Abstract
Oxidative stress is a sophisticated situation that orignates from the accumulation of reactive free radicals within cellular compartments. The antioxidant mechanism of the MnSOD enzyme facilitates the removal of these lethal oxygen species from cellular components. The main goal of this pertained work is to study the contribution of the SOD2 (rs4880; p.Val16Ala) variant to the development of bronchial asthma among children. The study’s design was carried out based on a total of 254 participants including 127 asthmatic children (91 atopic and 36 non-atopic) along with 127 unrelated healthy controls. Allelic discrimination analysis was executed using the T-ARMS-PCR protocol. This potential variant conferred a significant association with decreased risk of bronchial asthmatic children under allelic (OR = 0.56, P-value = 0.002), recessive (OR = 0.32, P-value = 0.011), and dominant (OR = 0.51, P-value = 0.040) models. Additionally, atopic and non-atopic asthmatic children indicated a protection against bronchial asthma development under allelic, and dominant models (p-value < 0.05). Our findings suggested that the SOD2*rs4880 variant was correlated with decreased risk of childhood bronchial asthma.
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Data Availability
The dataset used in the preparation of this study will be available from the corresponding author upon reasonable request.
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NHA contributed toward conceptualization, methodology, investigation, writing – review & editing, and supervision. HEAS contributed toward data curation, formal analysis, validation, and writing – review & editing. HKB contributed toward formal analysis, methodology, writing – original draft, and data curation. EAO contributed toward methodology, formal analysis, and data curation. SAM contributed toward methodology, formal analysis, and visualization. EIAS contributed toward methodology, formal analysis, visualization, and data curation. ZRA contributed toward methodology formal analysis, and writing – review & editing. SM contributed toward methodology, formal analysis, and data curation. MFS contributed toward methodology, formal analysis, and data curation. MAEl‑E contributed toward methodology, formal analysis, and visualization. RE contributed toward methodology, formal analysis, visualization, data curation, and writing – review & editing. AME contributed toward methodology, formal analysis, and visualization. AIA contributed toward methodology, software, formal analysis, data curation, and writing – review & editing. RME contributed toward project administration, conceptualization, methodology, software, formal analysis, data curation, validation, investigation, and writing – review & editing.
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Anber, N.H., Ahmed Shahin, H.E., Badawy, H.K. et al. Potential Impact of SOD2 (rs4880; p.Val16Ala) Variant with the Susceptibility for Childhood Bronchial Asthma. Biochem Genet (2024). https://doi.org/10.1007/s10528-024-10742-4
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DOI: https://doi.org/10.1007/s10528-024-10742-4