bis-benzyl iso-quinoline, has shown a promising role as an anti-cancer agent. Recent work from our laboratory and others suggests that tetrandrine and its derivatives could be an excellent adjuvant to the current arsenal of anti-cancer drugs. Herein, we provide an overview of resistance mechanisms to current therapeutics and review the existing literature on the anti-cancer effects of tetrandrine and its potential use for overcoming therapy resistance in cancer.
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Cite this article as:
Lima Nogueira Ellen, Lamichhane Santosh, K. C Bahadur Pramod, Ferreira Silva Elisa, Koul Sweaty and Koul K. Hari*, Tetrandrine for Targeting Therapy Resistance in Cancer, Current Topics in Medicinal Chemistry 2024; 24 (12) . https://dx.doi.org/10.2174/0115680266282360240222062032
DOI https://dx.doi.org/10.2174/0115680266282360240222062032 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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