Skip to main content
Log in

Chimeric Monkey Born Alive with a High Contribution of Donor Cells

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Zheng C, Ballard EB, Wu J. The road to generating transplantable organs: From blastocyst complementation to interspecies chimeras. Development 2021, 148: dev195792.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tam PPL, Rossant J. Mouse embryonic chimeras: Tools for studying mammalian development. Development 2003, 130: 6155–6163.

    Article  CAS  PubMed  Google Scholar 

  3. Chen Y, Niu Y, Li Y, Ai Z, Kang Y, Shi H. Generation of Cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell 2015, 17: 116–124.

    Article  CAS  PubMed  Google Scholar 

  4. Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, et al. Improving cell survival in injected embryos allows primed pluripotent stem cells to generate chimeric Cynomolgus monkeys. Cell Rep 2018, 25: 2563-2576.e9.

    Article  CAS  PubMed  Google Scholar 

  5. Tachibana M, Sparman M, Ramsey C, Ma H, Lee HS, Penedo MCT, et al. Generation of chimeric Rhesus monkeys. Cell 2012, 148: 285–295.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cao J, Li W, Li J, Mazid MA, Li C, Jiang Y, et al. Live birth of chimeric monkey with high contribution from embryonic stem cells. Cell 2023, 186: 4996-5014.e24.

    Article  CAS  PubMed  Google Scholar 

  7. Wu J, Izpisua Belmonte JC. Dynamic pluripotent stem cell states and their applications. Cell Stem Cell 2015, 17: 509–525.

    Article  CAS  PubMed  Google Scholar 

  8. Gafni O, Weinberger L, Mansour AA, Manor YS, Chomsky E, Ben-Yosef D, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013, 504: 282–286.

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Guo G, von Meyenn F, Rostovskaya M, Clarke J, Dietmann S, Baker D, et al. Epigenetic resetting of human pluripotency. Dev Camb Engl 2017, 144: 2748–2763.

    CAS  Google Scholar 

  10. Mazid MA, Ward C, Luo Z, Liu C, Li Y, Lai Y, et al. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature 2022, 605: 315–324.

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Theunissen TW, Powell BE, Wang H, Mitalipova M, Faddah DA, Reddy J, et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 2014, 15: 471–487.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 2017, 169: 243-257.e25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, et al. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 2019, 366: eaax7890.

    Article  CAS  PubMed  Google Scholar 

  14. Niu Y, Sun N, Li C, Lei Y, Huang Z, Wu J, et al. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 2019, 366: eaaw5754.

    Article  CAS  PubMed  Google Scholar 

  15. Zheng C, Hu Y, Sakurai M, Pinzon-Arteaga CA, Li J, Wei Y, et al. Cell competition constitutes a barrier for interspecies chimerism. Nature 2021, 592: 272–276.

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

J.W. is a New York Stem Cell Foundation–Robertson Investigator and Virginia Murchison Linthicum Scholar in Medical Research. Research in the Wu laboratory is supported by the National Institutes of Health (UM1HG011996, R01HD103627, and R01GM138565), NYSCF, ARSM, and The Welch Foundation (I-2088).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jun Wu.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, J., Wu, J. Chimeric Monkey Born Alive with a High Contribution of Donor Cells. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01192-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12264-024-01192-4

Navigation