Abstract
Objectives
There is a rapidly growing body of research into mindfulness-based interventions (MBIs) for People Experiencing Psychosis. This study aimed to examine the feasibility of a novel, 6-week 1:1 MBI, as well as the feasibility of the assessment and analysis of between-session practice and metacognitive beliefs as predictors of Quality of Life (QoL) outcomes.
Method
A case series design was used. Eight participants were recruited, with seven completers. The primary outcome, QoL, was assessed up to four times per week, with additional outcomes taken weekly, pre-post, and pre-mid-post. Multilevel modelling was used to examine predictors.
Results
The methods and intervention were feasible. However, most participants preferred shorter, 30-min appointments with one mindfulness practice. Between-session practice varied significantly (0–220 min total), with three participants completing no between-session practice. Pre- to mid-intervention improvement in metacognitive beliefs was lost at post-intervention assessment. Non-significant trends of improvement were noted in most outcomes.
Conclusions
A full-scale trial is recommended to assess the intervention and predictors, with adjustment of intervention length and post-intervention assessment suggested. Future research should also further examine metacognitive processes and factors associated with between-session practice adherence for people experiencing psychosis accessing MBIs.
Preregistration
This study was not preregistered. However, detailed study and intervention protocols were created as part of the ethics application, which was followed throughout the study. These documents are available upon request.
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Data Availability
Anonymized data will be made available upon request.
References
Addington, D., Addington, J., & Schissel, B. (1990). A depression rating scale for schizophrenics. Schizophrenia Research, 3(4), 247–251. https://doi.org/10.1016/0920-9964(90)90005-R
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.).
Baek, E. K., Moeyaert, M., Petit-Bois, M., Beretvas, S. N., Van den Noortgate, W., & Ferron, J. M. (2014). The use of multilevel analysis for integrating single-case experimental design results within a study and across studies. Neuropsychological Rehabilitation, 24(3–4), 590–606. https://doi.org/10.1080/09602011.2013.835740
Beer, U. M., Neerincx, M. A., Morina, N., & Brinkman, W.-P. (2017). Virtual agent-mediated appraisal training: A single case series among Dutch firefighters. European Journal of Psychotraumatology, 8(1), 1378053. https://doi.org/10.1080/20008198.2017.1378053
Bowen, D. J., Kreuter, M., Spring, B., Cofta-Woerpel, L., Linnan, L., Weiner, D., Bakken, S., Kaplan, C. P., Squiers, L., Fabrizio, C., & Fernandez, M. (2009). How we design feasibility studies. American Journal of Preventive Medicine, 36(5), 452–457. https://doi.org/10.1016/j.amepre.2009.02.002
Carmody, J., & Baer, R. A. (2009). How long does a mindfulness-based stress reduction program need to be? A review of class contact hours and effect sizes for psychological distress. Journal of Clinical Psychology, 65(6), 627–638. https://doi.org/10.1002/jclp.20555
Chadwick, P. (2006). Person-based cognitive therapy for distressing psychosis. Wiley. https://doi.org/10.1002/9780470713075
Chadwick, P. (2014). Mindfulness for psychosis. British Journal of Psychiatry, 204(5), 333–334. https://doi.org/10.1192/bjp.bp.113.136044
Chadwick, P., Newman Taylor, K., & Abba, N. (2005). Mindfulness groups for people with psychosis. Behavioural and Cognitive Psychotherapy, 33(3), 351–359. https://doi.org/10.1017/S1352465805002158
Chadwick, P., Hember, M., Symes, J., Peters, E., Kuipers, E., & Dagnan, D. (2008). Responding mindfully to unpleasant thoughts and images: Reliability and validity of the Southampton mindfulness questionnaire (SMQ). British Journal of Clinical Psychology, 47(4), 451–455. https://doi.org/10.1348/014466508X314891
Chadwick, P., Hughes, S., Russell, D., Russell, I., & Dagnan, D. (2009). Mindfulness groups for distressing voices and paranoia: A replication and randomized feasibility trial. Behavioural and Cognitive Psychotherapy, 37(4), 403–412. https://doi.org/10.1017/S1352465809990166
