An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. Reconstruction of the whole biosynthetic pathway in a heterologous host provides new perspectives for the biotechnological supply of this immunostimulant.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pulendran, B., Arunachalam, P. S. & O’Hagan, D. T. Nat. Rev. Drug Discov. 20, 454–475 (2021).
Pifferi, C., Fuentes, R. & Fernández-Tejada, A. Nat. Rev. Chem. 5, 197–216 (2021).
Lau, W. & Sattely, E. S. Science 349, 1224–1228 (2015).
Srinivasan, P. & Smolke, C. D. Nature 585, 614–619 (2020).
Biggs, B. W. et al. Science 374, 1563–1565 (2021).
Martin, L. B. B. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01538-5 (2024).
Reed, J. et al. Science 379, 1252–1264 (2023).
Zhang, J. et al. Nature 609, 341–347 (2022).
Medema, M. H., de Rond, T. & Moore, B. S. Nat. Rev. Genet. 22, 553–571 (2021).
Bradley, S. A. et al. Nat. Chem. Biol. 19, 1551–1560 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Courdavault, V., Papon, N. Accessing natural vaccine adjuvants. Nat Chem Biol 20, 401–403 (2024). https://doi.org/10.1038/s41589-024-01585-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-024-01585-6
