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Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences

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Abstract

Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of biological responses to DNA damage, including apoptosis, mutagenesis, and carcinogenesis. The chemical nature and the amount of DNA lesions depend on the wavelength of UV radiation. UV type B (UVB, 290–320 nm) causes two main lesions, cyclobutane pyrimidine dimers (CPDs) and, with a lower yield, pyrimidine (6-4) pyrimidone photoproducts (6-4PPs). Their formation is a result of direct UVB photon absorption by DNA bases. UV type A (UVA, 320–400 nm) induces only cyclobutane dimers, which most likely arise via triplet–triplet energy transfer (TTET) from cell chromophores to DNA thymine bases. UVA is much more effective than UVB in inducing sensitized oxidative DNA lesions, such as single-strand breaks and oxidized bases. Of the latter, 8-oxo-dihydroguanine (8-oxodG) is the most frequent, being produced in several oxidation processes. Many recent studies reported novel, more detailed information about the molecular mechanisms of the photochemical reactions that underlie the formation of various DNA lesions. The information is mostly summarized and analyzed in the review. Special attention is paid to the oxidation reactions that are initiated by reactive oxygen species (ROS) and radicals generated by potential endogenous photosensitizers, such as pterins, riboflavin, protoporphyrin IX, NADH, and melanin. The review discusses the role that specific DNA photoproducts play in genotoxic processes induced in living systems by UV radiation of various wavelengths, including human skin carcinogenesis.

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Funding

This work was supported by a state contract with Moscow State University (no. 121032500058-7).

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  1. Biological Faculty, Moscow State University, 119991, Moscow, Russia

    G. Ya. Fraikin, N. S. Belenikina & A. B. Rubin

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Correspondence to G. Ya. Fraikin.

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Abbreviations: UVA, ultraviolet A (320–400 nm); UVB, ultra-violet B (290–320 nm); CPD, cyclobutane pyrimidine dimer; 6-4PP, pyrimidine (6-4) pyrimidone photoproduct; 8‑oxodG, 8-oxo-dihydroguanine; Ptr, pterin; Fop, 6‑formylpterin; Cap, 6-carboxypterin; Nep, neopterin; Bip, biopterin; H2Bip, 7,8-dihydrobiopterin; H4Bip, 5,6,7,8-tetrahydrobiopterin; PCD, programmed cell death; ROS, reactive oxygen species; TTET, triplet–triplet energy transfer.

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Fraikin, G.Y., Belenikina, N.S. & Rubin, A.B. Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences. Mol Biol 58, 1–16 (2024). https://doi.org/10.1134/S0026893324010047

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