Cramer, H., Lauche, R., Haller, H., Langhorst, J., & Dobos, G. (2016). Mindfulness- and acceptance-based interventions for psychosis: A systematic review and meta-analysis. Global Advances in Health and Medicine, 5(1), 30-43. https://doi.org/10.7453/gahmj.2015.083
Davis, L., & Kurzban, S. (2012). Mindfulness-based treatment for people with severe mental illness: A literature review. American Journal of Psychiatric Rehabilitation, 15(2), 202–232. https://doi.org/10.1080/15487768.2012.679578
Dennick, L., Fox, A. P., & Walter-Brice, A. (2013). Mindfulness groups for people experiencing distressing psychosis: An interpretative phenomenological analysis. The Mental Health Review, 18(1), 32–43. https://doi.org/10.1108/13619321311310096
Drake, R., Haddock, G., Tarrier, N., Bentall, R., & Lewis, S. (2007). The Psychotic Symptom Rating Scales (PSYRATS): Their usefulness and properties in first episode psychosis. Schizophrenia Research, 89(1), 119–122. https://doi.org/10.1016/j.schres.2006.04.024
Evans, C., Mellor-Clark, J., Margison, F., Barkham, M., Audin, K., Connell, J., & McGrath, G. (2000). CORE: Clinical Outcomes in Routine Evaluation. Journal of Mental Health, 9(3), 247–255. https://doi.org/10.1080/jmh.9.3.247.255
Flavell, J. H. (1979). Metacognition and cognitive monitoring: A new area of cognitive–developmental inquiry. American Psychologist, 34(10), 906–911. https://doi.org/10.1037/0003-066X.34.10.906
Gold, L. H. (2014). DSM-5 and the assessment of functioning: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). The Journal of the American Academy of Psychiatry and the Law, 42(2), 173–181.
Haddock, G., McCarron, J., Tarrier, N., & Faragher, E. B. (1999). Scales to measure dimensions of hallucinations and delusions: The Psychotic Symptom Rating Scales (PSYRATS). Psychological Medicine, 29(4), 879–889. https://doi.org/10.1017/S0033291799008661
Hasson-Ohayon, I., Avidan-Msika, M., Mashiach-Eizenberg, M., Kravetz, S., Rozencwaig, S., Shalev, H., & Lysaker, P. H. (2015). Metacognitive and social cognition approaches to understanding the impact of schizophrenia on social quality of life. Schizophrenia Research, 161(2), 386–391. https://doi.org/10.1016/j.schres.2014.11.008
Helbig, S., & Fehm, L. (2004). Problems with homework in CBT: Rare exception or rather frequent? Behavioural and Cognitive Psychotherapy, 32(3), 291–301. https://doi.org/10.1017/S1352465804001365
Hochheiser, J., Lundin, N. B., & Lysaker, P. H. (2020). The independent relationships of metacognition, mindfulness, and cognitive insight to self-compassion in schizophrenia. The Journal of Nervous and Mental Disease, 208(1), 1–6. https://doi.org/10.1097/NMD.0000000000001065
Hothorn, T., Hornik, K., van de Wiel, M. A., & Zeileis, A. (2008). Implementing a class of permutation tests: The coin package. Journal of Statistical Software, 28(8), 1–23. https://doi.org/10.18637/jss.v028.i08
Hox, J., & McNeish, D. (2020). Small samples in multilevel modeling. In J. Hox & D. McNeish (Eds.), Small sample size solutions: A guide for applied researchers and practitioners (pp. 215–225). Routledge.
Jacobsen, P., Morris, E., Johns, L., & Hodkinson, K. (2011). Mindfulness groups for psychosis; Key issues for implementation on an inpatient unit. Behavioural and Cognitive Psychotherapy, 39(3), 349–353. https://doi.org/10.1017/S1352465810000639
Jacobsen, P., Richardson, M., Harding, E., & Chadwick, P. (2019). Mindfulness for psychosis groups; within-session effects on stress and symptom-related distress in routine community care. Behavioural and Cognitive Psychotherapy, 47(4), 421–430. https://doi.org/10.1017/S1352465818000723
Jansen, J. E., Gleeson, J., Bendall, S., Rice, S., & Alvarez-Jimenez, M. (2020). Acceptance- and mindfulness- based interventions for persons with psychosis: A systematic review and meta-analysis. Schizophrenia Research, 215, 25–37. https://doi.org/10.1016/j.schres.2019.11.016
Kabat-Zinn, J. (1994). Wherever you go, there you are: Mindfulness meditation in everyday life. Hachette Books.
