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Optimization for the Contrast Enhancement at Head Computed Tomography Angiography by using the Patient Body Size Indexes: Identifying the Patient Body Size Indexes with the Most Significant Correlation

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Abstract

To identify the body size index (BSI) that exhibited the most significant correlation with intracranial artery enhancement on head computed tomography angiography (CTA) images. Our retrospective study received institutional review board approval, and the requirement for informed patient consent was waived. From April 2020 to October 2021, 99 patients with vascular disease underwent head CTA, during which the CT number (in Hounsfield units [HU]) of the middle cerebral artery at the proximal (M1) region was recorded on both unenhanced and arterial phase scans. We calculated the changes in contrast enhancement per iodine dose (ΔHU/gI) to assess the correlation with BSI. Subsequently, we conducted linear regression analyses between ΔHU/gI and BSI. To evaluate the effects of age, sex, BSI, and scan delay on theΔHU/gI, we used multivariate regression analysis. The ΔHU/gI of the middle cerebral artery during arterial phase was 15.8 ± 4.1 HU/gI. ΔHU/gI and body surface area (BSA) showed the strongest inverse correlation (r = 0.779). Among the BSIs considered in our study, BSA was the most important estimated factor for the ΔHU/gI of the middle cerebral artery on head CTA images acquired during the arterial phase. The BSA and scan delay had significant effects on ΔHU/gI (standardized regression: BSA −0.33, scan delay 0.02; p < 0.05, respectively). Patient BSA and scan delay significantly affected the contrast enhancement of M1 on head CTA images.

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Data Availability

This study was approved by our institutional review board.

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Not applicable.

Abbreviations

CTA :

computed tomography angiography

BW :

body weight

CT :

computed tomography

BMI :

body mass index

LBW :

lean body weight

BSI :

body size index

HU :

Hounsfield units

ROI :

region of interest

M1 :

middle cerebral artery

ΔHU :

increased CT number by contrast materials

ΔHU/gI :

increase in CT numbers per gram of iodine

HT :

body height

BSA :

body surface area

BV :

blood volume

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Authors and Affiliations

  1. Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, 288, Matsushima, Kurashiki, Okayama, 701-0193, Japan

    Hiroyasu Sanai, Takanori Masuda & Atsushi Ono

  2. Department of Radiology, Kawasaki Medical School, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan

    Akira Yamamoto & Tsutomu Tamada

  3. Department of Radiological technology, Kawasaki Medical School Hospital, 577, Matsushima, Kurashiki-city, Okayama, 701-0192, Japan

    Hiroyasu Sanai, Hiroyuki Ikenaga, Ryo Moriwake, Tetsuya Ishikawa & Koji Yoshida

Authors
  1. Hiroyasu Sanai
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  2. Takanori Masuda
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  3. Akira Yamamoto
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  4. Tsutomu Tamada
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  5. Hiroyuki Ikenaga
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  7. Tetsuya Ishikawa
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  9. Atsushi Ono
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Contributions

HS; (Conceived and designed the analysis, Collected the data, Contributed data or analysis tools, Performed the analysis, Wrote the paper)

TM; (Conceived and designed the analysis, Collected the data, Contributed data or analysis tools, Wrote the paper)

AY; (Conceived and designed the analysis, Collected the data)

TT; (Conceived and designed the analysis, Collected the data)

HI; (Conceived and designed the analysis, Collected the data)

RM; (Conceived and designed the analysis, Collected the data)

TI; (Conceived and designed the analysis, Collected the data)

KY; (Conceived and designed the analysis, Collected the data)

AO; (Conceived and designed the analysis, Collected the data)

Corresponding author

Correspondence to Hiroyasu Sanai.

Ethics declarations

Ethics Approval

This retrospective study was approved by our institutional review board for the Kawasaki Medical School Hospital (No. 5651-01), with the requirement for informed patient consent being waived.

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Not applicable.

Written Consent for Publication

This study was approved by our institutional review board.

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Sanai, H., Masuda, T., Yamamoto, A. et al. Optimization for the Contrast Enhancement at Head Computed Tomography Angiography by using the Patient Body Size Indexes: Identifying the Patient Body Size Indexes with the Most Significant Correlation. SN Compr. Clin. Med. 6, 29 (2024). https://doi.org/10.1007/s42399-024-01659-5

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