Skip to main content
Log in

mTORC2: The “Ace in the Hole” for a Broader Control of Epileptic Seizures?

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet 2019, 393: 689–701.

    Article  PubMed  Google Scholar 

  2. Xu C, Gong Y, Wang Y, Chen Z. New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments. Pharmacol Ther 2022, 233: 108026.

    Article  CAS  PubMed  Google Scholar 

  3. Gerasimenko A, Baldassari S, Baulac S. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy. Neurobiol Dis 2023, 182: 106144.

    Article  CAS  PubMed  Google Scholar 

  4. Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ. Targeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun 2023, 14: 7364.

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  5. Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, et al. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol 2018, 83: 311–327.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kim JK, Cho J, Kim SH, Kang HC, Kim DS, Kim VN, et al. Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy. J Clin Invest 2019, 129: 4207–4223.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, et al. Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nat Med 2019, 25: 1684–1690.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Reynolds C, King MD, Gorman KM. The phenotypic spectrum of SCN2A-related epilepsy. Eur J Paediatr Neurol 2020, 24: 117–122.

    Article  PubMed  Google Scholar 

  9. Gong Y, Xu C, Wang S, Wang Y, Chen Z. Computerized application for epilepsy in China: Does the era of artificial intelligence comes? Acta Neurol Scand 2022, 146: 732–742.

    Article  PubMed  Google Scholar 

  10. Xu C, Zhang S, Gong Y, Nao J, Shen Y, Tan B, et al. Subicular caspase-1 contributes to pharmacoresistance in temporal lobe epilepsy. Ann Neurol 2021, 90: 377–390.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This Research Highlight was supported by grants from the National Natural Science Foundation of China (82173796 and 82374064), and the Medical and Health Research Project of Zhejiang Province, China (2021RC097).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cenglin Xu.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, S., Guo, X., Huang, W. et al. mTORC2: The “Ace in the Hole” for a Broader Control of Epileptic Seizures?. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01187-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12264-024-01187-1

Navigation