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ODRNN: optimized deep recurrent neural networks for automatic detection of leukaemia

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Abstract

Leukaemia image classification involves using machine learning, and often deep learning, techniques to automatically analyse medical images and categorize them into different classes, such as different types of leukaemia or distinguishing between leukaemia and normal cells. Leukaemia, a kind of cancer that may occur in individuals of all ages, including kids and adults, is a significant contributor to worldwide death rates. Additionally, inspection under a microscope, leukemic cells look and develop similarly to normal cells, making identification more difficult. Traditional machine learning models may struggle to scale effectively with the increasing size and complexity of medical image datasets. As the datasets grow, the limitations of manually engineered features and shallow architectures become more apparent. In the context of leukaemia image classification using deep learning, the primary aim is to develop a robust and accurate model that can effectively distinguish between different types of leukaemia or between leukaemia and normal cells within medical images. As a consequence, the study provided a unique deep learning approach known as optimized deep recurrent neural network (ODRNN) for identifying leukaemia sickness by analysing microscopic images of blood samples. Deep recurrent neural networks (DRNNs) are used in the recommended strategy for diagnosing leukaemia, and then, the red deer optimization algorithm (RDOA) applies to optimize the weight gained by DRNN. The weight of DRNN from RDOA will be tuned on the deer roaring rate behaviour. The model that has been proposed is evaluated on two openly accessible leukaemia blood sample datasets, AML, ALL_IDB1, and ALL_IDB2. The research work uses statistical metrics related to disease including specificity, recall, accuracy, precision, and F1-score to assess the effectiveness of the proposed model for identification and classification. The proposed method achieves highly impressive results, with scores of 98.96%, 99.85%, 99.98%, 99.23%, and 99.98%, respectively. In conclusion, deep learning-based image classification for leukaemia has emerged as a powerful and promising approach in the field of medical diagnostics. Leveraging ODRNN, researchers and practitioners have made significant strides in automating the process of identifying and classifying leukaemia cells in medical images.

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Data availability

The datasets generated during and/or analysed during the current study are available in the UCI repository.

References

  1. Ahirwar, D.R., Nigam, R.K., Parmar, D.: A study of leukaemias profile in central India. Trop. J. Pathol. Microbiol. 4(2), 2456–1487 (2018)

    Article  Google Scholar 

  2. Van Zwieten, R., Verhoeven, A.J., Roos, D.: Inborn defects in the antioxidant systems of human red blood cells. Free Radical Biol. Med. 67, 377–386 (2014)

    Article  Google Scholar 

  3. Nolan, J.P., Jones, J.C.: Detection of platelet vesicles by flow cytometry. Platelets 28(3), 256–262 (2017)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  4. Talaat, F.M., Gamel, S.A.: Machine learning in detection and classification of Leukaemia using C-NMC_Leukaemia. Multimedia Tools and Applications, pp. 1–14 (2023)

  5. Hegde, R.B., Prasad, K., Hebbar, H., Singh, B.M.K., Sandhya, I.: Automated decision support system for detection of leukaemia from peripheral blood smear images. J. Digit. Imaging 33, 361–374 (2019)

    Article  PubMed Central  Google Scholar 

  6. Das, N.N., et al.: Automated deep transfer learning-based approach for detection of COVID-19 infection in chest X-rays. Irbm 43(2), 114–119 (2022)

    Article  Google Scholar 

  7. Ehrenstein, V., Nielsen, H., Pedersen, A.B., Johnsen, S.P., Pedersen, L.: Clinical epidemiology in the era of big data: new opportunities, familiar challenges. Clin. Epidemiol. Epidemiol. 9, 245–250 (2017)

    Article  Google Scholar 

  8. Anilkumar, K.K., Manoj, V.J., Sagi, T.M.: A survey on image segmentation of blood and bone marrow smear images with emphasis to automated detection of leukaemia. Biocybern. Biomed. Eng. 40(4), 1406–1420 (2020)

    Article  Google Scholar 

  9. Ratley, A., Minj, J., Patre, P.: Leukaemia disease detection and classification using machine learning approaches: a review. In: 2020 First International Conference on Power, Control and Computing Technologies (ICPC2T), pp. 161–165, IEEE (2020)

  10. Kumar, N., et al.: Efficient automated disease diagnosis using machine learning models. J. Healthcare Eng. (2021)

  11. Das, P.K., Meher, S.: An efficient deep convolutional neural network based detection and classification of acute lymphoblastic leukaemia. Expert Syst. Appl. 183, 115311 (2021)

    Article  Google Scholar 

  12. Agustin, R.I., Arif, A., Sukorini, U.: Classification of immature white blood cells in acute lymphoblastic Leukaemia L1 using neural networks particle swarm optimization. Neural Comput. Appl.Comput. Appl. 33(17), 10869–10880 (2021)

    Article  Google Scholar 

  13. Acharya, V., Ravi, V., Pham, T. D., Chakraborty, C.: Peripheral blood smear analysis using automated computer-aided diagnosis system to identify acute myeloid Leukaemia. IEEE Transactions on Engineering Management (2021)

  14. Claro, M.L., de MS Veras, R., Santana, A.M., Vogado, L.H.S., Junior, G.B., de Medeiros, F.N., Tavares, J.M.R.: Assessing the impact of data augmentation and a combination of cnns on leukaemia classification. Inf. Sci. 609, 1010–1029 (2022)

    Article  Google Scholar 

  15. Jawahar, M., Sharen, H., Gandomi, A.H.: ALNett: a cluster layer deep convolutional neural network for acute lymphoblastic leukaemia classification. Comput. Biol. Med.. Biol. Med. 148, 105894 (2022)