Kabat-Zinn, J. (2013). Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness (2nd ed.). Random House Publishing Group.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261–276. https://doi.org/10.1093/schbul/13.2.261
Kazdin, A. E. (2021). Single-case experimental designs: Characteristics, changes, and challenges. Journal of the Experimental Analysis of Behavior, 115(1), 56–85. https://doi.org/10.1002/jeab.638
Khoury, B., Lecomte, T., Gaudiano, B. A., & Paquin, K. (2013). Mindfulness interventions for psychosis: A meta-analysis. Schizophrenia Research, 150(1), 176–184. https://doi.org/10.1016/j.schres.2013.07.055
Köhler, O., Horsdal, H. T., Baandrup, L., Mors, O., & Gasse, C. (2016). Association between Global Assessment of Functioning scores and indicators of functioning, severity, and prognosis in first-time schizophrenia. Clinical Epidemiology, 8, 323–332. https://doi.org/10.2147/CLEP.S109036
Kravariti, E., Reeve-Mates, C., Pires, R. D. G., Tsakanikos, E., Hayes, D., Renshaw, S., McAllister, S., Bhavsar, V., Patterson, P., Daley, E., Stewart, J., Pritchard, M., Shetty, H., Ramsay, R., Perez-Iglesias, R., & McGuire, P. (2018). Effectiveness of automated appointment reminders in psychosis community services: A randomised controlled trial. BJPsych Open, 4(1), 15–17. https://doi.org/10.1192/bjo.2017.7
Kring, A. M., Gur, R. E., Blanchard, J. J., Horan, W. P., & Reise, S. P. (2013). The Clinical Assessment Interview for Negative Symptoms (CAINS): Final development and validation. American Journal of Psychiatry, 170(2), 165–172. https://doi.org/10.1176/appi.ajp.2012.12010109
Kronmüller, K.-T., von Bock, A., Grupe, S., Büche, L., Gentner, N. C., Rückl, S., Marx, J., Joest, K., Kaiser, S., Vedder, H., & Mundt, C. (2011). Psychometric evaluation of the Psychotic Symptom Rating Scales. Comprehensive Psychiatry, 52(1), 102–108. https://doi.org/10.1016/j.comppsych.2010.04.014
Kumari, S., Malik, M., Florival, C., Manalai, P., & Sonje, S. (2017). An assessment of five (PANSS, SAPS, SANS, NSA-16, CGI-SCH) commonly used symptoms rating scales in schizophrenia and comparison to newer scales (CAINS, BNSS). Journal of Addiction Research & Therapy, 8(3). https://doi.org/10.4172/2155-6105.1000324
Lancaster, G. A., Dodd, S., & Williamson, P. R. (2004). Design and analysis of pilot studies: Recommendations for good practice. Journal of Evaluation in Clinical Practice, 10(2), 307–312. https://doi.org/10.1111/j.2002.384.doc.x
Lloyd, A., White, R., Eames, C., & Crane, R. (2018). The utility of home-practice in mindfulness-based group interventions: A systematic review. Mindfulness, 9(3), 673–692. https://doi.org/10.1007/s12671-017-0813-z
Lobo, M. A., Moeyaert, M., Cunha, A. B., & Babik, I. (2017). Single-case design, analysis, and quality assessment for intervention research. Journal of Neurologic Physical Therapy, 41(3), 187–197. https://doi.org/10.1097/NPT.0000000000000187
Louise, S., Fitzpatrick, M., Strauss, C., Rossell, S. L., & Thomas, N. (2018). Mindfulness- and acceptance-based interventions for psychosis: Our current understanding and a meta-analysis. Schizophrenia Research, 192, 57–63. https://doi.org/10.1016/j.schres.2017.05.023
Louise, S., Rossell, S. L., & Thomas, N. (2019). The acceptability, feasibility and potential outcomes of an individual mindfulness-based intervention for hearing voices. Behavioural and Cognitive Psychotherapy, 47(2), 200–216. https://doi.org/10.1017/S1352465818000425
Lysaker, P. H., McCormick, B. P., Snethen, G., Buck, K. D., Hamm, J. A., Grant, M., Nicolò, G., & Dimaggio, G. (2011). Metacognition and social function in schizophrenia: Associations of mastery with functional skills competence. Schizophrenia Research, 131(1), 214–218. https://doi.org/10.1016/j.schres.2011.06.011
Lysaker, P. H., Kukla, M., Vohs, J. L., Schnakenberg Martin, A. M., Buck, K. D., & Hasson Ohayon, I. (2019). Metacognition and recovery in schizophrenia: From research to the development of metacognitive reflection and insight therapy. Journal of Experimental Psychopathology, 10(1), 2043808718814992. https://doi.org/10.1177/2043808718814992
