Abstract
The unearthing of various forms of broad and narrow-spectrum antibiotics have helped mankind combat various forms of microbic infections ranging from protozoal to bacterial. The applicability of antibiotics has been decisive in a wide range of frontline therapeutic dealings. An extensive use of antibiotics and certain genetic modifications in microbes has paved the way for a new issue to be answered by the scientific community, an antibiotic resistance. An unparallel infections triggered by multidrug-resistant organisms (MDRO) account to be a major cause of mortality and morbidity, today this situation demands the development of alternative strategies of cure and medicine by the scientific community. Study shows the amplification of the effect of antibiotics may be a possible route to address antibiotic resistivity. The assortment of various surface properties of nanoparticles (NPs) coupled with their ability to efficiently bind with bacterial surfaces leading to the rupture and lysis of cell deliberates potential strategies to manage infections caused by MDROs.The present study scrutinizes the amplification of the antibacterial activity of ciprofloxacin (CIP) against the bacterial strains of Staphylococcus aureus, Escherichia coli, Pseudomonas and Streptococcus mutans on coupling with synthesized copper, silver and zinc oxide NPs (ZnO NPs) by disc diffusion technique. The current study describes the efficacious synthesis and characterization of ZnONP, copper Nps (CuNPs) and silver NPs (AgNPs) followed by the induced amplification of the antibacterial activity of CIP by coupling it with synthesized metal/metal oxide (M/MO NP). The synthesized M/MO NPs were characterized using XRD and FE-SEM studies and TEM. The results indicated that among the ZnONP, AgNP, the Cu NPs potentiate the bactericidal efficacy of CIP antibiotics.
Similar content being viewed by others
References
Lee N Y, Ko W C and Hsueh P R 2019 Front Pharmacol. 10 1153
Huh A J and Kwon Y J 2011 J. Control Release 156 128
Patel G, Huprikar S, Factor S H, Jenkins S G and Calfee D P 2008 Infect. Control Hosp. Epidemiol. 29 1099
Frieri M, Kumar K and Boutin A 2017 J. Infection Public Health 10 369
Singh R, Smitha M S and Singh S P 2014 J. Nanosci. Nanotechnol. 14 4745
Wang L, Hu C and Shao L 2017 Int. J. Nanomed. 12 1227
Arakha M, Pal S, Samantarrai D, Panigrahi T K, Mallick B C, Pramanik K et al 2015 Sci. Rep. 5 14813
Grass G, Rensing C and Solioz M 2011 Appl. Environ. Microb. 77 1541
Sirelkhatim A, Mahmud S, Seeni A, Kaus N M, Ann L C, Bakhori S M et al 2015 Nanomicro Lett. 7 219
Koch K A and Thiele D J 1998 Mol. Cell Biol. 18 2514
Colon G, Ward B C and Webster T J 2006 J. Biomed. Mater. Res. 78 595
Padmavathy N and Vijayaraghavan R 2008 Sci. Technol. Adv. Mater. 9 035004
Mathur P, Jha S, Ramteke S and Jain N K 2018 Artif. Cells Nanomed. Biotechnol. 46 115
Mallmann E J, Cunha F A, Castro B N, Maciel A M, Menezes E A, Fechine P B et al 2015 Rev. Inst. Med. Trop. Sao Paul 57 165
Paladini F and Pollini M 2019 Materials (Basel). 12 2540
Asma M T and Javed I M 2022 Mater. Today: Proc. 49 632
Tatagar A and Phaniband M A 2018 Adv. Sci. Lett. 24 807
Dadosh T 2009 Mater. Lett. 63 2236
Case C L and Johnson T R 1984 Laboratory experiments in microbiology (Benjamin Cummings, California, Calif, USA)
Al-Bayati F A 2008 J. Ethnopharmacol. 116 403
Wayne P A 2012 Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing. Performance standards for antimicrobial susceptibility testing Twenty-second informational supplement. Document M100- S22, CLSI
Meruvu H, Vangalapati M, Chippada S C and Bammidib S R 2011 Rasayan J. Chem. 4 217
Ameer A, Arham S A, Mohammad O, Mohammad S K, Sami S H and Adnan M 2012 Int. J. Nanomed. 7 6003
Hernández-Sierra J F, Ruiz F, Cruz Pena D C, Martínez-Gutiérrez F, Martínez A E, de Jesús Pozos Guillén A et al 2008 Nanomedicine 4 237
Ahamed M, Alhadlaq H A, Khan M M, Karuppiah P and Aldhabi N A 2014 J. Nanomater. 2014 1
Patra P, Nitai Debnath S M, Pramanik P and Goswami A 2014 Bull. Mater. Sci. 37 199
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Tatagar, A.M., Moodi, J.I. & Lamani, S.D. A systematized comparative account of antimicrobic explorations of ciprofloxacin couple of zinc oxide, copper and silver nanoparticles. Bull Mater Sci 47, 57 (2024). https://doi.org/10.1007/s12034-023-03135-7
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s12034-023-03135-7