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Comparative Analysis of Enbloc or Piecemeal Removal After Enbloc Resection of Gastrointestinal Stromal Tumors

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Abstract

Objective

To investigate the safety and prognosis of enbloc or piecemeal removal after enbloc resection of a gastric GIST by comparing the clinical data of endoscopic en block resection and piecemeal removal (EP) and en block resection and complete removal (EC) of gastric GISTs.

Methods

A total of 111 (43 endoscopic piecemeal, and 68 complete removal) patients with gastric GIST’s ≥ 2 cm in diameter who underwent endoscopic therapy from January 2016 to June 2020 at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. In all cases, it was ensured that the tumor was intact during the resection, however, it was divided into EP group and EC group based on whether the tumor was completely removed or was cut into pieces which were then removed. The patients' recurrence-free survival rate and recurrence-free survival (RFS) were recorded.

Results

There was no statistically significant difference in RFS rates between the two groups (P = 0.197). The EP group had relatively high patient age, tumor diameter, risk classification, and operation time. However, there was no statistically significant difference in the number of nuclear fission images, postoperative hospitalization time, postoperative fasting time, complication rate and complication grading between the two groups (P > 0.05).

Conclusion

Endoscopic piecemeal removal after en block resection of gastric GIST is safe and effective and achieves similar clinical outcomes as complete removal after en block resection.

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Acknowledgments

The authors would like to thank all patients for their participation in this study. In addition, we want to thank Prof. Bingrong Liu and Prof. Saif Ullah for their help in revising this manuscript.

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Authors and Affiliations

  1. Department of Digestive Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China

    Jing-wen Zhang, Chang-qing Guo, Shan-shan Zhu, Nan Dai, Xiao-yu Wan, Ping Liu, Fang-bin Zhang & Xin-gung Cao

  2. Institute of Nature Conservation, Polish Academy of Sciences, 31120, Krakow, Poland

    Ghulam Nabi

  3. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China

    Yang Fu

Authors
  1. Jing-wen Zhang
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  2. Chang-qing Guo
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  8. Fang-bin Zhang
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  10. Xin-gung Cao
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Contributions

Data collection: JZ, ND, SZ, XW. Data analysis and drafting: JZ, PL, FZ, YF. Critical review and rewriting: GN, XC, CG.

Corresponding author

Correspondence to Xin-gung Cao.

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Conflict of interest

The scientific guarantors of this publication are Xinguang Cao. The authors of this manuscript (Jing-wen Zhang, Chang-qing Guo, Shan-shan Zhu, Ghulam Nabi, Nan Dai, Xiao-yu Wan, Ping Liu, Fang-bin Zhang, Yang Fu, Xin-gung Cao) declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors of this manuscript (Jing-wen Zhang, Chang-qing Guo, Shan-shan Zhu, Ghulam Nabi, Nan Dai, Xiao-yu Wan, Ping Liu, Fang-bin Zhang, Yang Fu, Xin-gung Cao) declare that they have no conflict of interests. The protocol was approved by The First Affiliated Hospital of Zhengzhou University (No.2022-KY-1236-001) and informed consent was waived. All the authors have followed the applicable ethical standards to maintain the research integrity without any duplication, fraud or plagiarism issues.

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Zhang, Jw., Guo, Cq., Zhu, Ss. et al. Comparative Analysis of Enbloc or Piecemeal Removal After Enbloc Resection of Gastrointestinal Stromal Tumors. Dig Dis Sci (2024). https://doi.org/10.1007/s10620-024-08340-w

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  • DOI: https://doi.org/10.1007/s10620-024-08340-w

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