Mathieu, J. E., Aguinis, H., Culpepper, S. A., & Chen, G. (2012). Understanding and estimating the power to detect cross-level interaction effects in multilevel modeling. Journal of Applied Psychology, 97(5), 951–966. https://doi.org/10.1037/a0028380
Morrison, A. P. (2001). The interpretation of intrusions in psychosis: An integrative cognitive approach to hallucinations and delusions. Behavioural and Cognitive Psychotherapy, 29(3), 257–276. https://doi.org/10.1017/S1352465801003010
Morrison, A. P., Gumley, A. I., Ashcroft, K., Manousos, I. R., White, R., Gillan, K., Wells, A., & Kingdon, D. (2011). Metacognition and persecutory delusions: Tests of a metacognitive model in a clinical population and comparisons with non-patients. British Journal of Clinical Psychology, 50(3), 223–233. https://doi.org/10.1348/014466510X511141
Nezlek, J. B. (2007). A multilevel framework for understanding relationships among traits, states, situations and behaviours. European Journal of Personality, 21(6), 789–810. https://doi.org/10.1002/per.640
Parsons, C. E., Crane, C., Parsons, L. J., Fjorback, L. O., & Kuyken, W. (2017). Home practice in mindfulness-based cognitive therapy and mindfulness-based stress reduction: A systematic review and meta-analysis of participants’ mindfulness practice and its association with outcomes. Behaviour Research and Therapy, 95, 29–41. https://doi.org/10.1016/j.brat.2017.05.004
Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., & the R Development Core Team. (2013). nlme: Linear and nonlinear mixed effects models (R package version 3.1–108) [Computer software]. http://www2.uaem.mx/r-mirror/web/packages/nlme/citation.html
Pinto, A. (2009). Mindfulness and psychosis. In F. Didonna (Ed.), Clinical handbook of mindfulness (pp. 339–368). Springer. https://doi.org/10.1007/978-0-387-09593-6_19
Potes, A., Souza, G., Nikolitch, K., Penheiro, R., Moussa, Y., Jarvis, E., Looper, K., & Rej, S. (2018). Mindfulness in severe and persistent mental illness: A systematic review. International Journal of Psychiatry in Clinical Practice, 22(4), 253–261. https://doi.org/10.1080/13651501.2018.1433857
Puolakka, K., & Pitkänen, A. (2019). Effectiveness of psychosocial interventions on quality of life of patients with schizophrenia and related disorders: A systematic review. Archives of Psychiatric Nursing, 33(5), 73–82. https://doi.org/10.1016/j.apnu.2019.07.001
Raphael, J., Price, O., Hartley, S., Haddock, G., Bucci, S., & Berry, K. (2021). Overcoming barriers to implementing ward-based psychosocial interventions in acute inpatient mental health settings: A meta-synthesis. International Journal of Nursing Studies, 115, 103870. https://doi.org/10.1016/j.ijnurstu.2021.103870
Rector, N. A. (2007). Homework use in cognitive therapy for psychosis: A case formulation approach. Cognitive and Behavioral Practice, 14(3), 303–316. https://doi.org/10.1016/j.cbpra.2006.10.008
Rights, J. D., & Sterba, S. K. (2019). Quantifying explained variance in multilevel models: An integrative framework for defining R-squared measures. Psychological Methods, 24(3), 309–338. https://doi.org/10.1037/met0000184
Ritsner, M., Kurs, R., Gibel, A., Ratner, Y., & Endicott, J. (2005). Validity of an abbreviated Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-18) for schizophrenia, schizoaffective, and mood disorder patients. Quality of Life Research, 14(7), 1693–1703. https://doi.org/10.1007/s11136-005-2816-9
Rivera, G., Fuentes-Ferrada, R., Krogh, E., & Langer, Á. I. (2023). Mindfulness and compassion as a path to recovery and personal discovery: A first-episode schizophrenia case study. In J. A. Díaz-Garrido, R. Zúñiga, H. Laffite, & E. Morris (Eds.), Psychological interventions for psychosis (pp. 539–557). Springer. https://doi.org/10.1007/978-3-031-27003-1_25
