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High Inhibition Activity of CQDs-Macaranga tanarius Organic Framework Nanomaterial-Based Antibacterials

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Abstract

Antibacterial agent based on modification of Macaranga tanarius (M. tanarius) extract into CQDs@M. tanarius has been successfully synthesized and applied against Escherichia coli and Staphylococcus aureus. Macaranga tanarius plants were obtained from Buton Island, Southeast Sulawesi-Indonesia, and used as precursors for Carbon Quantum Dots (CQDs). In the synthesis, the dried leaves of M. tanarius were macerated, and then the filtrate was modified hydrothermally in a Teflon-lined stainless steel autoclave. The modification results produce nano-sized CQDs@M. tanarius particles. The PSA test confirmed this, which described the CQDs@M. tanarius particle size as 57.0 nm. The results of UV–Vis spectroscopy tests illustrate that the CQDs@M. tanarius molecules experience π → π* and n → π* electronic transitions at a wavelength of 367 nm. Meanwhile, in the FTIR spectroscopy test, stretching vibrations from the functional groups –OH, C–H, C=O, C–O, and the benzene ring were observed at wave numbers 3415.93 cm−1, 2976.16 cm−1, 1641.42 cm−1, 1274.95 cm−1, and 692.44 cm−1, respectively. Based on the antibacterial activity test, it is known that CQDs@M. tanarius has high inhibitory activity against E. coli and S. aureus. The resulting inhibition diameters are 15.82 mm and 11.24 mm, respectively. This high inhibitory diameter further illustrates the potential of CQDs@M. tanarius for its further application as an antibacterial material in the future.

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Data Availability

The datasets generated during and analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

We acknowledge the financial support from the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia under the Fundamental Research award grant no 16/E5/PG.02.00.PL/2023 and 950/UN56.D.01/PN.03.00/2023.

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Authors and Affiliations

  1. Biology Education Study Program, Faculty of Teacher Training and Education, Universitas, Sembilanbelas November Kolaka, Kabupaten Kolaka, Southeast Sulawesi, 93517, Indonesia

    Saparuddin Saparuddin

  2. Agrotechnology Study Program, Faculty of Agriculture, Fisheries and Animal Husbandry, Universitas Sembilanbelas November Kolaka, Kabupaten Kolaka, Southeast Sulawesi, 93517, Indonesia

    Djunarlin Tojang

  3. Chemistry Education Study Program, Faculty of Teacher Training and Education, Universitas Sembilanbelas November Kolaka, Kabupaten Kolaka, Southeast Sulawesi, 93517, Indonesia

    Alimuddin Alimuddin

  4. Department of Mathematics and Natural Sciences, Faculty of Tarbiyah, Institut Agama Islam Negeri (IAIN) Kendari, Kota Kendari, Southeast Sulawesi, 93116, Indonesia

    Zul Arham

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SS: Writing-original draft, investigation, formal analysis, data curation, conceptualization. DT: Formal analysis, validation, conceptualization. AA: Formal analysis, Validation. ZA: Writing-original draft, validation, data curation, writing-review and editing.

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Correspondence to Saparuddin Saparuddin or Zul Arham.

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Saparuddin Saparuddin declares that he has no conflict of interest. Djunarlin Tojang declares that she has no conflict of interest. Alimuddin Alimuddin declares that he has no conflict of interest. Zul Arham declares that he has no conflict of interest.

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Saparuddin, S., Tojang, D., Alimuddin, A. et al. High Inhibition Activity of CQDs-Macaranga tanarius Organic Framework Nanomaterial-Based Antibacterials. Indian J Microbiol (2024). https://doi.org/10.1007/s12088-024-01230-9

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