    Article  Google Scholar 

  16. Abhishek, A., Jha, R.K., Sinha, R., Jha, K.: Automated classification of acute Leukaemia on a heterogeneous dataset using machine learning and deep learning techniques. Biomed. Signal Process. Control 72, 103341 (2022)

    Article  Google Scholar 

  17. Das, P.K., Sahoo, B., Meher, S.: An efficient detection and classification of acute Leukaemia using transfer learning and orthogonal softmax layer-based model. In: IEEE/ACM Transactions on Computational Biology and Bioinformatics (2022)

  18. Saeed, U., Kumar, K., Khuhro, M.A., Laghari, A.A., Shaikh, A.A., Rai, A.: Deepleuknet—a CNN based microscopy adaptation model for acute lymphoblastic Leukaemia classification. Multimedia Tools and Applications, pp. 1–25 (2023)

  19. Batool, A., Byun, Y.C.: (2023). Lightweight efficientnetb3 model based on depthwise separable convolutions for enhancing classification of leukaemia white blood cell images. IEEE access

  20. Seyala, N., Abdullah, S.N.: Cluster analysis on longitudinal data of patients with kidney dialysis using a smoothing cubic B-spline model. Int. J. Math. Statistics Comput. Sci. 2, 85–95 (2024)

    Article  Google Scholar 

  21. Ali, A.M., Mohammed, M.A.: A comprehensive review of artificial intelligence approaches in omics data processing: evaluating progress and challenges. Int. J. Math. Statistics Comput. Sci. 2, 114–167 (2024)

    Article  Google Scholar 

  22. Hossain, M.A., Islam, A.M., Islam, S., Shatabda, S., Ahmed, A.: Symptom based explainable artificial intelligence model for leukaemia detection. IEEE Access 10, 57283–57298 (2022)

    Article  Google Scholar 

  23. https://www.kaggle.com/datasets/avk256/cnmc-Leukaemia

  24. https://www.kaggle.com/datasets/akhiljethwa/blood-cancer-%20920%20image-dataset

  25. https://www.kaggle.com/datasets/andrewmvd/Leukaemia-classification

  26. Hermans, M., Schrauwen, B.: Training and analysing deep recurrent neural networks. Advances in neural information processing systems, p. 26 (2013)

  27. Fard, A.F., Hajiaghaei-Keshteli, M.: Red deer algorithm (RDA); a new optimization algorithm inspired by Red Deers’ mating. In: International Conference on Industrial Engineering, (Vol. 12, pp. 331–342), IEEE (2016)

  28. Shree, K.D., Janani, B.: Classification of leucocytes for leukaemia detection. Res J Eng Technol 10(2), 59–66 (2019)

    Article  Google Scholar 

  29. Kumar, A., Priyanka, S., Dhanashree, K., Praveen, V., Rekha, R.: Efficient binary grasshopper optimization based neural network algorithm for bitcoin value prediction. Int. J. Nonlinear Anal. Appl. 13, 53–60 (2022). https://doi.org/10.22075/ijnaa.2022.6330

    Article  Google Scholar 

  30. Arunachalam, S.K., Rekha, R.: A novel approach for cardiovascular disease prediction using machine learning algorithms. Concurr. Comput. Pract. Exp. 34(19), e7027 (2022)

    Article  Google Scholar 

  31. Dhanashree, K., Jayabal, P., Kumar, A., Logeswari, S., Priya, K.: Fingernail analysis for early detection and diagnosis of diseases using machine learning techniques. Int. J. Nonlinear Anal. Appl. 13, 61–69 (2022). https://doi.org/10.22075/ijnaa.2022.6331

    Article  Google Scholar 

  32. Liu, J., Hua, J., Chellappa, V., Petrick, N., Sahiner, B., Farooqui, M., Summers, R.M.: Automatic detection of axillary lymphadenopathy on CT scans of untreated chronic lymphocytic Leukaemia patients. In: Medical Imaging 2012: Computer-Aided Diagnosis (Vol. 8315, pp. 107–113), SPIE (2012)

  33. Tharsanee, R.M., Soundariya, R.S., Kumar, A.S., Karthiga, M., Sountharrajan, S.: Deep convolutional neural network–based image classification for COVID-19 diagnosis. In: Data science for COVID-19 (pp. 117–145). Academic Press (2021)

  34. Aghamaleki, F.S., Mollashahi, B., Nosrati, M., Moradi, A., Sheikhpour, M., Movafagh, A.: Application of an artificial neural network in the diagnosis of chronic lymphocytic leukaemia. Cureus 11(2), 1–7 (2019)

    Google Scholar 

  35. Kumar, A.S., Rekha, R.: An improved hawks optimizer-based learning algorithms for cardiovascular disease prediction. Biomed. Signal Process. Control 81, 104442 (2023)

    Article  Google Scholar 

  36. Priyanka, S., Praveen, V., Sivapriya, G.: Hindrance detection and avoidance in driverless cars through deep learning techniques. In: Advances in Deep Learning Applications for Smart Cities (pp. 69–100). IGI Global (2022)

  37. Rao, G.E., Rajitha, B., Srinivasu, P.N., Ijaz, M.F., Woźniak, M.: Hybrid framework for respiratory lung diseases detection based on classical CNN and quantum classifiers from chest X-rays. Biomed. Signal Process. Control 88, 105567 (2024)

    Article  Google Scholar 

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KDS contributed to conceptualization, data curation, formal analysis, methodology, writing–original draft, and writing–review and editing. SL was involved in investigation, formal analysis, and supervision.

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Correspondence to K. Dhana Shree.

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Shree, K.D., Logeswari, S. ODRNN: optimized deep recurrent neural networks for automatic detection of leukaemia. SIViP (2024). https://doi.org/10.1007/s11760-024-03062-y

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