Rodabaugh, E., & Moeyaert, M. (2017). Multilevel modeling of single-case data: An introduction and tutorial for the applied researcher. NERA Conference Proceedings, 8. https://opencommons.uconn.edu/nera-2017/8
Schennach, R., Obermeier, M. J., Seemüller, F. H., Jäger, M., Schmauss, M., Laux, G., Pfeiffer, H., Naber, D., Schmidt, L. G., Gaebel, W., Klosterkötter, J., Heuser, I., Maier, W., Lemke, M. R., Ruether, E., Klingberg, S., Gastpar, M., Riedel, M., & Möller, H.-J. (2012). Evaluating depressive symptoms in schizophrenia: A psychometric comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale. Psychopathology, 45(5), 276–285. https://doi.org/10.1159/000336729
Shore, D. (2006). Ethical issues in schizophrenia research: A commentary on some current concerns. Schizophrenia Bulletin, 32(1), 26–29. https://doi.org/10.1093/schbul/sbj031
Skivington, K., Matthews, L., Simpson, S. A., Craig, P., Baird, J., Blazeby, J. M., Boyd, K. A., Craig, N., French, D. P., McIntosh, E., Petticrew, M., Rycroft-Malone, J., White, M., & Moore, L. (2021). A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance. BMJ, 374(1), n2061. https://doi.org/10.1136/bmj.n2061
Slade, M., Blackie, L., & Longden, E. (2019). Personal growth in psychosis. World Psychiatry, 18(1), 29–30. https://doi.org/10.1002/wps.20585
Spada, M. M., Mohiyeddini, C., & Wells, A. (2008). Measuring metacognitions associated with emotional distress: Factor structure and predictive validity of the Metacognitions Questionnaire 30. Personality and Individual Differences, 45(3), 238–242. https://doi.org/10.1016/j.paid.2008.04.005
Sun, X., Zhu, C., & So, S. H. W. (2017). Dysfunctional metacognition across psychopathologies: A meta-analytic review. European Psychiatry, 45, 139–153. https://doi.org/10.1016/j.eurpsy.2017.05.029
Van den Noortgate, W., & Onghena, P. (2003). Combining single-case experimental data using hierarchical linear models. School Psychology Quarterly, 18(3), 325–346. https://doi.org/10.1521/scpq.18.3.325.22577
Vergara, R. C., Baquedano, C., Lorca-Ponce, E., Steinebach, C., & Langer, Á. I. (2022). The impact of baseline mindfulness scores on mindfulness-based intervention outcomes: Toward personalized mental health interventions. Frontiers in Psychology, 13, 934614. https://doi.org/10.3389/fpsyg.2022.934614
Wells, A., & Cartwright-Hatton, S. (2004). A short form of the Metacognitions Questionnaire: Properties of the MCQ-30. Behaviour Research and Therapy, 42(4), 385–396. https://doi.org/10.1016/S0005-7967(03)00147-5
Wells, A., & Matthews, G. (1994). Attention and emotion: A clinical perspective. Erlbaum.
Wright, A., Fowler, D., & Greenwood, K. (2020). Influences on functional outcome and subjective recovery in individuals with and without First Episode Psychosis: A metacognitive model. Psychiatry Research, 284, 112643. https://doi.org/10.1016/j.psychres.2019.112643
York, M. (2007). A qualitative study into the experience of individuals involved in a mindfulness group within an acute inpatient mental health unit. Journal of Psychiatric and Mental Health Nursing, 14(6), 603–608. https://doi.org/10.1111/j.1365-2850.2007.01148.x
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All authors contributed to the study conception and design. Recruitment, intervention delivery, and data collection were completed by Joseph Ridler. Material preparation and data analysis were performed primarily by Joseph Ridler, with input from Audrey Millar and Matthias Schwannauer. The first draft of the manuscript was written by Joseph Ridler and all authors commented on previous versions of the manuscript. All authors have read and approved the final manuscript.
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Ridler, J., Millar, A. & Schwannauer, M. Mindfulness-Based Interventions for People Experiencing Psychosis: A Randomized Feasibility Study. Mindfulness (2024). https://doi.org/10.1007/s12671-024-02326-5
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DOI: https://doi.org/10.1007/s12671-024-02326-5