The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis

Title:The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis

Volume: 21

Author(s): Chitteti Divyavani, Pannala Padmaja and Pedavenkatagari Narayana Reddy*

Affiliation:

• Department of Chemistry, School of Science, Gitam Deemed to be University, Hyderabad, India

Keywords: Polyethylene glycol (PEG), Water, Aqueous biphasic solvent systems, Multicomponent reactions, Heterocyclic compounds.

Abstract: Polyethylene glycol (PEG) has become a popular solvent and green catalyst for a variety of chemical reactions. It is a stable and biodegradable polymeric catalyst used in organic synthesis because it may be recycled numerous times without significantly losing its catalytic activity. Recently, the use of PEG-H2O mixed solvent systems in organic synthesis has gained popularity. This article presents an overview of PEG-H2O solvent system-mediated organic reactions, with a main focus on the importance of the solvent system. The study also focuses on recent developments in the PEG-H2O solvent system-mediated synthesis of a number of heterocy-clic compounds. Important characteristics of these PEG-H2O solvent systems include high atom economies, gentle reaction conditions, faster reaction rates, readily isolated side products and high yields. Results from various reactions showed that the choice of proper ratio of PEG: H2O solvent system plays a key role in product yields.

Cite this article as:

Divyavani Chitteti, Padmaja Pannala and Narayana Reddy Pedavenkatagari*, The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis, Current Organic Synthesis 2024; 21 () . https://dx.doi.org/10.2174/0115701794284081240206043435